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Universidade Federal de Mato Grosso

EducationCuiabá, Brazil
About: Universidade Federal de Mato Grosso is a education organization based out in Cuiabá, Brazil. It is known for research contribution in the topics: Population & Species richness. The organization has 7748 authors who have published 10181 publications receiving 89994 citations.


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Journal ArticleDOI
24 Apr 2020
TL;DR: The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir.
Abstract: Importance There is no specific antiviral therapy recommended for coronavirus disease 2019 (COVID-19). In vitro studies indicate that the antiviral effect of chloroquine diphosphate (CQ) requires a high concentration of the drug. Objective To evaluate the safety and efficacy of 2 CQ dosages in patients with severe COVID-19. Design, Setting, and Participants This parallel, double-masked, randomized, phase IIb clinical trial with 81 adult patients who were hospitalized with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was conducted from March 23 to April 5, 2020, at a tertiary care facility in Manaus, Brazilian Amazon. Interventions Patients were allocated to receive high-dosage CQ (ie, 600 mg CQ twice daily for 10 days) or low-dosage CQ (ie, 450 mg twice daily on day 1 and once daily for 4 days). Main Outcomes and Measures Primary outcome was reduction in lethality by at least 50% in the high-dosage group compared with the low-dosage group. Data presented here refer primarily to safety and lethality outcomes during treatment on day 13. Secondary end points included participant clinical status, laboratory examinations, and electrocardiogram results. Outcomes will be presented to day 28. Viral respiratory secretion RNA detection was performed on days 0 and 4. Results Out of a predefined sample size of 440 patients, 81 were enrolled (41 [50.6%] to high-dosage group and 40 [49.4%] to low-dosage group). Enrolled patients had a mean (SD) age of 51.1 (13.9) years, and most (60 [75.3%]) were men. Older age (mean [SD] age, 54.7 [13.7] years vs 47.4 [13.3] years) and more heart disease (5 of 28 [17.9%] vs 0) were seen in the high-dose group. Viral RNA was detected in 31 of 40 (77.5%) and 31 of 41 (75.6%) patients in the low-dosage and high-dosage groups, respectively. Lethality until day 13 was 39.0% in the high-dosage group (16 of 41) and 15.0% in the low-dosage group (6 of 40). The high-dosage group presented more instance of QTc interval greater than 500 milliseconds (7 of 37 [18.9%]) compared with the low-dosage group (4 of 36 [11.1%]). Respiratory secretion at day 4 was negative in only 6 of 27 patients (22.2%). Conclusions and Relevance The preliminary findings of this study suggest that the higher CQ dosage should not be recommended for critically ill patients with COVID-19 because of its potential safety hazards, especially when taken concurrently with azithromycin and oseltamivir. These findings cannot be extrapolated to patients with nonsevere COVID-19. Trial Registration ClinicalTrials.gov Identifier:NCT04323527

852 citations

Journal ArticleDOI
07 Jul 2016-Nature
TL;DR: In this article, the authors used a large data set of plants, birds and dung beetles (1,538, 460 and 156 species, respectively) sampled in 36 catchments in the Brazilian state of Para.
Abstract: Concerted political attention has focused on reducing deforestation, and this remains the cornerstone of most biodiversity conservation strategies. However, maintaining forest cover may not reduce anthropogenic forest disturbances, which are rarely considered in conservation programmes. These disturbances occur both within forests, including selective logging and wildfires, and at the landscape level, through edge, area and isolation effects. Until now, the combined effect of anthropogenic disturbance on the conservation value of remnant primary forests has remained unknown, making it impossible to assess the relative importance of forest disturbance and forest loss. Here we address these knowledge gaps using a large data set of plants, birds and dung beetles (1,538, 460 and 156 species, respectively) sampled in 36 catchments in the Brazilian state of Para. Catchments retaining more than 69–80% forest cover lost more conservation value from disturbance than from forest loss. For example, a 20% loss of primary forest, the maximum level of deforestation allowed on Amazonian properties under Brazil’s Forest Code, resulted in a 39–54% loss of conservation value: 96–171% more than expected without considering disturbance effects. We extrapolated the disturbance-mediated loss of conservation value throughout Para, which covers 25% of the Brazilian Amazon. Although disturbed forests retained considerable conservation value compared with deforested areas, the toll of disturbance outside Para’s strictly protected areas is equivalent to the loss of 92,000–139,000 km2 of primary forest. Even this lowest estimate is greater than the area deforested across the entire Brazilian Amazon between 2006 and 2015 (ref. 10). Species distribution models showed that both landscape and within-forest disturbances contributed to biodiversity loss, with the greatest negative effects on species of high conservation and functional value. These results demonstrate an urgent need for policy interventions that go beyond the maintenance of forest cover to safeguard the hyper-diversity of tropical forest ecosystems.

698 citations

Journal ArticleDOI
TL;DR: In this paper, a Time-Temperature Indicator (TTI) based on a PVA/Chitosan polymeric doped with anthocyanins was used to detect changes in the pH of packaged food products when subjected to improper storage temperatures.

556 citations

Journal ArticleDOI
TL;DR: In this paper, the authors analyzed the current ecological situation and the use of the wetlands in major regions of the world in the context of global climate change and provided a synthesis of the findings and recommendations for sustainable use and protection of these important ecosystems.
Abstract: Wetlands cover at least 6 % of the Earth’s surface. They play a key role in hydrological and biogeochemical cycles, harbour a large part of the world’s biodiversity, and provide multiple services to humankind. However, pressure in the form of land reclamation, intense resource exploitation, changes in hydrology, and pollution threaten wetlands on all continents. Depending on the region, 30–90 % of the world’s wetlands have already been destroyed or strongly modified in many countries with no sign of abatement. Climate change scenarios predict additional stresses on wetlands, mainly because of changes in hydrology, temperature increases, and a rise in sea level. Yet, intact wetlands play a key role as buffers in the hydrological cycle and as sinks for organic carbon, counteracting the effects of the increase in atmospheric CO2. Eight chapters comprising this volume of Aquatic Sciences analyze the current ecological situation and the use of the wetlands in major regions of the world in the context of global climate change. This final chapter provides a synthesis of the findings and recommendations for the sustainable use and protection of these important ecosystems.

509 citations

01 Jan 2013
TL;DR: Acompanhamento supervisionado na identificacao de necessidade dos dados a serem levantados (1*2) Auxiliar no gerenciamento de banco de dados (1*) as discussed by the authors.
Abstract: ________________________________________________________________________________ ______________________________ Atividades de Estagio ________________________________________________________________________________ ______________________________ (1*2) Acompanhar os treinamentos aos usuarios (1*3) Auxiliar no gerenciamento de banco de dados (1*9) Auxiliar no suporte tecnico ao usuario (1*10) Acompanhamento supervisionado na identificacao de necessidade dos dados a serem levantados (1*11) Acompanhamento supervisionado na orientacao de clientes ou usuarios em programas de treinamentos (1*12) Fornecer suporte a usuario/ clientes sobre a utilizacao dos softwares (1*13) Fornecer suporte a usuarios (1*14) Acompanhamento de acoes desenvolvidas pelos analistas de sistemas (1*15) Acompanhamento de instalacoes de redes, micros e comunicacao de dados (1*16) Acompanhamento supervisionado na execucao de testes de qualidade (1*17) Acompanhamento supervisionado na geracao de graficos e relatorios (1*18) Acompanhamento supervisionado na manuntencao de sistemas perifericos (1*19) Acompanhamento supervisionado na tabulacao e analise de dados (1*20) Acompanhamento supervisionado na utilizacao da ferramenta de gerenciamento de clientes (1*21) Acompanhamento supervisionado no desenvolvimento de planilhas eletronicas

506 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202314
2022100
20211,004
20201,069
2019963
2018959