Showing papers by "Universidade Federal de Minas Gerais published in 2010"

Perspectives on Carbon Nanotubes and Graphene Raman Spectroscopy

Abstract: Raman spectroscopy is here shown to provide a powerful tool to differentiate between two different sp2 carbon nanostructures (carbon nanotubes and graphene) which have many properties in common and others that differ. Emphasis is given to the richness of both carbon nanostructures as prototype examples of nanostructured materials. A glimpse toward future developments in this field is presented.

The Impact of Conservation on the Status of the World’s Vertebrates

Abstract: Using data for 25,780 species categorized on the International Union for Conservation of Nature Red List, we present an assessment of the status of the world's vertebrates. One-fifth of species are classified as Threatened, and we show that this figure is increasing: On average, 52 species of mammals, birds, and amphibians move one category closer to extinction each year. However, this overall pattern conceals the impact of conservation successes, and we show that the rate of deterioration would have been at least one-fifth again as much in the absence of these. Nonetheless, current conservation efforts remain insufficient to offset the main drivers of biodiversity loss in these groups: agricultural expansion, logging, overexploitation, and invasive alien species.

Detecting Spammers on Twitter

Abstract: With millions of users tweeting around the world, real time search systems and dierent types of mining tools are emerging to allow people tracking the repercussion of events and news on Twitter. However, although appealing as mechanisms to ease the spread of news and allow users to discuss events and post their status, these services open opportunities for new forms of spam. Trending topics, the most talked about items on Twitter at a given point in time, have been seen as an opportunity to generate trac and revenue. Spammers post tweets containing typical words of a trending topic and URLs, usually obfuscated by URL shorteners, that lead users to completely unrelated websites. This kind of spam can contribute to de-value real time search services unless mechanisms to fight and stop spammers can be found. In this paper we consider the problem of detecting spammers on Twitter. We first collected a large dataset of Twitter that includes more than 54 million users, 1.9 billion links, and almost 1.8 billion tweets. Using tweets related to three famous trending topics from 2009, we construct a large labeled collection of users, manually classified into spammers and non-spammers. We then identify a number of characteristics related to tweet content and user social behavior, which could potentially be used to detect spammers. We used these characteristics as attributes of machine learning process for classifying users as either spammers or nonspammers. Our strategy succeeds at detecting much of the spammers while only a small percentage of non-spammers are misclassified. Approximately 70% of spammers and 96% of non-spammers were correctly classified. Our results also highlight the most important attributes for spam detection on Twitter.

Evolution of the Raman spectra from single-, few-, and many-layer graphene with increasing disorder

Abstract: We report on the micro-Raman spectroscopy of monolayer, bilayer, trilayer, and many layers of graphene (graphite) bombarded by low-energy argon ions with different doses. The evolution of peak frequencies, intensities, linewidths, and areas of the main Raman bands of graphene is analyzed as function of the distance between defects and number of layers. We describe the disorder-induced frequency shifts and the increase in the linewidth of the Raman bands by means of a spatial-correlation model. Also, the evolution of the relative areas ${A}_{D}/{A}_{G}$, ${A}_{{D}^{\ensuremath{'}}}/{A}_{G}$, and ${A}_{{G}^{\ensuremath{'}}}/{A}_{G}$ is described by a phenomenological model. The present results can be used to fully characterize disorder in graphene systems.

Defect characterization in graphene and carbon nanotubes using Raman spectroscopy.

Abstract: This review discusses advances that have been made in the study of defect-induced double-resonance processes in nanographite, graphene and carbon nanotubes, mostly coming from combining Raman spectroscopic experiments with microscopy studies and from the development of new theoretical models The disorder-induced peak frequencies and intensities are discussed, with particular emphasis given to how the disorder-induced features evolve with increasing amounts of disorder We address here two systems, ion-bombarded graphene and nanographite, where disorder is represented by point defects and boundaries, respectively Raman spectroscopy is used to study the ‘atomic structure’ of the defect, making it possible, for example, to distinguish between zigzag and armchair edges, based on selection rules of phonon scattering Finally, a different concept is discussed, involving the effect that defects have on the lineshape of Raman-allowed peaks, owing to local electron and phonon energy renormalization Such effects can be observed by near-field optical measurements on the G ′ feature for doped single-walled carbon nanotubes

Role of Brazilian Amazon protected areas in climate change mitigation

Abstract: Protected areas (PAs) now shelter 54% of the remaining forests of the Brazilian Amazon and contain 56% of its forest carbon. However, the role of these PAs in reducing carbon fluxes to the atmosphere from deforestation and their associated costs are still uncertain. To fill this gap, we analyzed the effect of each of 595 Brazilian Amazon PAs on deforestation using a metric that accounts for differences in probability of deforestation in areas of pairwise comparison. We found that the three major categories of PA (indigenous land, strictly protected, and sustainable use) showed an inhibitory effect, on average, between 1997 and 2008. Of 206 PAs created after the year 1999, 115 showed increased effectiveness after their designation as protected. The recent expansion of PAs in the Brazilian Amazon was responsible for 37% of the region's total reduction in deforestation between 2004 and 2006 without provoking leakage. All PAs, if fully implemented, have the potential to avoid 8.0 ± 2.8 Pg of carbon emissions by 2050. Effectively implementing PAs in zones under high current or future anthropogenic threat offers high payoffs for reducing carbon emissions, and as a result should receive special attention in planning investments for regional conservation. Nevertheless, this strategy demands prompt and predictable resource streams. The Amazon PA network represents a cost of US$147 ± 53 billion (net present value) for Brazil in terms of forgone profits and investments needed for their consolidation. These costs could be partially compensated by an international climate accord that includes economic incentives for tropical countries that reduce their carbon emissions from deforestation and forest degradation.

Characterizing Graphene, Graphite, and Carbon Nanotubes by Raman Spectroscopy

Abstract: Recent advances in Raman spectroscopy for characterizing graphene, graphite, and carbon nanotubes are reviewed comparatively We first discuss the first-order and the double-resonance (DR) second-order Raman scattering mechanisms in graphene, which give rise to the most prominent Raman features Then, we review phonon-softening phenomena in Raman spectra as a function of gate voltage, which is known as the Kohn anomaly Finally, we review exciton-specific phenomena in the resonance Raman spectra of single-wall carbon nanotubes (SWNTs) Raman spectroscopy of SWNTs has been especially useful for understanding many fundamental properties of all sp2 carbons, given SWNTs can be either semiconducting or metallic depending on their geometric structure, which is denoted by two integers (n,m)

Epidemiology, Treatment, and Prevention of Human T-Cell Leukemia Virus Type 1-Associated Diseases

Abstract: Summary: Human T-cell leukemia virus type 1 (HTLV-1), the first human retrovirus to be discovered, is present in diverse regions of the world, where its infection is usually neglected in health care settings and by public health authorities. Since it is usually asymptomatic in the beginning of the infection and disease typically manifests later in life, silent transmission occurs, which is associated with sexual relations, breastfeeding, and blood transfusions. There are no prospects of vaccines, and screening of blood banks and in prenatal care settings is not universal. Therefore, its transmission is active in many areas such as parts of Africa, South and Central America, the Caribbean region, Asia, and Melanesia. It causes serious diseases in humans, including adult T-cell leukemia/lymphoma (ATL) and an incapacitating neurological disease (HTLV-associated myelopathy/tropical spastic paraparesis [HAM/TSP]) besides other afflictions such as uveitis, rheumatic syndromes, and predisposition to helminthic and bacterial infections, among others. These diseases are not curable as yet, and current treatments as well as new perspectives are discussed in the present review.

The Impact of Business Analytics on Supply Chain Performance

Abstract: The paper investigates the relationship between analytical capabilities in the plan, source, make and deliver area of the supply chain and its performance using information system support and business process orientation as moderators. Structural equation modeling employs a sample of 310 companies from different industries from the USA, Europe, Canada, Brazil and China. The findings suggest the existence of a statistically significant relationship between analytical capabilities and performance. The moderation effect of information systems support is considerably stronger than the effect of business process orientation. The results provide a better understanding of the areas where the impact of business analytics may be the strongest.

Regulation of leukocyte recruitment by the long pentraxin PTX3

Abstract: Pentraxins are a superfamily of conserved proteins involved in the acute-phase response and innate immunity. Pentraxin 3 (PTX3), a prototypical member of the long pentraxin subfamily, is a key component of the humoral arm of innate immunity that is essential for resistance to certain pathogens. A regulatory role for pentraxins in inflammation has long been recognized, but the underlying mechanisms remain unclear. Here we report that PTX3 bound P-selectin and attenuated neutrophil recruitment at sites of inflammation. PTX3 released from activated leukocytes functioned locally to dampen neutrophil recruitment and regulate inflammation. Antibodies have glycosylation-dependent regulatory effect on inflammation. Therefore, PTX3, which is an essential component of humoral innate immunity, and immunoglobulins share functional outputs, including complement activation, opsonization and, as shown here, glycosylation-dependent regulation of inflammation.

The impact of business analytics on supply chain performance

Abstract: The paper investigates the relationship between analytical capabilities in the plan, source, make and deliver area of the supply chain and its performance using information system support and business process orientation as moderators. Structural equation modeling employs a sample of 310 companies from different industries from the USA, Europe, Canada, Brazil and China. The findings suggest the existence of a statistically significant relationship between analytical capabilities and performance. The moderation effect of information systems support is considerably stronger than the effect of business process orientation. The results provide a better understanding of the areas where the impact of business analytics may be the strongest.

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

Abstract: Background and purpose: Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that induces anxiolytic- and antipsychotic-like effects in animal models. Effects of CBD may be mediated by the activation of 5-HT1A receptors. As 5-HT1A receptor activation may induce antidepressant-like effects, the aim of this work was to test the hypothesis that CBD would have antidepressant-like activity in mice as assessed by the forced swimming test. We also investigated if these responses depended on the activation of 5-HT1A receptors and on hippocampal expression of brain-derived neurotrophic factor (BDNF).

In vitro and in vivo experimental models for drug screening and development for Chagas disease

Abstract: Chagas disease, a neglected illness, affects nearly 12-14 million people in endemic areas of Latin America. Although the occurrence of acute cases sharply has declined due to Southern Cone Initiative efforts to control vector transmission, there still remain serious challenges, including the maintenance of sustainable public policies for Chagas disease control and the urgent need for better drugs to treat chagasic patients. Since the introduction of benznidazole and nifurtimox approximately 40 years ago, many natural and synthetic compounds have been assayed against Trypanosoma cruzi, yet only a few compounds have advanced to clinical trials. This reflects, at least in part, the lack of consensus regarding appropriate in vitro and in vivo screening protocols as well as the lack of biomarkers for treating parasitaemia. The development of more effective drugs requires (i) the identification and validation of parasite targets, (ii) compounds to be screened against the targets or the whole parasite and (iii) a panel of minimum standardised procedures to advance leading compounds to clinical trials. This third aim was the topic of the workshop entitled Experimental Models in Drug Screening and Development for Chagas Disease, held in Rio de Janeiro, Brazil, on the 25th and 26th of November 2008 by the Fiocruz Program for Research and Technological Development on Chagas Disease and Drugs for Neglected Diseases Initiative. During the meeting, the minimum steps, requirements and decision gates for the determination of the efficacy of novel drugs for T. cruzi control were evaluated by interdisciplinary experts and an in vitro and in vivo flowchart was designed to serve as a general and standardised protocol for screening potential drugs for the treatment of Chagas disease.

Cross-cultural adaptation and evaluation of the psychometric properties of the Falls Efficacy Scale - International Among Elderly Brazilians (FES-I-BRAZIL)

Abstract: Objectives: To culturally adapt the Falls Efficacy Scale - International (FES-I) and assess its psychometric properties in a sample of community-dwelling elderly Brazilians. Methods: The instrument was translated into Brazilian Portuguese and culturally adapted to the Brazilian population (FES-I-Brazil) as recommended by the Prevention of Falls Network Europe. FES-I-Brazil was applied to 163 elderly people (73.44±5.51 years), and the demographic data and history of falls were also collected. From this group, 58 participants were randomly distributed to evaluate reliability. The reliability was analyzed using the intraclass correlation coefficient (ICC) and the internal consistency, using Cronbach's alpha coefficient (α). The internal structure of FES-I-Brazil was evaluated by means of exploratory factor analysis. The logistic regression model was used to determine which tasks on the scale were more relevant for discriminating falls. To analyze the sensitivity and specificity of FES-I-Brazil, the receiver operating characteristic (ROC) curve was used. Results: The internal consistency of FES-I-Brazil was α=0.93, and the intra- and inter-examiner reliability were ICC=0.84 and 0.91, respectively. Factor analysis suggested two factors: concern about falling during social activities and activities of daily living (basic and instrumental), and postural control tasks. FES-I-Brazil scores ≥23 suggested an association with a previous history of sporadic falls, whereas scores ≥31 suggested an association with recurrent falls. Conclusions: FES-I-Brazil was shown to be semantically, linguistically and psychometrically appropriate to evaluate the fear of falling in the community-dwelling Brazilian elderly population.

Pressure Routing for Underwater Sensor Networks

Abstract: A SEA Swarm (Sensor Equipped Aquatic Swarm) is a sensor "cloud" that drifts with water currents and enables 4D (space and time) monitoring of local underwater events such as contaminants, marine life and intruders. The swarm is escorted at the surface by drifting sonobuoys that collect the data from underwater sensors via acoustic modems and report it in real-time via radio to a monitoring center. The goal of this study is to design an efficient anycast routing algorithm for reliable underwater sensor event reporting to any one of the surface sonobuoys. Major challenges are the ocean current and the limited resources (bandwidth and energy). In this paper, we address these challenges and propose HydroCast, a hydraulic pressure based anycast routing protocol that exploits the measured pressure levels to route data to surface buoys. The paper makes the following contributions: a novel opportunistic routing mechanism to select the subset of forwarders that maximizes greedy progress yet limiting co-channel interference; and an efficient underwater "dead end" recovery method that outperforms recently proposed approaches. The proposed routing protocols are validated via extensive simulations.

Pathogenesis of bovine brucellosis.

Abstract: Bovine brucellosis is one of the most important zoonotic diseases worldwide, and is of particular significance in developing countries. The disease, which results in serious economic losses due to late term abortion, stillborn and weakly calves, is caused by Gram negative coccobacilli bacteria of the genus Brucella. Lesions consist of necrotic placentitis and interstitial mastitis in pregnant cows, and fibrinous pleuritis with interstitial pneumonia in aborted fetuses and newborn calves. This article considers the pathogenesis of Brucella abortus and reviews the ability of the pathogen to invade phagocytic and non-phagocytic host cells, resist the acidified intraphagosomal environment, and inhibit phagosome-lysosome fusion. Significant aspects of innate and adaptive immunity against brucellosis are also discussed.

Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson's disease.

Abstract: The brain-derived neurotrophic factor (BDNF) is a potent inhibitor of apoptosis-mediated cell death and neurotoxin-induced degeneration of dopaminergic neurons. There is a growing body of evidence implicating BDNF in the pathogenesis of Parkinson’s disease (PD), suggesting it may eventually be used in the development of neuroprotective therapies for PD. The serum BDNF of 47 PD patients and of 23 control subjects was assessed, and serum BNDF levels were significantly decreased in PD patients when compared with controls (p = 0.046). Interestingly enough, BDNF correlated positively with a longer time span of the disease, as well as with the severity of the PD symptoms and with more advanced stages of the disease. Additionally, higher BDNF levels also correlated with poor balance as assessed by the Berg Balance Scale, more time spent at the Timed Up & Go Test, reduced speed of gait and shorter distance walked during the Six-Minute Walk Test. Our results corroborate the literature regarding the involvement of BDNF in PD. We hypothesize that lower BDNF levels in early stages of the disease may be associated with pathogenic mechanisms of PD. The increase of BDNF levels with the progression of the disease may be a compensatory mechanism in more advanced stages of PD.

A New and Fast Technique to Generate Offspring after Germ Cells Transplantation in Adult Fish: The Nile Tilapia (Oreochromis niloticus) Model

Abstract: Background Germ cell transplantation results in fertile recipients and is the only available approach to functionally investigate the spermatogonial stem cell biology in mammals and probably in other vertebrates. In the current study, we describe a novel non-surgical methodology for efficient spermatogonial transplantation into the testes of adult tilapia (O. niloticus), in which endogenous spermatogenesis had been depleted with the cytostatic drug busulfan. Methodology/Principal Findings Using two different tilapia strains, the production of fertile spermatozoa with donor characteristics was demonstrated in adult recipient, which also sired progeny with the donor genotype. Also, after cryopreservation tilapia spermatogonial cells were able to differentiate to spermatozoa in the testes of recipient fishes. These findings indicate that injecting germ cells directly into adult testis facilitates and enable fast generation of donor spermatogenesis and offspring compared to previously described methods. Conclusion Therefore, a new suitable methodology for biotechnological investigations in aquaculture was established, with a high potential to improve the production of commercially valuable fish, generate transgenic animals and preserve endangered fish species.

Accretion dynamics and disk evolution in NGC 2264: a study based on CoRoT photometric observations

Abstract: Context. The young cluster NGC 2264 was observed with the CoRoT satellite for 23 days uninterruptedly in March 2008 with unprecedented photometric accuracy. We present the first results of our analysis of the accreting population belonging to the cluster as observed by CoRoT. Aims. We search for possible light curve variability of the same nature as that observed in the classical T Tauri star AA Tau, which was attributed to a magnetically controlled inner disk warp. The inner warp dynamics is supposed to be directly associated with the interaction between the stellar magnetic field and the inner disk region. Methods. We analyzed the CoRoT light curves of 83 previously known classical T Tauri stars that belong to NGC 2264 classifying them according to their light-curve morphology. We also studied the CoRoT light-curve morphology as a function of a Spitzer -based classification of the star-disk systems. Results. The classification derived on the basis of the CoRoT light-curve morphology agrees very well with the Spitzer IRAC-based classification of the systems. The percentage of AA Tau-like light curves decreases as the inner disk dissipates, from 40% ± 10% in systems with thick inner disks to 36% ± 16% in systems with anemic disks and zero in naked photosphere systems. Indeed, 91% ± 29% of the CTTS with naked photospheres exhibit pure spot-like variability, while only 18% ± 7% of the thick disk systems do so, presumably those seen at low inclination and thus free of variable obscuration. Conclusions. AA Tau-like light curves are found to be fairly common, with a frequency of at least ~30 to 40% in young stars with inner dusty disks. The temporal evolution of the light curves indicates that the structure of the inner disk warp, located close to the corotation radius and responsible for the obscuration episodes, varies over a timescale of a few (~1–3) rotational periods. This probably reflects the highly dynamical nature of the star-disk magnetospheric interaction.

Glutathione S-transferases: an overview in cancer research.

Abstract: Importance of the field: The Glutathione S-transferases (GSTs) have advanced beyond the classic view of their role in metabolism and are encouraging scientists to assess new approaches to cancer risk characterization and chemotherapy resistance and are opening up exciting possibilities in drug discovery. Areas covered in this review: In this review, the most recent knowledge about the impact of GST genetic polymorphisms in human’s cancer susceptibility, ethnic differences in the effects of risk factors and the rise of the GSTs as important targets for drug development are presented. In this context, the ethnic distribution of GST alleles in different populations, which is an important concept that is being incorporated in epidemiologic studies of cancer risk and environmental exposure, was also evaluated. We present upto-date information about the new generation of GST-activated cytotoxic prodrugs based on GST overexpression in tumor-acquired drug resistance and the newest results of clinical trials. What the reader will gain: A critical approach of the major advances in research of GST, underlining the new advances of GST genes polymorphisms in cancer susceptibility and target for therapeutic intervention. Take home message: Although polygenic factors are involved in increased risk of cancer, the interindividual GST variability plays a central role in reduce cells exposure to carcinogens.

Complexity-entropy causality plane: A useful approach to quantify the stock market inefficiency

Abstract: The complexity-entropy causality plane has been recently introduced as a powerful tool for discriminating Gaussian from non-Gaussian process and different degrees of correlations [O.A. Rosso, H.A. Larrondo, M.T. Martin, A. Plastino, M.A. Fuentes, Distinguishing noise from chaos, Phys. Rev. Lett. 99 (2007) 154102]. We propose to use this representation space to distinguish the stage of stock market development. Our empirical results demonstrate that this statistical physics approach is useful, allowing a more refined classification of stock market dynamics.

Indigenous Lands, Protected Areas, and Slowing Climate Change

Abstract: Recent climate talks in Copenhagen reaffirmed the crucial role of reducing emissions from deforestation and degradation (REDD). Creating and strengthening indigenous lands and other protected areas represents an effective, practical, and immediate REDD strategy that addresses both biodiversity and climate crises at once.