Institution
Universitas Kristen Indonesia
Education•Jakarta, Indonesia•
About: Universitas Kristen Indonesia is a education organization based out in Jakarta, Indonesia. It is known for research contribution in the topics: Population & Ultimate tensile strength. The organization has 685 authors who have published 728 publications receiving 2188 citations.
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23 Apr 2020
TL;DR: The study showed that the learners’ perception on online learning reveals that it is good in the midst of COVID-19 pandemic, and spotted the light on the availability of internet access, financial issue, and online learning implementation.
Abstract: The purpose of this study is to investigate the learners’ perception on online learning in the midst of a COVID-19 pandemic. This research applied qualitative method. The subject of this research are the learners of English study program of UKI Toraja. The instrument used is semi-structured interview. Thus the pandemic of covid-19, the researcher interviewed the learners by calling them by using WhatsApp application. A thematic analysis was employed in the current study. The study showed that the learners’ perception on online learning reveals that it is good in the midst of COVID-19 pandemic. They perceived online learning is very helpful in the middle of pandemic. This study not only report that online learning is good in the midst of COVID-19 pandemic but also spotted the light on the availability of internet access, financial issue, and online learning implementation. At the learners’ condition in terms of financial issue, they hope that lecturers make use of facilities such as free Messenger application in Online Learning System. In the light of the availability of internet access, they said that individual tasks are better to keep the distance physically due to pandemic, they need group tasks to help friends who do not have an internet pulse and access. About the implementation, they hope that material and assignment must be preceded by explanation. Thus, they recommended that Voice Note will be effectively used when giving instructions. It implied that the material and instruction implemented by the lecturer in the online learning were not easy to use.
161 citations
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TL;DR: PCR is more sensitive than blood culture, since some of the patients at risk for invasive yeast infection, whose blood cultures were all negative for Candida, tested positive in the PCR amplification, indicating the potential value of PCR for detecting C. albicans in serum samples and for identifying patients atrisk for invasive candidiasis.
Abstract: A rapid and sensitive PCR assay for the detection of Candida albicans DNA in serum was established. DNA from human serum samples was purified using the QIAamp blood kit, which proved to be a fast and simple method for isolating minute amounts of Candida DNA from clinical specimens for diagnosis of invasive candidiasis. Universal primer sequences used in the PCR assay are derived from the internal transcribed spacer rRNA gene of fungi, whereas the biotinylated hybridization probe used in a DNA enzyme immunoassay (DEIA) binds specifically to C. albicans DNA. The sensitivity of this PCR-DEIA method is very high; the detection limit for genomic Candida DNA is one C. albicans genome per assay. Blood from uninfected and infected persons, ranging from healthy volunteers, patients with mucocutaneous infections, and patients at risk to develop a systemic Candida infection to patients with an established systemic candidiasis, was analyzed for the presence of C. albicans to diagnose fungal infection. Candida DNA could not be detected in sera of 16 culture-negative controls and from 11 nonsystemic candidal infections by PCR or DEIA. Blood cultures from patients at risk were all negative for Candida, whereas all blood cultures from systemic candidiasis patients were positive. However, Candida DNA could be detected by PCR and DEIA in the serum from three out of nine patients who were at risk for a systemic infection and in the serum of all seven patients who had already developed an invasive Candida infection. PCR is more sensitive than blood culture, since some of the patients at risk for invasive yeast infection, whose blood cultures were all negative for Candida, tested positive in the PCR amplification. These results indicate the potential value of PCR for detecting C. albicans in serum samples and for identifying patients at risk for invasive candidiasis.
133 citations
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University of Cologne1, Cornell University2, NewYork–Presbyterian Hospital3, Federal University of Rio de Janeiro4, Collaborative Drug Discovery5, University of California, San Diego6, Innsbruck Medical University7, University of Nizwa8, University of Genoa9, Federal University of São Paulo10, Masaryk University11, Goethe University Frankfurt12, Amrita Institute of Medical Sciences and Research Centre13, Medical University of Graz14, University of Manchester15, Wayne State University16, University of Melbourne17, Peter MacCallum Cancer Centre18, Heidelberg University19, Hamad Medical Corporation20, University of Exeter21, University of Hong Kong22, University of Minnesota23, University of Hamburg24, University of Belgrade25, University of Angers26, University of Colombo27, University of Delhi28, Radboud University Nijmegen29, National and Kapodistrian University of Athens30, Palacký University, Olomouc31, Federal University of Paraná32, University of Texas Health Science Center at San Antonio33, Sheba Medical Center34, Trinity College, Dublin35, University of Toronto36, University of Indonesia37, Universitas Kristen Indonesia38
TL;DR: The One World One Guideline initiative as mentioned in this paper has been used to incorporate regional differences in the epidemiology and management of rare mold infections, including Fusarium, Lomentospora, Scedosporium, dematiaceous moulds, Rasamsonia, Schizophyllum, Scopulariopsis, Paecilomyces and Purpureocillium species.
Abstract: With increasing numbers of patients needing intensive care or who are immunosuppressed, infections caused by moulds other than Aspergillus spp or Mucorales are increasing. Although antifungal prophylaxis has shown effectiveness in preventing many invasive fungal infections, selective pressure has caused an increase of breakthrough infections caused by Fusarium, Lomentospora, and Scedosporium species, as well as by dematiaceous moulds, Rasamsonia, Schizophyllum, Scopulariopsis, Paecilomyces, Penicillium, Talaromyces and Purpureocillium species. Guidance on the complex multidisciplinary management of infections caused by these pathogens has the potential to improve prognosis. Management routes depend on the availability of diagnostic and therapeutic options. The present recommendations are part of the One World-One Guideline initiative to incorporate regional differences in the epidemiology and management of rare mould infections. Experts from 24 countries contributed their knowledge and analysed published evidence on the diagnosis and treatment of rare mould infections. This consensus document intends to provide practical guidance in clinical decision making by engaging physicians and scientists involved in various aspects of clinical management. Moreover, we identify areas of uncertainty and constraints in optimising this management.
117 citations
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Field Museum of Natural History1, University of Belgrade2, Mazandaran University of Medical Sciences3, University of Montpellier4, Duke University5, Autonomous University of Barcelona6, University of the Republic7, Post Graduate Institute of Medical Education and Research8, Wadsworth Center9, Second Military Medical University10, University of Delhi11, University of Cologne12, University of Pretoria13, Chiang Mai University14, University of Miami15, Virginia Commonwealth University16, Urmia University of Medical Sciences17, Ministry of Agriculture and Rural Development18, Federal University of Paraná19, University of Queensland20, Rovira i Virgili University21, University of Melbourne22, Kuwait University23, United States Department of Agriculture24, Katholieke Universiteit Leuven25, University of Minnesota26, University of Malawi27, University of Zimbabwe28, Liverpool School of Tropical Medicine29, Catholic University of the Sacred Heart30, University of Messina31, University of Trás-os-Montes and Alto Douro32, Meiji Pharmaceutical University33, Hamad Medical Corporation34, University of California, Berkeley35, University of Ljubljana36, Radboud University Nijmegen37, University of Indonesia38, Universitas Kristen Indonesia39, LSU Health Sciences Center New Orleans40, University of Amsterdam41
TL;DR: The advantage of recognizing these seven species is highlighted, as ignoring these species will impede deciphering further biologically and clinically relevant differences between them, which may in turn delay future clinical advances.
Abstract: Cryptococcosis is a major fungal disease caused by members of the Cryptococcus gattii and Cryptococcus neoformans species complexes. After more than 15 years of molecular genetic and phenotypic studies and much debate, a proposal for a taxonomic revision was made. The two varieties within C. neoformans were raised to species level, and the same was done for five genotypes within C. gattii. In a recent perspective (K. J. Kwon-Chung et al., mSphere 2:e00357-16, 2017, https://doi.org/10.1128/mSphere.00357-16), it was argued that this taxonomic proposal was premature and without consensus in the community. Although the authors of the perspective recognized the existence of genetic diversity, they preferred the use of the informal nomenclature "C. neoformans species complex" and "C. gattii species complex." Here we highlight the advantage of recognizing these seven species, as ignoring these species will impede deciphering further biologically and clinically relevant differences between them, which may in turn delay future clinical advances.
111 citations
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King Chulalongkorn Memorial Hospital1, Post Graduate Institute of Medical Education and Research2, Peking University3, Chang Gung University4, Singapore General Hospital5, Cebu Institute of Medicine6, Universitas Kristen Indonesia7, Sterling Hospitals8, Peking Union Medical College Hospital9, National Taiwan University10, Mahidol University11
TL;DR: There is almost no access to advanced diagnostic tests, like galactomannan, β-D-glucan, and PCR, in the surveyed laboratories in Indonesia, the Philippines, and Thailand, highlighting the need for development of quality laboratories, accreditation and training of manpower in existing laboratories, and access toAdvanced non-culture-based diagnostic tests to facilitate the diagnosis of fungal infections in Asia.
Abstract: An online survey of mycology laboratories in seven Asian countries was conducted to assess the status, competence, and services available. Country representatives from the Asia Fungal Working Group (AFWG) contacted as many laboratories performing mycology diagnosis as possible in their respective countries, requesting that the laboratory heads complete the online survey. In total, 241 laboratories responded, including 71 in China, 104 in India, 11 in Indonesia, 26 in the Philippines, four in Singapore, 18 in Taiwan, and seven in Thailand. Overall, 129/241 (53.5%) surveyed mycology laboratories operate as separate designated mycology laboratories, 75/241 (31.1%) conduct regular formal staff training, 103/241 (42.7%) are accredited, and 88/157 (56.1%) participate in external quality assurance scheme (EQAS) programs. Microscopy and culture methods are available in nearly all laboratories, although few perform DNA sequencing (37/219; 16.9%) or use matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) (27/219; 12.3%) for isolate identification. Antifungal susceptibility testing is performed in 142/241 (58.9%) laboratories, mainly for yeasts. The most commonly performed nonculture diagnostic is cryptococcal antigen testing (66 laboratories), followed by galactomannan testing (55), polymerase chain reaction (PCR) diagnosis (37), and beta-D-glucan testing (24). Therapeutic drug monitoring is conducted in 21 laboratories. There is almost no access to advanced diagnostic tests, like galactomannan, β-D-glucan, and PCR, in the surveyed laboratories in Indonesia, the Philippines, and Thailand. These results highlight the need for development of quality laboratories, accreditation and training of manpower in existing laboratories, and access to advanced non-culture-based diagnostic tests to facilitate the diagnosis of fungal infections in Asia.
72 citations
Authors
Showing all 712 results
Name | H-index | Papers | Citations |
---|---|---|---|
Sunarto Sunarto | 12 | 97 | 782 |
Lamhot Naibaho | 11 | 39 | 277 |
Retno Wahyuningsih | 9 | 28 | 482 |
Bernadetha Nadeak | 9 | 37 | 209 |
Charles O. P. Marpaung | 8 | 25 | 269 |
Elferida Sormin | 7 | 19 | 114 |
Nana Heryana | 7 | 37 | 201 |
Marina Silalahi | 7 | 59 | 290 |
Parlindungan Pardede | 6 | 17 | 151 |
Nelius Harefa | 6 | 20 | 107 |
E. Handayani Tyas | 5 | 9 | 54 |
Frenly Wehantouw | 5 | 14 | 63 |
Leony Sanga Lamsari Purba | 5 | 16 | 63 |
Citra Puspa Juwita | 5 | 11 | 70 |
Hendrikus Male | 5 | 12 | 42 |