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Institution

Universidade São Judas Tadeu

EducationSão Paulo, Brazil
About: Universidade São Judas Tadeu is a education organization based out in São Paulo, Brazil. It is known for research contribution in the topics: Aerobic exercise & Baroreflex. The organization has 736 authors who have published 852 publications receiving 4782 citations.


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TL;DR: The sections in this article are: Cardiovascular Gap Junction Proteins, Genetic and Somatic Disease States in Which Gap Junction Expression or Function is Altered, and Properties of Gap Junctions Evaluated in Cardiovascular Cells.
Abstract: The sections in this article are: 1 Cardiovascular Gap Junction Proteins 11 Ultrastructural Features 12 Higher Resolution Through Projection Images 13 The Connexin Multigene Family 14 Connexin and Connexon Topology 15 Regional Connexin Expression in the Cardiovascular System 16 Why Are There Multiple Cardiovascular Connexins? 2 Macroscopic Organization of the Heart (Cables, Bricks, and Textures) 21 Gap Junction Organization within the Tissue 22 Modeling Tissue Connections 23 Optical Imaging of Patterned Cell Cultures 24 Microscopic and Macroscopic Discontinuities 3 Regulation of Gap Junction Expression, Formation, and Degradation 31 Life and Death of Gap Junctions 32 Long-Term Changes in Gap Junction Expression 33 Transcriptional Regulation of Cardiac Gap Junction Genes 4 Functional Properties of Cardiovascular Gap Junctions 41 Cardiovascular Gap Junctions Are K+, Ca2+, and Second Messenger Channels 42 Biophysical Properties of Junctional Channels 43 Gating of Gap Junctional Channels by Transjunctional Voltage 44 Properties of Specific Connexins Expressed in Exogenous Systems 45 Properties of Gap Junctions Evaluated in Cardiovascular Cells 46 Gating of Gap Junctions by Other Stimuli 5 Genetic and Somatic Disease States in Which Gap Junction Expression or Function is Altered 51 Somatic Cardiac Abnormalities 52 Reversed Physiology: Inferring Gene Function from Its Absence in Knockout Mice

10 citations

Journal ArticleDOI
TL;DR: The results suggest that the experimental model with low-intensity exercise (walking) seems to be more particularly recommended for preventing morphological and metabolic disorders occurring in the MS.
Abstract: Introduction Metabolic syndrome (MS) comprises several metabolic disorders that are risk factors for cardiovascular disease and has its source connected to the accumulation of visceral adipose tissue (VAT) and development of insulin resistance. Despite studies showing beneficial results of exercise on several risk factors for cardiovascular disease, studies evaluating the effects of different intensities of exercise training on the pancreas with experimental models are scarce. Methods In total, 20 Wistar rats were used, divided into four groups: control (C), metabolic syndrome (MS and without exercise), metabolic syndrome and practice of walking (MSWalk), and metabolic syndrome and practice of running (MSRun). The applied procedures were induction of MS by fructose in drinking water; experimental protocol of walking and running; weighing of body mass and VAT; sacrifice of animals with blood collection and removal of organs and processing of samples for light microscopy using the analysis of volume densities (Vv) of the studied structures. Results Running showed a reduction of VAT weight (-54%), triglyceride levels (-40%), Vv[islet] (-62%), Vv[islet.cells] (-22%), Vv[islet.insterstitial] (-44%), and Vv[acinar.insterstitial] (-24%) and an increase of Vv[acini] (+21%) and Vv[acinar.cells] (+22%). Regarding walking, we observed a decrease of VAT weight (-34%) and triglyceride levels (-27%), an increase of Vv[islet.cells] (+72%) and Vv[acinar.cells] (+7%), and a decrease of Vv[acini] (-4%) and Vv[acinar.insterstitial] (-16%) when compared with those in the MS group. Conclusion Our results suggest that the experimental model with low-intensity exercise (walking) seems to be more particularly recommended for preventing morphological and metabolic disorders occurring in the MS.

10 citations

Journal ArticleDOI
TL;DR: In this paper, the TL properties of synthetic β-spodumene polycrystals were investigated and some dosimetric properties of them were also discussed; however, the dopants do not affect the TL peak position with respect a pure β -spodumaene sample but the intensity of the TL peaks at 180 and 280 ∘ C is improved in the Ce-doped one.

10 citations

Journal ArticleDOI
TL;DR: In this paper, a material utilizado constou de um roteiro de entrevista com perguntas abertas, analisado segundo o metodo de Lefevre e Lefebre, tendo como amostra tres psicologos e tres psiquiatras em um ambulatorio de uma instituicao publica de saude do Estado de Sao Paulo.
Abstract: Muito se tem discutido acerca da interrelacao entre psicologos e psiquiatras quanto ao tratamento multidisciplinar de seus pacientes, e este aspecto constituiu-se no objetivo principal desta investigacao. O material utilizado constou de um roteiro de entrevista com perguntas abertas, analisado segundo o metodo de Lefevre e Lefevre, tendo como amostra tres psicologos e tres psiquiatras em um ambulatorio de uma instituicao publica de saude do Estado de Sao Paulo. As conclusoes resultantes desta pesquisa revelam ainda existirem pontos de divergencia entre as especialidades, mas sugerem perspectivas de entrosamento no que se refere ao entendimento e expectativas entre elas.

10 citations

Journal Article
TL;DR: The findings strongly suggest that previous arterial baroreflex deficiency may induce additional impairment of vagal tonus, which was associated with calcium handling proteins abnormalities, probably triggering ventricular diastolic dysfunction after MI in rats.
Abstract: Baroreflex dysfunction has been considered an important mortality predictor after myocardial infarction (MI). However, the impact of baroreflex deficiency prior to MI on tonic autonomic control and cardiac function, and on the profile of proteins associated with intracellular calcium handling has not yet been studied. The aim of the present study was to analyze how the impairment of baroreflex induced by sinoaortic denervation (SAD) prior to MI in rats affects the tonic autonomic control, ventricular function and cardiomyocyte calcium handling proteins. After 15 days of following or SAD surgery, rats underwent MI. Echocardiographic, hemodynamic, autonomic and molecular evaluations were performed 90 days after MI. Baroreflex impairment led to additional damage on: left ventricular remodeling, diastolic function, vagal tonus and intrinsic heart rate after MI. The loss of vagal component of the arterial baroreflex and vagal tonus were correlated with changes in the cardiac proteins involved in intracellular calcium homeostasis. Furthermore, additional increase in sodium calcium exchanger expression levels was associated with impaired diastolic function in experimental animals. Our findings strongly suggest that previous arterial baroreflex deficiency may induce additional impairment of vagal tonus, which was associated with calcium handling proteins abnormalities, probably triggering ventricular diastolic dysfunction after MI in rats.

10 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20228
202165
202083
201966
2018111