Universidade Estadual de Londrina

About: Universidade Estadual de Londrina is a education organization based out in Londrina, Brazil. It is known for research contribution in the topics: Population & Toxoplasma gondii. The organization has 13052 authors who have published 19291 publications receiving 212123 citations.

Mutagenic effects of tributyltin and inorganic lead (Pb II) on the fish H. malabaricus as evaluated using the comet assay and the piscine micronucleus and chromosome aberration tests

Abstract: Genotoxicity studies on toxic metals and their organic compounds are very important, especially so in the investigation of the effects of these compounds on the aquatic environments where they tend to accumulate. The use of endemic aquatic organisms as biological sentinels has proved useful to environmental monitoring. We assessed the mutagenic potential of tributyltin (TBT) and inorganic lead (PbII) using samples of the fish Hoplias malabaricus (commonly called traira) using the comet assay and the piscine micronucleus and chromosome aberration tests. Eighteen H. malabaricus were acclimatized in three individual aquariums, each containing six fish, six fish being exposed to 0.3 mg/g of body weight (bw) of TBT, six to 21 mg/g bw of PbII and six being used as controls. Exposure to TBT and PbII was achieved by feeding the fish every five days with Astyanax (a small fish that is part of the normal diet of H. malabaricus) which had been injected with solutions of TBT, PbII or with water (the control group). After two months the H. malabaricus were sacrificed and their peripheral blood collected and subjected to the comet and micronucleus assays, the chromosome aberration assay being conducted using kidney-tissue. Although the comet assay showed now mutagenic effects at the lead concentrations used but encountered results with TBT, the micronucleus and chromosome aberrations assays both indicated that TBT and PbII are potentially mutagenic (p < 0.01), the micronucleus assay showing morphological alterations of the nucleus.

Diretriz Brasileira de Insuficiência Cardíaca Crônica e Aguda.

Abstract: Parte 1: Diretriz Brasileira de Insuficiencia Cardiaca Cronica […] Diretriz Brasileira de Insuficiencia Cardiaca Cronica e Aguda

II Consenso Brasileiro em Doença de Chagas, 2015

Abstract: RESUMO A doenca de Chagas e uma condicao cronica negligenciada com elevada carga de morbimortalidade e impacto dos pontos de vista psicologico, social e economico. Representa um importante problema de saude publica no Brasil, com diferentes cenarios regionais. Este documento traduz a sistematizacao das evidencias que compoe o Consenso Brasileiro de Doenca de Chagas. O objetivo foi sistematizar estrategias de diagnostico, tratamento, prevencao e controle da doenca de Chagas no pais, de modo a refletir as evidencias cientificas disponiveis. Sua construcao fundamentou-se na articulacao e contribuicao estrategica de especialistas brasileiros com conhecimento, experiencia e atualizacao sobre diferentes aspectos da doenca. Representa o resultado da estreita colaboracao entre a Sociedade Brasileira de Medicina Tropical e o Ministerio da Saude. Espera-se com este documento fortalecer o desenvolvimento de acoes integradas para enfrentamento da doenca no pais com foco em epidemiologia, gestao, atencao integral (incluindo familias e comunidades), comunicacao, informacao, educacao e pesquisas.