Institution
Universidade Federal do Pampa
Education•Bagé, Brazil•
About: Universidade Federal do Pampa is a education organization based out in Bagé, Brazil. It is known for research contribution in the topics: Population & Oxidative stress. The organization has 3498 authors who have published 4494 publications receiving 29796 citations.
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors report on the micro-Raman spectroscopy of monolayer, bilayer, trilayer and many layers of graphene (graphite) bombarded by low-energy argon ions with different doses.
Abstract: We report on the micro-Raman spectroscopy of monolayer, bilayer, trilayer, and many layers of graphene (graphite) bombarded by low-energy argon ions with different doses. The evolution of peak frequencies, intensities, linewidths, and areas of the main Raman bands of graphene is analyzed as function of the distance between defects and number of layers. We describe the disorder-induced frequency shifts and the increase in the linewidth of the Raman bands by means of a spatial-correlation model. Also, the evolution of the relative areas ${A}_{D}/{A}_{G}$, ${A}_{{D}^{\ensuremath{'}}}/{A}_{G}$, and ${A}_{{G}^{\ensuremath{'}}}/{A}_{G}$ is described by a phenomenological model. The present results can be used to fully characterize disorder in graphene systems.
671 citations
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TL;DR: This review focuses on the neurodegenerative mechanisms and effects of Fe, Mn and Hg, addressing the main sources of exposure to these metals, their transport mechanisms into the brain, and therapeutic modalities to mitigate their neurotoxic effects.
446 citations
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TL;DR: It is indicated that mercury exposure, even at low doses, affects endothelial and cardiovascular function, and the reference values defining the limits for the absence of danger should be reduced.
Abstract: Environmental contamination has exposed humans to various metal agents, including mercury. This exposure is more common than expected, and the health consequences of such exposure remain unclear. For many years, mercury was used in a wide variety of human activities, and now, exposure to this metal from both natural and artificial sources is significantly increasing. Many studies show that high exposure to mercury induces changes in the central nervous system, potentially resulting in irritability, fatigue, behavioral changes, tremors, headaches, hearing and cognitive loss, dysarthria, incoordination, hallucinations, and death. In the cardiovascular system, mercury induces hypertension in humans and animals that has wide-ranging consequences, including alterations in endothelial function. The results described in this paper indicate that mercury exposure, even at low doses, affects endothelial and cardiovascular function. As a result, the reference values defining the limits for the absence of danger should be reduced.
297 citations
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TL;DR: An important finding of this study was the advantage of phylogenetic approaches for examining microbial communities with low sequence coverage, if the environments being compared were closely related, and a deeper sequencing would be necessary to detect the variation in the microbial composition.
271 citations
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TL;DR: It is reported that exposure to Mn may arise from environmental sources, occupational settings, food, total parenteral nutrition (TPN), methcathinone drug abuse or even genetic factors, such as mutation in the transporter SLC30A10.
Abstract: Manganese (Mn) is an essential heavy metal. However, Mn’s nutritional aspects are paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent advances in identifying mechanisms of Mn uptake and its molecular actions in the brain as well as promising neuroprotective strategies. The authors focused on reporting findings regarding Mn transport mechanisms, Mn effects on cholinergic system, behavioral alterations induced by Mn exposure and studies of neuroprotective strategies against Mn intoxication. We report that exposure to Mn may arise from environmental sources, occupational settings, food, total parenteral nutrition (TPN), methcathinone drug abuse or even genetic factors, such as mutation in the transporter SLC30A10. Accumulation of Mn occurs mainly in the basal ganglia and leads to a syndrome called manganism, whose symptoms of cognitive dysfunction and motor impairment resemble Parkinson’s disease (PD). Various neurotransmitter systems may be impaired due to Mn, especially dopaminergic, but also cholinergic and GABAergic. Several proteins have been identified to transport Mn, including divalent metal tranporter-1 (DMT-1), SLC30A10, transferrin and ferroportin and allow its accumulation in the central nervous system. Parallel to identification of Mn neurotoxic properties, neuroprotective strategies have been reported, and these include endogenous antioxidants (for instance, vitamin E), plant extracts (complex mixtures containing polyphenols and non-characterized components), iron chelating agents, precursors of glutathione (GSH), and synthetic compounds that can experimentally afford protection against Mn-induced neurotoxicity.
233 citations
Authors
Showing all 3527 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pietro Sampaio Baruselli | 45 | 332 | 7448 |
Ana Elisa Bauer de Camargo Silva | 37 | 172 | 5309 |
Elina Bastos Caramão | 36 | 171 | 4498 |
Aline Augusti Boligon | 34 | 347 | 5716 |
Cristiano Ricardo Jesse | 33 | 108 | 3024 |
Flávio A. Pavan | 31 | 60 | 3514 |
Cristina Ribeiro de Barros Cardoso | 30 | 88 | 3184 |
Luiz Fernando Wurdig Roesch | 30 | 99 | 4883 |
Daiana Silva Ávila | 29 | 107 | 2730 |
Jeferson Luis Franco | 29 | 108 | 2887 |
Paulo Bayard Dias Gonçalves | 29 | 200 | 2807 |
Mauro Schneider Oliveira | 28 | 106 | 2078 |
Ana Flávia Furian | 27 | 88 | 1838 |
Marina Prigol | 26 | 88 | 1662 |
Nilda Vargas Barbosa | 26 | 90 | 2154 |