Institution
Universidade Estadual de Londrina
Education•Londrina, Brazil•
About: Universidade Estadual de Londrina is a education organization based out in Londrina, Brazil. It is known for research contribution in the topics: Population & Toxoplasma gondii. The organization has 13052 authors who have published 19291 publications receiving 212123 citations.
Topics: Population, Toxoplasma gondii, Oxidative stress, Starch, Germination
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors developed biodegradable trays from cassava starch, sugarcane fibers and Na-montmorillonite (Na-MMT) using a baking process and to study the effects of these components on the microstructure and physicochemical and mechanical properties of the trays.
84 citations
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TL;DR: The results demonstrated that botryosphaeran exhibited effective antioxidants activity as supported by many different assays, suggesting that this β-D-glucan may serve as a source of a new bioactive compound with effective antioxidant activity.
84 citations
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TL;DR: The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus, construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels.
Abstract: Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles
84 citations
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TL;DR: The results suggest that LPS-induced inflammatory pain in mice is solely dependent on the TLR4/MyD88 rather than the TLr4/TRIF signaling pathway, which triggers pronociceptive cytokine TNF-α release that in turn mediates rises in KC/CXCL1 and IL-1β expression.
Abstract: Inflammatory pain can be triggered by different stimuli, such as trauma, radiation, antigen and infection. In a model of inflammatory pain caused by infection, injection in the mice paw of lipopolysaccharide (LPS), a Toll-like receptor 4 (TLR4) agonist, produces mechanical hyperalgesia. We identify here the TLR4 linked signaling pathways that elicit this response. Firstly, LPS paw injection in wild type (WT) mice produced mechanical hyperalgesia that was not altered in TRIF-/- mice. On the other hand, this response was absent in TLR4 mutant and MyD88 null mice and reduced in TNFR1 null mice. Either an IL-1 receptor antagonist, anti-KC/CXCL1 antibody, indomethacin or guanethidine injection also lessened this response. Moreover, LPS-induced time dependent increases in TNF-α, KC/CXCL1 and IL-1β expression in the mice paw, which were absent in TLR4 mutant and MyD88 null mice. Furthermore, in TNFR1 deficient mice, the LPS-induced rises in KC/CXCL1 and IL-1β release were less than in their wild type counterpart. LPS also induced increase of myeloperoxidase activity in the paw skin, which was inhibited in TLR4 mutant and MyD88 null mice, and not altered in TRIF-/- mice. These results suggest that LPS-induced inflammatory pain in mice is solely dependent on the TLR4/MyD88 rather than the TLR4/TRIF signaling pathway. This pathway triggers pronociceptive cytokine TNF-α release that in turn mediates rises in KC/CXCL1 and IL-1β expression. Finally, these cytokines might be involved in stimulating production of directly-acting hyperalgesic mediators such as prostaglandins and sympathomimetic amine.
84 citations
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TL;DR: The presence of cyanogenic glycosides was determined in 70 plant species from the campus of the State University of Londrina, PR, Brazil, and a further 45 plantspecies from the Forestry Reserve on the Doralice Farm in Ibipora, Brazil.
Abstract: The presence of cyanogenic glycosides was determined in 70 plant species from the campus of the State University of Londrina, PR, Brazil, and a further 45 plant species from the Forestry Reserve on the Doralice Farm in Ibipora, PR, Brazil. Of the vegetative species from the State University of Londrina, 7.1% showed cyanogenic glycosides: Manihot esculenta (Euphorbiaceae), Passiflora edulis (Passifloraceae), Macadamia ternifolia (Proteaceae), Prunus persica (Rosaceae) and Beloperone sp (Acanthaceae).The first four species were considered to be potentially cyanogenic in the field. From the Forestry Reserve on the Doralice Farm, the plant species with cyanogenic glycosides were: Holocalix balanseae (Caesalpinaceae), Nectranda megapotamica (Lauraceae), Trichilia casareti (Meliaceae), Trichilia elegans (Meliaceae) and Rapanea umbellata (Myrsinaceae), making 11.1% of the total species analyzed. Only Holocalix balanseae was considered to be potentially cyanogenic in the field.
84 citations
Authors
Showing all 13138 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Maes | 115 | 807 | 52050 |
Fernando Q. Cunha | 88 | 682 | 31501 |
Mariangela Hungria | 67 | 389 | 15219 |
Petar Popovski | 59 | 756 | 21009 |
Waldiceu A. Verri | 54 | 249 | 10311 |
Thiago M. Cunha | 54 | 268 | 9519 |
Emerson Franchini | 52 | 402 | 9620 |
Celso Vataru Nakamura | 51 | 418 | 10908 |
Diego Augusto Santos Silva | 51 | 389 | 53077 |
Susan M. Tarlo | 50 | 263 | 10850 |
Paulo Caramelli | 45 | 366 | 9666 |
Fabio Pitta | 44 | 213 | 11925 |
Joaquim Gama-Rodrigues | 43 | 225 | 8380 |
Ricardo Almeida | 43 | 250 | 7304 |
Hamilton Roschel | 43 | 235 | 5894 |