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Universidade Estadual de Londrina

EducationLondrina, Brazil
About: Universidade Estadual de Londrina is a education organization based out in Londrina, Brazil. It is known for research contribution in the topics: Population & Toxoplasma gondii. The organization has 13052 authors who have published 19291 publications receiving 212123 citations.


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Journal ArticleDOI
TL;DR: Este trabalho demonstra a extrema importância da presenca dos tributarios para a manutencao da diversidade das especies em um reservatorio, em funcao da preservacao das caracteristicas originais do sistema lotico naqueles trechos e consequente reducao do impacto do represamento.
Abstract: As especies foram coletadas em quatro trechos ao longo de um gradiente formado pelo reservatorio UHE Escola Engenharia Mackenzie (Capivara). A diversidade de especies foi analisada pela constância, indice de Shannon-Wiener e similaridade da composicao entre trechos atraves do coeficiente de Jaccard. O reservatorio tem uma riqueza de peixes composta por 67 especies incluidas em 5 ordens; 47% das especies sao constantes, 15 % sao acessorias e 28% sao acidentais. Os maiores indices de diversidade de Shannon-Wiener e similaridade de Jaccard foram obtidos em Cinzas e Tibagi, que sao os trechos mais distantes da barragem e que apresentam grandes tributarios. Os menores indices foram encontrados em Cruzalia e Porecatu, os quais correspondem aos trechos com caracteristicas, respectivamente, de ambientes lotico e semi-lotico. Este trabalho demonstra a extrema importância da presenca dos tributarios para a manutencao da diversidade das especies em um reservatorio, em funcao da preservacao das caracteristicas originais do sistema lotico naqueles trechos e consequente reducao do impacto do represamento.

57 citations

Journal ArticleDOI
TL;DR: Two novel anomaly detection mechanisms based on statistical procedure Principal Component Analysis and the Ant Colony Optimization metaheuristic are presented and compared, demonstrating that the systems are able to enhance the detection of anomalous behavior by maintaining a satisfactory false-alarm rate.

57 citations

Journal ArticleDOI
TL;DR: This editorial discusses recent evidence from the research group on the analgesic and antiinflammatory mechanisms of the flavonoid naringenin (4’,5,7-tryhidroxy-flavanone).
Abstract: In this editorial, we discuss recent evidence from our research group on the analgesic and antiinflammatory mechanisms of the flavonoid naringenin (4’,5,7-tryhidroxy-flavanone). Flavonoids are polyphenolic compounds found in human diet [1]. Naringenin belongs to flavanone class of flavonoids, and it is mainly found in citrus fruits including, lemon, orange, tangerine and grapefruit [1-5]. The antioxidant activity is the most recognized effect of flavonoids, which depends, for instance, on hydrogen donation and electron stabilization in the phenolic rings [1]. Naringenin presents therapeutic effect in several models of inflammatory pain [2, 3, 5]. Naringenin inhibits the pain-like behavior induced by inflammatory stimuli such as phenyl-p-benzoquinone, acetic acid, formalin, complete Freund ́s adjuvant, capsaicin, carrageenan [2], superoxide anion [3], and LPS [5]. Moreover, naringenin inhibits UVB irradiation-induced skin inflammatory edema, cytokine production, myeloperoxidase activity, matrix metalloproteinase-9 activity, and oxidative stress [4]. Pathogen (PAMPs) and damage (DAMPs) associated molecular patterns and inflammatory mediators activate resident macrophages. Resident macrophages produce chemotactic molecules to recruit leukocytes to the inflammatory foci, mainly neutrophils in the early events of inflammation. Activated macrophages and neutrophils induce oxidative stress by producing superoxide anion and other reactive oxygen (ROS) and nitrogen species. Naringenin inhibits leukocyte recruitment [2-5] and production of superoxide anion [3-5], whilst increases GSH [2-4], and antioxidant capacity [3-5]. Naringenin also acts on macrophages inducing Nrf2 activation, a nuclear factor that induces antioxidant and anti-inflammatory responses, inducing HO-1 expression [3]. PAMPs, DAMPs and ROS induce NFκB activation in macrophages resulting in the production of pro-hyperalgesic cytokine such as IL-33, TNFα, IL-1β and IL-6. Pro-hyperalgesic cytokines induce the production of lipid mediators such as PGE2 that sensitize the nociceptor neurons. Naringenin inhibits LPSand carrageenan-induced NFκB activation in vivo [2] and in vitro [5], which contributes to naringenin inhibition of IL-33 [2], TNFα [3-5], IL-1β [2, 4, 5] and IL-6 [4,5] production and expression of cyclooxygenase-2 mRNA [3] (Figure 1).

57 citations

Journal ArticleDOI
TL;DR: The results suggested that PCA has a high potential in the control of B. cinerea and inhibition of EPS (important virulence factor) and this natural compound is a potential alternative to postharvest control of gray mold disease.
Abstract: One of the most important postharvest plant pathogens that affect strawberries, grapes and tomatoes is Botrytis cinerea, known as gray mold. The fungus remains in latent form until spore germination conditions are good, making infection control difficult, causing great losses in the whole production chain. This study aimed to purify and identify phenazine-1-carboxylic acid (PCA) produced by the Pseudomonas aeruginosa LV strain and to determine its antifungal activity against B. cinerea. The compounds produced were extracted with dichloromethane and passed through a chromatographic process. The purity level of PCA was determined by reversed-phase high-performance liquid chromatography semi-preparative. The structure of PCA was confirmed by nuclear magnetic resonance and electrospray ionization mass spectrometry. Antifungal activity was determined by the dry paper disc and minimum inhibitory concentration (MIC) methods and identified by scanning electron microscopy and confocal microscopy. The results showed that PCA inhibited mycelial growth, where MIC was 25 µg mL-1. Microscopic analysis revealed a reduction in exopolysaccharide (EPS) formation, showing distorted and damaged hyphae of B. cinerea. The results suggested that PCA has a high potential in the control of B. cinerea and inhibition of EPS (important virulence factor). This natural compound is a potential alternative to postharvest control of gray mold disease.

56 citations

Journal ArticleDOI
TL;DR: The prevalence of neck and low back pain was higher in older adolescents and physical inactivity in the sporting context and occupational activities could be a risk factor to increase the chances of back pain.
Abstract: Purpose Back pain affects people of all ages This may be associated with physical inactivity, and in the case of physical activity in different domains, the relationship with back pain is not clear in the literature The aim of this study was to estimate the prevalence of low back and neck pain and investigate their association in different domains of physical inactivity Methods 1011 randomly selected students participated in this study Neck and back pain were assessed using the Nordic questionnaire, whereas the Baecke Physical Activity questionnaire was used to measure physical activity domains Separate Binary Logistic Regression models were performed to investigate the association of physical activity domains with neck or back pain Results 174% of the students reported cervical pain, while 180% reported low back pain Older adolescents had a higher prevalence of cervical pain (244%) than younger adolescents (119%) (p value Conclusions The prevalence of neck and low back pain was higher in older adolescents and physical inactivity in the sporting context and occupational activities could be a risk factor to increase the chances of back pain

56 citations


Authors

Showing all 13138 results

NameH-indexPapersCitations
Michael Maes11580752050
Fernando Q. Cunha8868231501
Mariangela Hungria6738915219
Petar Popovski5975621009
Waldiceu A. Verri5424910311
Thiago M. Cunha542689519
Emerson Franchini524029620
Celso Vataru Nakamura5141810908
Diego Augusto Santos Silva5138953077
Susan M. Tarlo5026310850
Paulo Caramelli453669666
Fabio Pitta4421311925
Joaquim Gama-Rodrigues432258380
Ricardo Almeida432507304
Hamilton Roschel432355894
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202324
2022151
20211,220
20201,433
20191,333
20181,308