Institution
Universidade Positivo
Education•Curitiba, Brazil•
About: Universidade Positivo is a education organization based out in Curitiba, Brazil. It is known for research contribution in the topics: Population & Biodiversity. The organization has 1290 authors who have published 1237 publications receiving 9335 citations. The organization is also known as: Positive University.
Papers published on a yearly basis
Papers
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TL;DR: An important role for the serotonergic system in the anxiolytic-like effect of lavender essential oil is indicated, and changes in the pharmacologically induced serotonin syndrome are evaluated.
123 citations
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TL;DR: Four individuals with ataxic cerebral palsy likely due to de novo dominant mutations associated with increased paternal age are described and investigated for genetic causes before the disorder is ascribed to asphyxia.
Abstract: Cerebral palsy is a sporadic disorder with multiple likely aetiologies, but frequently considered to be caused by birth asphyxia. Genetic investigations are rarely performed in patients with cerebral palsy and there is little proven evidence of genetic causes. As part of a large project investigating children with ataxia, we identified four patients in our cohort with a diagnosis of ataxic cerebral palsy. They were investigated using either targeted next generation sequencing or trio-based exome sequencing and were found to have mutations in three different genes, KCNC3, ITPR1 and SPTBN2. All the mutations were de novo and associated with increased paternal age. The mutations were shown to be pathogenic using a combination of bioinformatics analysis and in vitro model systems. This work is the first to report that the ataxic subtype of cerebral palsy can be caused by de novo dominant point mutations, which explains the sporadic nature of these cases. We conclude that at least some subtypes of cerebral palsy may be caused by de novo genetic mutations and patients with a clinical diagnosis of cerebral palsy should be genetically investigated before causation is ascribed to perinatal asphyxia or other aetiologies.
122 citations
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TL;DR: Examining the global occurrence of erythromycin in coastal and marine systems across large geographic regions indicated that the likelihood of exceeding the ERY PNEC for ABR in effluents was markedly high in Asia, followed by Europe and North America.
115 citations
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TL;DR: In this paper, the authors describe different pretreatment strategies to promote the delignification of sugarcane bagasse by thermo-chemical and biological processes, which is one of the most critical steps in the process of converting biomass to fermentable sugars.
Abstract: The valorization of agro-residues by biological routes is a key technology that contributes to the development of sustainable processes and the generation of value-added products. Sugarcane bagasse is an agro-residue generated by the sugar and alcohol industry in Brazil (186 million tons per year), composed essentially of cellulose (32-44%), hemicellulose (27-32%) and lignin (19-24%). The conversion of sugarcane bagasse into fermentable sugars requires essentially two steps: pretreatment and hydrolysis. The aim of the pretreatment is to separate the lignin and break the structure of lignocellulose, and it is one of the most critical steps in the process of converting biomass to fermentable sugars. The aim of this review is to describe different pretreatment strategies to promote the delignification of the sugarcane bagasse by thermo-chemical and biological processes.
109 citations
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TL;DR: The effectiveness of environmental impact assessment (EIA) is an important topic in EIA literature as mentioned in this paper, where the manifold term "effectiveness" has been delineated into four dimensions: Procedural, substantive, transactive, and normative.
109 citations
Authors
Showing all 1301 results
Name | H-index | Papers | Citations |
---|---|---|---|
Felix Sharipov | 41 | 176 | 5258 |
Paolo R. Salvalaggio | 31 | 92 | 3344 |
Vanete Thomaz Soccol | 30 | 119 | 5773 |
Vanete Thomaz-Soccol | 27 | 118 | 2990 |
Erika Calvano Küchler | 22 | 184 | 1992 |
Susan Grace Karp | 22 | 63 | 2379 |
Gisele Maria Correr | 21 | 118 | 1504 |
Luciano Rossoni | 21 | 96 | 2012 |
Clóvis L. Machado-da-Silva | 20 | 48 | 972 |
Carla Castiglia Gonzaga | 20 | 153 | 1692 |
Renato Nisihara | 19 | 141 | 1400 |
Juliana Rodrigues | 19 | 59 | 1709 |
Juliana Feltrin de Souza | 19 | 77 | 1237 |
Luiz Gustavo Lacerda | 18 | 58 | 768 |
Adilson Yoshio Furuse | 18 | 94 | 985 |