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Institution

Universidade Federal de Minas Gerais

EducationBelo Horizonte, Minas Gerais, Brazil
About: Universidade Federal de Minas Gerais is a education organization based out in Belo Horizonte, Minas Gerais, Brazil. It is known for research contribution in the topics: Population & Immune system. The organization has 41631 authors who have published 75688 publications receiving 1249905 citations.


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Journal ArticleDOI
TL;DR: A significant influence of the genetic polymorphism of infecting T. cruzi populations in the pathogenesis of chronic Chagas disease is indicated by the results of a low-stringency single specific primer polymerase chain reaction test.

156 citations

Journal ArticleDOI
TL;DR: “.” ˛˚ ˛ ˜ˇ 2 ˆ````龍左 𝚘 , 7˚, 7˘ ݘ ンジャック, ݚ വ’ “’Benedictine’s Law”, 2 January 2017.
Abstract: ˝ ˛˚ ˛ ˜ˇ 2 ˆ ˜˚  / $  &  B@H/#$˝ !" #˛ $ 2 $˚ ˘ , 7˘ 1  0 =˙1B˛ H  " E  "  $ % & ’$ ˛ 2 D  0 @    ˚   "˜7 ?’ H ˚ 2 &’ # ˝˛ ˚ ( "  2 ˆ $ ˘˚  B˛ H   ˇ ˝˛) * ˛˛ 2 $˚ ˘ , 7˘ 1  0 =˙1B˛ H  " E 1"  $ ˘    " $˚ ˝+ ˛,- ˘ #    ˚ 5 A   0 =˙1B˛ H  " E ˚." / 2 H  & 2 B#$ " $ "  $ ˚ 0 ˚˛˛1 2 $$&( B˛ H  " E A #   $ 1"  $ 2/ 3 2 @   ˜ 2 H  &  B˛ H  /ˆ˝ # 1"  $ 2/ " 2      # / # $ ˝ 2 $42 (˛ 2 ?ˆ  85˛ & ˚  2 # / #  ˇ ˜  ˛ ˇ 5 6( 2 $˚ ˘ , 7˘ 1  0 =˙1B˛ H  " E A "  $ ˜ ˝ ˛˜76 ( 2  ˘ H 2 # / # # $  # $ , , ˇ ˛˜ˇ 2 H   , ˆˇ $ ˛  " E ,/˝˛( ’ 2 $˚ ˘ , 7˘ 1  0 =˙ 2 B˛ H  " E  #    ˚ 5 , / 2 #)# $˚ ˘ @   #1, 2 &’ # 3.)+ 8 2 ?ˆ  B˛5 $ / 2 B˛ /  " E 3 + ˚ 2  "˜7 ?’ H ˚ 2 &’ # 3+ ˛’˛˘ B˛ H  " (  @9: 2 2  # ˛ 2 B˛ H   ˇ .) +  2 $˜˝ B˛  0 ˙$B 2 #   # $  .;  2  "˜7 ?’ H ˚ 2 &’ # A B˛ /  " E  ’"? ˛ 2  # ˛ 2 B˛ H   ˇ 1"  $ ( ˝+3@@ 2  "˜7 ?’ H ˚ 2 #)# &’ # (A’# *ˇ˝ 2 ?ˆ  & ˆ  " ˆˇ  $  # -  #&#˙"EA $˚ ˘ , 7˘ 1  0 =˙ 2 B˛ H  " E * ˚/6˚ 2 ?ˆ  B˛5 E   2 ’˘ B˛ H  $ 5*9 6 2  # ˛ 2 B˛ H   ˇ B/3 8 (ˇ6" ˛ 2 ˛  ˜ ?ˆ  ˝ H  & B˛ # $  ’ 2 ?ˆ  #  0 $ ˇ $ ,˚ # / # 2 "# "  $ ) <˜ / 2 ˆ $ ˘˚  B˛ H  $ 5A ˘ ˜. #$ ˚/’˛ 2      # # & ˝ˆ " E 1"  $  (? 2  # ˛ 2 B˛ H   ˇ 1"  $ C.(˝ ˛ 2 H  &  ˆ $ ˘˚  B˛ H  & ( C , 2      2 )/ 2 # / # # $ 1"  $ &$< ˛ 2  "˜7 #1, # / # # $ A H  & B˛ # $ 4 ˛ D & ˚ ˇ ˘ H  , ˚ H - & J KL $ $

156 citations

Journal ArticleDOI
TL;DR: It is concluded that nodulation in Mimosa is a generic character, and that the preferred symbionts of Brazilian species are Burkholderia, in the first study to demonstrate N(2) fixation by beta-rhizobial symbioses in the field.
Abstract: P>An extensive survey of nodulation in the legume genus Mimosa was undertaken in two major biomes in Brazil, the Cerrado and the Caatinga, in both of which there are high degrees of endemicity of the genus. Nodules were collected from 67 of the 70 Mimosa spp. found. Thirteen of the species were newly reported as nodulating. Nodules were examined by light and electron microscopy, and all except for M. gatesiae had a structure typical of effective Mimosa nodules. The endosymbiotic bacteria in nodules from all of the Mimosa spp. were identified as Burkholderia via immunolabelling with an antibody against Burkholderia phymatum STM815. Twenty of the 23 Mimosa nodules tested were shown to contain nitrogenase by immunolabelling with an antibody to the nitrogenase Fe- (nifH) protein, and using the delta 15N (15N natural abundance) technique, contributions by biological N-2 fixation of up to 60% of total plant N were calculated for Caatinga Mimosa spp. It is concluded that nodulation in Mimosa is a generic character, and that the preferred symbionts of Brazilian species are Burkholderia. This is the first study to demonstrate N-2 fixation by beta-rhizobial symbioses in the field.

156 citations

Journal ArticleDOI
TL;DR: The binding of the new complexes to DNA, their capacity to cleave it, their cytotoxic activity, and uptake in tumoral cells are evaluated; they are among the most potent DNA cleavage agents reported so far.
Abstract: This paper reports on the synthesis and characterization of two new ternary copper(II) complexes: [Cu(doxycycline)(1,10-phenanthroline)(H(2)O)(ClO(4))](ClO(4)) (1) and [Cu(tetracycline)(1,10-phenanthroline)(H(2)O)(ClO(4))](ClO(4)) (2). These compounds exhibit a distorted tetragonal geometry around copper, which is coordinated to two bidentate ligands, 1,10-phenanthroline and tetracycline or doxycyline, a water molecule, and a perchlorate ion weakly bonded in the axial positions. In both compounds, copper(II) binds to tetracyclines via the oxygen of the hydroxyl group and oxygen of the amide group at ring A and to 1,10-phenanthroline via its two heterocyclic nitrogens. We have evaluated the binding of the new complexes to DNA, their capacity to cleave it, their cytotoxic activity, and uptake in tumoral cells. The complexes bind to DNA preferentially by the major groove, and then cleave its strands by an oxidative mechanism involving the generation of ROS. The cleavage of DNA was inhibited by radical inhibitors and/or trappers such as superoxide dismutase, DMSO, and the copper(I) chelator bathocuproine. The enzyme T4 DNA ligase was not able to relegate the products of DNA cleavage, which indicates that the cleavage does not occur via a hydrolytic mechanism. Both complexes present an expressive plasmid DNA cleavage activity generating single- and double-strand breaks, under mild reaction conditions, and even in the absence of any additional oxidant or reducing agent. In the same experimental conditions, [Cu(phen)(2)](2+) is approximately 100-fold less active than our complexes. These complexes are among the most potent DNA cleavage agents reported so far. Both complexes inhibit the growth of K562 cells with the IC(50) values of 1.93 and 2.59 μmol L(-1) for compounds 1 and 2, respectively. The complexes are more active than the free ligands, and their cytotoxic activity correlates with intracellular copper concentration and the number of Cu-DNA adducts formed inside cells.

156 citations

Journal ArticleDOI
TL;DR: Examining the prevalence and clinical features of Sydenham's chorea, a well‐recognized expression of RF, examined 50 consecutive patients with RF seen at the Pediatric Cardiology Clinic, finding that SC remains an important cause of chorea in countries plagued by RF.
Abstract: Rheumatic fever (RF) remains a significant public health problem in developing countries. Although its incidence has been declining in developed areas, several outbreaks of RF have been identified in the United States since 1985. To study the prevalence and clinical features of Sydenham's chorea (SC), a well-recognized expression of RF, we examined 50 consecutive patients with RF seen at our Pediatric Cardiology Clinic. Chorea was rated on a scale of 0-4 (0 = no chorea; and 4 = severe chorea, patient unable to walk). Chorea, active or in remission, occurred in 13 patients (26%). The male-to-female ratio was 1.08 among the total population and 0.86 among the SC group. The mean age of the 50 patients at onset of RF was 8.4 years and the standard deviation (SD) 3.1 years. Carditis was diagnosed in 84% of patients with and without chorea, but arthritis was more common in the latter group (83.8%) than in the SC group (30.8%). The mean age at onset of SC was 9.2 years (SD 2.7). Involuntary movement, noticed by nine patients, was the most common initial symptom. Chorea went into remission in eight patients after 9.9 months (SD 13.4). Chorea was rated 3 in ten patients, 1 in two patients, and 4 in one patient. Among the five patients with active SC, three had hemichorea and two had generalized chorea. We recognized abnormal saccades in 80% of patients with active chorea, whereas just 13.5% of patients without chorea displayed this abnormality. SC remains an important cause of chorea in countries plagued by RF.

156 citations


Authors

Showing all 42077 results

NameH-indexPapersCitations
Michael Marmot1931147170338
Pulickel M. Ajayan1761223136241
Alan D. Lopez172863259291
Jens Nielsen1491752104005
Mildred S. Dresselhaus136762112525
Jing Kong12655372354
Mauricio Terrones11876061202
Michael Brammer11842446763
Terence G. Langdon117115861603
Caroline A. Sabin10869044233
Michael Brauer10648073664
Michael Bader10373537525
Michael S. Strano9848060141
Pablo Jarillo-Herrero9124539171
Riichiro Saito9150248869
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023111
2022624
20215,708
20205,955
20195,269
20185,020