scispace - formally typeset
Search or ask a question
Institution

Universidade de Pernambuco

EducationRecife, Brazil
About: Universidade de Pernambuco is a education organization based out in Recife, Brazil. It is known for research contribution in the topics: Population & Artificial neural network. The organization has 6147 authors who have published 6948 publications receiving 73648 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: Factors associated with high blood pressure were male gender, obesity, overweight, and lack of physical activity, and knowledge of factors associated with arterial hypertension in adolescents can help support health education campaigns.
Abstract: The aim of this study was to identify the prevalence of systemic arterial hypertension (high blood pressure) and associated health factors in adolescents, using a cross-sectional, population-based, epidemiological design from April to September 2006, within a stratified sample according to school size and shift. Using the Portuguese version of the Global School-Based Student Health Survey questionnaire, 1,878 students from 29 public schools in Greater Metropolitan Recife, Pernambuco State, Brazil, were analyzed for: age, gender, body mass index, fruit, vegetable, alcohol, and tobacco consumption, as well as blood pressure, adopting the 1996 Task Force Report on High Blood Pressure in Children and Adolescents and Centers for Disease Control and Prevention parameters for nutritional status. Prevalence rates for high blood pressure, overweight, and obesity were 17.3%, 6.9%, and 3.7%, respectively. Factors associated with high blood pressure were: male gender, obesity, overweight, and lack of physical activity. Knowledge of factors associated with arterial hypertension in adolescents can help support health education campaigns.

64 citations

Journal ArticleDOI
01 Jul 2015-BMJ Open
TL;DR: The aim is to evaluate the effectiveness of a participatory shared care strategy in improving coordination across care levels and related care quality, in health services networks in six different healthcare systems of Latin America.
Abstract: Introduction Although fragmentation in the provision of healthcare is considered an important obstacle to effective care, there is scant evidence on best practices in care coordination in Latin America. The aim is to evaluate the effectiveness of a participatory shared care strategy in improving coordination across care levels and related care quality, in health services networks in six different healthcare systems of Latin America. Methods and analysis A controlled before and after quasi-experimental study taking a participatory action research approach. In each country, two comparable healthcare networks were selected—intervention and control. The study contains four phases: (1) A baseline study to establish network performance in care coordination and continuity across care levels, using (A) qualitative methods: semi-structured interviews and focus groups with a criterion sample of health managers, professionals and users; and (B) quantitative methods: two questionnaire surveys with samples of 174 primary and secondary care physicians and 392 users with chronic conditions per network. Sample size was calculated to detect a proportion difference of 15% and 10%, before and after intervention (α=0.05; β=0.2 in a two-sided test); (2) a bottom-up participatory design and implementation of shared care strategies involving micro-level care coordination interventions to improve the adequacy of patient referral and information transfer. Strategies are selected through a participatory process by the local steering committee (local policymakers, health care network professionals, managers, users and researchers), supported by appropriate training; (3) Evaluation of the effectiveness of interventions by measuring changes in levels of care coordination and continuity 18 months after implementation, applying the same design as in the baseline study; (4) Cross-country comparative analysis. Ethics and dissemination This study complies with international and national legal stipulations on ethics. Conditions of the study procedure were approved by each country9s ethical committee. A variety of dissemination activities are implemented addressing the main stakeholders. Registration No.257 Clinical Research Register of the Santa Fe Health Department, Argentina.

64 citations

Journal ArticleDOI
TL;DR: The results obtained showed that, among patients undergoing toothbrushing there was a significant reduction in duration of mechanical ventilation, and a tendency to reduce the incidence of VAP and length of ICU stay, although without statistical significance.
Abstract: Nosocomial pneumonia has correlated to dental plaque and to oropharynx colonization in patients receiving mechanical ventilation. The interruption of this process, by preventing colonization of pathogenic bacteria, represents a potential procedure for the prevention of ventilator-associated pneumonia (VAP). The study design was a prospective, randomized trial to verify if oral hygiene through toothbrushing plus chlorhexidine in gel at 0.12% reduces the incidence of ventilatior-associated pneumonia, the duration of mechanical ventilation, the length of hospital stay and the mortality rate in ICUs, when compared to oral hygiene only with chlorhexidine, solution of 0.12%, without toothbrushing, in adult individuals under mechanical ventilation, hospitalized in Clinical/Surgical and Cardiology Intensive Care Units (ICU). The study protocol was approved by the Ethical Committee of Research of the Health Sciences Center of the Federal University of Pernambuco – Certificate of Ethical Committee Approval (CAAE) 04300012500005208. Because it was a randomized trial, the research used CONSORT 2010 checklist criteria. Seven hundred sixteen patients were admitted into the ICU; 219 fulfilled the criteria for inclusion and 213 patients were included; 108 were randomized to control group and 105 to intervention group. Toothbrushing plus 0.12% chlorhexidine gel demonstrated a lower incidence of VAP throughout the follow up period, although the difference was not statistically significant (p = 0.084). There was a significant reduction of the mean time of mechanical ventilation in the toothbrushing group (p = 0.018). Regarding the length of hospital stay in the ICU and mortality rates, the difference was not statistically significant (p = 0.064). The results obtained showed that, among patients undergoing toothbrushing there was a significant reduction in duration of mechanical ventilation, and a tendency to reduce the incidence of VAP and length of ICU stay, although without statistical significance. Retrospectively registered in the Brazilian Clinical Trials Registry (Registro Brasileiro de Ensaios Clinicos) - RBR-4TWH4M (4 September 2016).

64 citations

Journal ArticleDOI
TL;DR: With the objective of establishing guidelines for the prevention, diagnosis and treatment of compensatory hyperhidrosis, consensus meetings were held and the consensus text was posted on the Internet, becoming the object of further corrections and revisions prior to taking on its present form.
Abstract: With the objective of establishing guidelines for the prevention, diagnosis and treatment of compensatory hyperhidrosis, consensus meetings were held. Attendees included a general surgeon and thoracic surgeons affiliated with the Brazilian Society of Thoracic Surgery. The topics addressed were those that would ostensibly broaden multidisciplinary knowledge. Based on recent guidelines for the prevention, diagnosis and (clinical and surgical) treatment of compensatory hyperhidrosis, as well as on a review of the medical literature, the participants prepared a preliminary text, whose recommendations were revised and subsequently approved by all of the participants. The consensus text was posted on the Internet, becoming the object of further corrections and revisions prior to taking on its present form.

64 citations

Journal ArticleDOI
TL;DR: The results suggest that DNA binding can be involved in the biological activity mechanism and may guide the choice of the size and shape of the intercalating part of the ligand and the strategic selection of substituents that increase DNA-binding or antiproliferative properties.
Abstract: In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide derivatives (3a-h) were synthesized, their antiproliferative activities were evaluated, and DNA binding properties were performed with calf thymus DNA (ctDNA) by electronic absorption and fluorescence spectroscopies. Both hyperchromic and hypochromic effects, as well as red or blue shifts were demonstrated by addition of ctDNA to the derivatives. The calculated binding constants ranged from 1.74 × 10(4) to 1.0 × 10(6) M(-1) and quenching constants from -0.2 × 10(4) to 2.18 × 10(4) M(-1) indicating high affinity to ctDNA base pairs. The most efficient compound in binding to ctDNA in vitro was (Z)-2-(acridin-9-ylmethylene)-N- (4-chlorophenyl) hydrazinecarbothioamide (3f), while the most active compound in antiproliferative assay was (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide (3a). There was no correlation between DNA-binding and in vitro antiproliferative activity, but the results suggest that DNA binding can be involved in the biological activity mechanism. This study may guide the choice of the size and shape of the intercalating part of the ligand and the strategic selection of substituents that increase DNA-binding or antiproliferative properties.

64 citations


Network Information
Related Institutions (5)
University of São Paulo
272.3K papers, 5.1M citations

91% related

Universidade Federal de Minas Gerais
75.6K papers, 1.2M citations

90% related

Federal University of São Paulo
49.3K papers, 935.5K citations

90% related

Federal University of Rio de Janeiro
89.1K papers, 1.5M citations

90% related

Universidade Federal de Santa Catarina
55.4K papers, 714.4K citations

90% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202314
202261
2021840
2020823
2019571
2018547