Institution
Universidade Estadual do Vale do Acaraú
Education•Sobral, Brazil•
About: Universidade Estadual do Vale do Acaraú is a education organization based out in Sobral, Brazil. It is known for research contribution in the topics: Chalcone & Health promotion. The organization has 205 authors who have published 234 publications receiving 1901 citations.
Papers published on a yearly basis
Papers
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12 citations
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TL;DR: 1,8-cineole has a dual effect on tracheal smooth muscle contraction resulting in a biphasic effect, which is suggested to be mediated by activation of TRPM8 channels and the relaxation effect is mediated by the blockage of L-type VGCC.
Abstract: 1,8-Cineole is a cyclic monoterpenoid used in folk medicine for treatment of numerous respiratory diseases and other infections. 1,8-Cineole has anti-inflammatory, antioxidant, and myorelaxant effects, as well as low toxicity. In the present study, the effects of 1,8-cineole on contractility and voltage-gated calcium channels (VGCC) in tracheal smooth muscle were investigated. Intact and dissociated tracheal smooth muscle were used for muscle contraction and patch-clamp recordings, respectively. In experiments involving muscle contraction, 1,8-cineole potentiated contractions at low concentrations and relaxed contractions induced by isotonic K+ at high concentrations. AMTB (a TRPM8 channel blocker) reduced the potentiation induced by 1,8-cineole while indomethacin (a COX inhibitor) did not block this effect. In dissociated myocytes, 1,8-cineole partially blocked Ba2+ currents through VGCC in a concentration-dependent manner. 1,8-Cineole shifted the steady-state activation and inactivation curves to the left and also reduced the current decay time constant. In conclusion, 1,8-cineole has a dual effect on tracheal smooth muscle contraction resulting in a biphasic effect. Our data suggest that the potentiation effect is mediated by activation of TRPM8 channels and the relaxation effect is mediated by the blockage of L-type VGCC.
12 citations
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TL;DR: The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential with significant activity towards P. aeruginosa and S. aureus 358.
Abstract: The n-hexane extract of the stem bark of Croton anisodontus yielded 2-hydroxy-3,4,6-trimethoxyacetophenone, a well-known substance, but isolated from this species for the first time. The antimicrobial and modulatory activities of the compound towards Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans, C. krusei and C. tropicalis strains were assessed. Antibiotics such as amikacin, gentamicin and neomycin were used in a sub-inhibitory concentration. Significant activity was observed towards P. aeruginosa and S. aureus 358, with p < 0.001 in association with amikacin. The present results place C anisodontus as an alternative source of 2-hydroxy-3,4,6-trimethoxyacetophenone with antibacterial potential.
12 citations
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TL;DR: In this paper, the authors evaluated the interactions of 4'-acetamidechalcones with enzymatic and structural targets of SARS-CoV-2 and with the host's ACE2, which is recognized by the virus, facilitating its entry into cells.
12 citations
Authors
Showing all 212 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tigressa Helena Soares Rodrigues | 17 | 57 | 874 |
Cláudia F. Santos | 16 | 40 | 756 |
Francisco H. A. Rodrigues | 16 | 27 | 1393 |
Hélcio Silva dos Santos | 15 | 112 | 832 |
Paulo Nogueira Bandeira | 15 | 93 | 947 |
Raquel Oliveira dos Santos Fontenelle | 14 | 46 | 744 |
Francisco Rosemiro Guimarães Ximenes Neto | 13 | 61 | 533 |
Maria Rose Jane R. Albuquerque | 13 | 43 | 612 |
Rodrigo Maranguape Silva da Cunha | 12 | 32 | 448 |
Cibelly Aliny Siqueira Lima Freitas | 11 | 51 | 327 |
Maria Socorro de Araújo Dias | 11 | 65 | 494 |
Elnatan Bezerra de Souza | 11 | 46 | 359 |
Francisco Ernani Alves Magalhães | 11 | 45 | 298 |
Marcos Cláudio Pinheiro Rogério | 10 | 86 | 383 |
M.G. da Silva | 10 | 28 | 352 |