Institution
Universidade Federal de Minas Gerais
Education•Belo Horizonte, Minas Gerais, Brazil•
About: Universidade Federal de Minas Gerais is a education organization based out in Belo Horizonte, Minas Gerais, Brazil. It is known for research contribution in the topics: Population & Immune system. The organization has 41631 authors who have published 75688 publications receiving 1249905 citations.
Papers published on a yearly basis
Papers
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TL;DR: CaMKII inhibition substantially prevented maladaptive remodeling from excessive βAR stimulation and myocardial infarction, and induced balanced changes in excitation-contraction coupling that preserved baseline and βAR-stimulated physiological increases in cardiac function.
Abstract: Beta-adrenergic receptor (betaAR) stimulation increases cytosolic Ca(2+) to physiologically augment cardiac contraction, whereas excessive betaAR activation causes adverse cardiac remodeling, including myocardial hypertrophy, dilation and dysfunction, in individuals with myocardial infarction. The Ca(2+)-calmodulin-dependent protein kinase II (CaMKII) is a recently identified downstream element of the betaAR-initiated signaling cascade that is linked to pathological myocardial remodeling and to regulation of key proteins involved in cardiac excitation-contraction coupling. We developed a genetic mouse model of cardiac CaMKII inhibition to test the role of CaMKII in betaAR signaling in vivo. Here we show CaMKII inhibition substantially prevented maladaptive remodeling from excessive betaAR stimulation and myocardial infarction, and induced balanced changes in excitation-contraction coupling that preserved baseline and betaAR-stimulated physiological increases in cardiac function. These findings mark CaMKII as a determinant of clinically important heart disease phenotypes, and suggest CaMKII inhibition can be a highly selective approach for targeting adverse myocardial remodeling linked to betaAR signaling.
563 citations
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TL;DR: In this article, the authors developed novel polyvinyl alcohol (PVA)/poly(ethylene glycol) (PEG) hydrogel blends and PVA-derived organic-inorganic hybrid materials and performed nanostructural characterizations.
560 citations
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08 Oct 2000TL;DR: In this article, a small-signal analysis for parallel-connected inverters in stand-alone AC supply systems is presented, which is based on frequency and voltage droops, which depends on the local variable measurements and does not need control interconnections.
Abstract: This paper presents a small-signal analysis for parallel-connected inverters in stand-alone AC supply systems. The control technique of the inverters is based on frequency and voltage droops, which depends on the local variable measurements and does not need control interconnections. Simulation and experimental results show that the system is well represented by the small-signal model. Some root locus plots for the system are provided, which make the stability studies and design easier.
558 citations
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TL;DR: The authors' studies show a clear division of T. cruzi into two major lineages presenting a high phylogenetic divergence and hypotheses are discussed to explain the origin of the two lineages as well as isolates that are hybrid for group 1 and 2 rDNA markers.
548 citations
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TL;DR: The double resonance Raman process provides new assignments for the dispersive and nondispersive features observed in the Raman spectra of disordered graphite and carbon nanotubes, some features having been incorrectly assigned previously, or not assigned at all.
Abstract: The phonon dispersion relations of graphite can be probed over a wide range of the Brillouin zone by double resonance Raman spectroscopy. The double resonance Raman process provides us with new assignments for the dispersive and nondispersive features observed in the Raman spectra of disordered graphite and carbon nanotubes, some features having been incorrectly assigned previously, or not assigned at all.
543 citations
Authors
Showing all 42077 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Marmot | 193 | 1147 | 170338 |
Pulickel M. Ajayan | 176 | 1223 | 136241 |
Alan D. Lopez | 172 | 863 | 259291 |
Jens Nielsen | 149 | 1752 | 104005 |
Mildred S. Dresselhaus | 136 | 762 | 112525 |
Jing Kong | 126 | 553 | 72354 |
Mauricio Terrones | 118 | 760 | 61202 |
Michael Brammer | 118 | 424 | 46763 |
Terence G. Langdon | 117 | 1158 | 61603 |
Caroline A. Sabin | 108 | 690 | 44233 |
Michael Brauer | 106 | 480 | 73664 |
Michael Bader | 103 | 735 | 37525 |
Michael S. Strano | 98 | 480 | 60141 |
Pablo Jarillo-Herrero | 91 | 245 | 39171 |
Riichiro Saito | 91 | 502 | 48869 |