Universidad de La Sabana

About: Universidad de La Sabana is a education organization based out in Chía, Colombia. It is known for research contribution in the topics: Population & Supply chain. The organization has 3236 authors who have published 3676 publications receiving 24490 citations.

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.

Abstract: Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.

Planning cancer control in Latin America and the Caribbean

Abstract: Non-communicable diseases, including cancer, are overtaking infectious disease as the leading health-care threat in middle-income and low-income countries. Latin American and Caribbean countries are struggling to respond to increasing morbidity and death from advanced disease. Health ministries and health-care systems in these countries face many challenges caring for patients with advanced cancer: inadequate funding; inequitable distribution of resources and services; inadequate numbers, training, and distribution of health-care personnel and equipment; lack of adequate care for many populations based on socioeconomic, geographic, ethnic, and other factors; and current systems geared toward the needs of wealthy, urban minorities at a cost to the entire population. This burgeoning cancer problem threatens to cause widespread suffering and economic peril to the countries of Latin America. Prompt and deliberate actions must be taken to avoid this scenario. Increasing efforts towards prevention of cancer and avoidance of advanced, stage IV disease will reduce suffering and mortality and will make overall cancer care more affordable. We hope the findings of our Commission and our recommendations will inspire Latin American stakeholders to redouble their efforts to address this increasing cancer burden and to prevent it from worsening and threatening their societies.

Estrogen Deficiency and the Origin of Obesity during Menopause.

Abstract: Sex hormones strongly influence body fat distribution and adipocyte differentiation. Estrogens and testosterone differentially affect adipocyte physiology, but the importance of estrogens in the development of metabolic diseases during menopause is disputed. Estrogens and estrogen receptors regulate various aspects of glucose and lipid metabolism. Disturbances of this metabolic signal lead to the development of metabolic syndrome and a higher cardiovascular risk in women. The absence of estrogens is a clue factor in the onset of cardiovascular disease during the menopausal period, which is characterized by lipid profile variations and predominant abdominal fat accumulation. However, influence of the absence of these hormones and its relationship to higher obesity in women during menopause are not clear. This systematic review discusses of the role of estrogens and estrogen receptors in adipocyte differentiation, and its control by the central nervous systemn and the possible role of estrogen-like compounds and endocrine disruptors chemicals are discussed. Finally, the interaction between the decrease in estrogen secretion and the prevalence of obesity in menopausal women is examined. We will consider if the absence of estrogens have a significant effect of obesity in menopausal women.

The Roy Adaptation Model

Abstract: Table of Contents Copyright, iv Preface, v Acknowledgments, viii Contributors, ix Reviewers, xii Part One Introduction to the Roy Adaptation Model, 1 Chapter 1 Nursing as a Knowledge-Based Profession, 2 Chapter 2 Elements of the Roy Adaptation Model, 25 Chapter 3 The Nursing Process According to the Roy Adaptation Model, 55 Chapter 4 Overview of Adaptive Modes, 87 Part Two The Adaptive Modes for the Individual, 109 Chapter 5 Oxygenation, 110 Chapter 6 Nutrition, 128 Chapter 7 Elimination, 146 Chapter 8 Activity and Rest, 165 Chapter 9 Protection, 198 Chapter 10 Senses, 222 Chapter 11 Fluid, Electrolyte, and Acid-Base Balance, 254 Chapter 12 Neurologic Function, 269 Chapter 13 Endocrine Function, 302 Chapter 14 Self-Concept Mode of the Person, 321 Chapter 15 Role Function Mode of the Person, 358 Chapter 16 Interdependence Mode of the Person, 384 Part Three Adaptive Modes of Relating Persons, 409 Chapter 17 Physical Mode of Relating People, 411 Chapter 18 Group Identity Mode of Relating Persons, 432 Chapter 19 Role Function Mode of Relating Persons, 457 Chapter 20 Interdependence Mode of Relating Persons, 484 Part Four Applications of the Roy Adaptation Model, 505 Chapter 21 Applications of the Roy Adaptation Model, 507 Index, 535