Institution
Universidade Federal de Minas Gerais
Education•Belo Horizonte, Minas Gerais, Brazil•
About: Universidade Federal de Minas Gerais is a education organization based out in Belo Horizonte, Minas Gerais, Brazil. It is known for research contribution in the topics: Population & Context (language use). The organization has 41631 authors who have published 75688 publications receiving 1249905 citations.
Topics: Population, Context (language use), Medicine, Immune system, Health care
Papers published on a yearly basis
Papers
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TL;DR: The results indicate that osteoblast vacuole formation was due to high silicon contents in the dissolution of BG60S and can suggest that despite the vacuoles formation, there is no significant alteration in the bioceramic cell interaction.
480 citations
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Brigham and Women's Hospital1, Memorial Hermann Texas Medical Center2, University of Cologne3, University of Chicago4, Duke University5, University of California, Davis6, Henry Ford Hospital7, Stanford University8, Fred Hutchinson Cancer Research Center9, University of Würzburg10, University of Strasbourg11, Katholieke Universiteit Leuven12, Rambam Health Care Campus13, University of Alabama at Birmingham14, Masaryk University15, Sheba Medical Center16, Universidade Federal de Minas Gerais17, Charité18, University of Minnesota19, Khon Kaen University20, Prince of Songkla University21, American University of Beirut22, Center for Global Development23
TL;DR: Isavuconazole showed activity against mucormycosis with efficacy similar to amphotericin B, and can be used for treatment of mucormYcosis and is well tolerated.
Abstract: Summary Background Mucormycosis is an uncommon invasive fungal disease with high mortality and few treatment options. Isavuconazole is a triazole active in vitro and in animal models against moulds of the order Mucorales. We assessed the efficacy and safety of isavuconazole for treatment of mucormycosis and compared its efficacy with amphotericin B in a matched case-control analysis. Methods In a single-arm open-label trial (VITAL study), adult patients (≥18 years) with invasive fungal disease caused by rare fungi, including mucormycosis, were recruited from 34 centres worldwide. Patients were given isavuconazole 200 mg (as its intravenous or oral water-soluble prodrug, isavuconazonium sulfate) three times daily for six doses, followed by 200 mg/day until invasive fungal disease resolution, failure, or for 180 days or more. The primary endpoint was independent data review committee-determined overall response—ie, complete or partial response (treatment success) or stable or progressive disease (treatment failure)—according to prespecified criteria. Mucormycosis cases treated with isavuconazole as primary treatment were matched with controls from the FungiScope Registry, recruited from 17 centres worldwide, who received primary amphotericin B-based treatment, and were analysed for day-42 all-cause mortality. VITAL is registered with ClinicalTrials.gov, number NCT00634049. FungiScope is registered with ClinicalTrials.gov, number NCT01731353. Findings Within the VITAL study, from April 22, 2008, to June 21, 2013, 37 patients with mucormycosis received isavuconazole for a median of 84 days (IQR 19–179, range 2–882). By day 42, four patients (11%) had a partial response, 16 (43%) had stable invasive fungal disease, one (3%) had invasive fungal disease progression, three (8%) had missing assessments, and 13 (35%) had died. 35 patients (95%) had adverse events (28 [76%] serious). Day-42 crude all-cause mortality in seven (33%) of 21 primary-treatment isavuconazole cases was similar to 13 (39%) of 33 amphotericin B-treated matched controls (weighted all-cause mortality: 33% vs 41%; p=0·595). Interpretation Isavuconazole showed activity against mucormycosis with efficacy similar to amphotericin B. Isavuconazole can be used for treatment of mucormycosis and is well tolerated. Funding Astellas Pharma Global Development, Basilea Pharmaceutica International.
478 citations
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TL;DR: In this paper, the adsorption features of activated carbon and the magnetic properties of iron oxides were combined in a composite to produce magnetic adsorbents, which can be used as adsorbent for a wide range of contaminants in water and can subsequently be removed from the medium by simple magnetic procedure.
477 citations
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Royal Botanic Garden Edinburgh1, National Autonomous University of Mexico2, University of Edinburgh3, National Agrarian University4, Smithsonian Conservation Biology Institute5, Universidade Federal de Minas Gerais6, National University of Rosario7, Pontificia Universidad Católica del Ecuador8, Spanish National Research Council9, National Museum of Natural History10, University of Los Andes11, South Colombian University12, University of Atlántico13, Venezuelan Institute for Scientific Research14, Arizona State University15, Alexander von Humboldt Biological Resources Research Institute16, Del Rosario University17, International Institute of Minnesota18, University of Antioquia19, District University of Bogotá20, National University of Salta21, Bangor University22, University of the West Indies23, Universidad del Tolima24, National University of Colombia25, Royal Botanic Gardens26, University of Pamplona27
TL;DR: Using 835 inventories covering 4660 species of woody plants, marked floristic turnover among inventories and regions indicates that numerous conservation areas across many countries will be needed to protect the full diversity of tropical dry forests.
Abstract: Seasonally dry tropical forests are distributed across Latin America and the Caribbean and are highly threatened, with less than 10% of their original extent remaining in many countries. Using 835 inventories covering 4660 species of woody plants, we show marked floristic turnover among inventories and regions, which may be higher than in other neotropical biomes, such as savanna. Such high floristic turnover indicates that numerous conservation areas across many countries will be needed to protect the full diversity of tropical dry forests. Our results provide a scientific framework within which national decision-makers can contextualize the floristic significance of their dry forest at a regional and continental scale.
473 citations
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TL;DR: In the case of Brazil, a sharp and widespread fertility decline began by the end of the 1960s and an accelerated population aging process can thus be expected as mentioned in this paper, which will necessarily be faster and with deeper structural changes, demographically speaking, than in First World countries, for two reasons: fertility decline in Brazil was faster, and it took place in a population with a younger age structure.
Abstract: Contrary to common sense, the population aging process is due to the decline in fertility rather than mortality. The aging process began around the end of the 19th century in a number of Western European countries, expanded to the rest of the so-called First World over the past century, and reached several Third World countries afterwards, including Brazil over the last decades. In the Brazilian case, a sharp and widespread fertility decline began by the end of the 1960s, and an accelerated population aging process can thus be expected. This process will necessarily be faster and with deeper structural changes, demographically speaking, than in First World countries, for two reasons: the fertility decline in Brazil was faster, and it took place in a population with a younger age structure.
473 citations
Authors
Showing all 42077 results
Name | H-index | Papers | Citations |
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Michael Marmot | 193 | 1147 | 170338 |
Pulickel M. Ajayan | 176 | 1223 | 136241 |
Alan D. Lopez | 172 | 863 | 259291 |
Jens Nielsen | 149 | 1752 | 104005 |
Mildred S. Dresselhaus | 136 | 762 | 112525 |
Jing Kong | 126 | 553 | 72354 |
Mauricio Terrones | 118 | 760 | 61202 |
Michael Brammer | 118 | 424 | 46763 |
Terence G. Langdon | 117 | 1158 | 61603 |
Caroline A. Sabin | 108 | 690 | 44233 |
Michael Brauer | 106 | 480 | 73664 |
Michael Bader | 103 | 735 | 37525 |
Michael S. Strano | 98 | 480 | 60141 |
Pablo Jarillo-Herrero | 91 | 245 | 39171 |
Riichiro Saito | 91 | 502 | 48869 |