Universidade Estadual do Vale do Acaraú

About: Universidade Estadual do Vale do Acaraú is a education organization based out in Sobral, Brazil. It is known for research contribution in the topics: Chalcone & Health promotion. The organization has 205 authors who have published 234 publications receiving 1901 citations.

A novel autosomal recessive GJA1 missense mutation linked to Craniometaphyseal dysplasia.

Abstract: Craniometaphyseal dysplasia (CMD) is a rare sclerosing skeletal disorder with progressive hyperostosis of craniofacial bones. CMD can be inherited in an autosomal dominant (AD) trait or occur after de novo mutations in the pyrophosphate transporter ANKH. Although the autosomal recessive (AR) form of CMD had been mapped to 6q21-22 the mutation has been elusive. In this study, we performed whole-exome sequencing for one subject with AR CMD and identified a novel missense mutation (c.716G>A, p.Arg239Gln) in the C-terminus of the gap junction protein alpha-1 (GJA1) coding for connexin 43 (Cx43). We confirmed this mutation in 6 individuals from 3 additional families. The homozygous mutation cosegregated only with affected family members. Connexin 43 is a major component of gap junctions in osteoblasts, osteocytes, osteoclasts and chondrocytes. Gap junctions are responsible for the diffusion of low molecular weight molecules between cells. Mutations in Cx43 cause several dominant and recessive disorders involving developmental abnormalities of bone such as dominant and recessive oculodentodigital dysplasia (ODDD; MIM #164200, 257850) and isolated syndactyly type III (MIM #186100), the characteristic digital anomaly in ODDD. However, characteristic ocular and dental features of ODDD as well as syndactyly are absent in patients with the recessive Arg239Gln Cx43 mutation. Bone remodeling mechanisms disrupted by this novel Cx43 mutation remain to be elucidated.

The Management of Work and Education in Brazil's Unified Health System: thirty years of progress and challenges.

Abstract: Resumo Este artigo faz uma analise historica da Gestao do Trabalho e Educacao na Saude, nas tres decadas do SUS, a partir do referencial da sociologia das profissoes, abordando temas como: o mercado de trabalho, a evolucao dos empregos de saude, a forca de trabalho em saude, a regulacao e a dinâmica das graduacoes em saude. Analisa os momentos que caracterizam a area, desde o pre-SUS ate os dias atuais. O periodo evidencia um “boom” de escolas de saude, com participacao majoritaria do ensino privado; aumento da escolarizacao, iniquidade regional; surgimento perigoso da educacao a distância no campo da saude; desequilibrio entre oferta e demanda de mao de obra; expansao da capacidade instalada; municipalizacao dos empregos de saude; crescimento da equipe multiprofissional; precarizacao do trabalho; crescimento da informalidade dos vinculos empregaticios e deterioracao salarial.

Competências gerenciais de enfermeiras: um novo velho desafio?

Abstract: Artigo de reflexao sobre a atuacao do enfermeiro como gerente da assistencia de enfermagem no atual mundo globalizado e com enormes demandas. Discute a relevância do preparo deste profissional para exercer seu papel no contexto de competencias gerenciais, hoje amplamente difundidas como modelo de gestao. Destaca a importância do desenvolvimento de competencias gerenciais nos enfermeiros desde a formacao na graduacao e de forma continua nos servicos.

Acesso e utilização dos serviços na Estratégia Saúde da Família na perspectiva dos gestores, profissionais e usuários

Abstract: Questionnaires adapted to the Brazilian reality (Primary Care Assessment Tool) to evaluate access to and use of services were distributed to 30 managers, 80 professionals and a random sample of 882 Family Health Strategy (FHS) users in Sao Luis in the state of Maranhao. The differences between the evaluations of managers, professionals and users were identified by the Kruskal-Wallis test and Dunn's post test. Users faced difficulties in access to and use of the services, which were also considered unsatisfactory by managers and professionals. Access was the dimension with the worst evaluation, and non-functioning of units after 6 p.m. and at weekends were the main difficulties. The evaluations of the managers and professionals were almost always divergent from those of the users, with the evaluation of the managers being more favorable. The fact that the service was free of charge, the use of preventive services and the FHS services before the specialized care were well evaluated. The operation of units should attend users' needs, especially that of the working population. Strengthening social participation in local management of the FHS may assist in identifying these needs, thereby reducing the divergent opinions of the players involved.