Université catholique de Louvain

About: Université catholique de Louvain is a education organization based out in Louvain-la-Neuve, Belgium. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25319 authors who have published 57360 publications receiving 2172080 citations. The organization is also known as: University of Louvain & UCLouvain.

A new family of solvers for some classes of multidimensional partial differential equations encountered in kinetic theory modelling of complex fluids - Part II: Transient simulation using space-time separated representations

Abstract: Kinetic theory models described within the Fokker-Planck formalism involve high-dimensional spaces (including physical and conformation spaces and time). One appealing strategy for treating this kind of problems lies in the use of separated representations and tensor product approximations basis. This technique that was introduced in a former work [A. Ammar, B. Mokdad, E Chinesta, R. Keunings, A new family of solvers for some classes of multidimensional partial differential equations encountered in kinetic theory modeling of complex fluids, J. Non-Newtonian Fluid Mech. 139 (2006) 153-176] for treating steady state kinetic theory models is extended here for treating transient models. (c) 2007 Elsevier B.V. All rights reserved.

Early response to immunosuppressive therapy predicts good renal outcome in lupus nephritis: Lessons from long-term followup of patients in the Euro-Lupus Nephritis Trial

Abstract: OBJECTIVE: In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors. METHODS: Renal function was prospectively assessed quarterly in all 90 patients except 5 who were lost to followup. Survival curves were derived using the Kaplan-Meier method. RESULTS: After a median followup of 73 months, there was no significant difference in the cumulative probability of end-stage renal disease or doubling of the serum creatinine level in patients who received the low-dose IV CYC regimen versus those who received the high-dose regimen. At long-term followup, 18 patients (8 receiving low-dose and 10 receiving high-dose treatment) had developed permanent renal impairment and were classified as having poor long-term renal outcome. We demonstrated by multivariate analysis that early response to therapy at 6 months (defined as a decrease in serum creatinine level and proteinuria <1 g/24 hours) was the best predictor of good long-term renal outcome. CONCLUSION: Long-term followup of patients from the ELNT confirms that, in lupus nephritis, a remission-inducing regimen of low-dose IV CYC followed by AZA achieves clinical results comparable with those obtained with a high-dose regimen. Early response to therapy is predictive of good long-term renal outcome.

Achieving sub-second IGP convergence in large IP networks

Abstract: We describe and analyse in details the various factors that influence the convergence time of intradomain link state routing protocols. This convergence time reflects the time required by a network to react to the failure of a link or a router. To characterise the convergence process, we first use detailed measurements to determine the time required to perform the various operations of a link state protocol on currently deployed routers. We then build a simulation model based on those measurements and use it to study the convergence time in large networks. Our measurements and simulations indicate that sub-second link-state IGP convergence can be easily met on an ISP network without any compromise on stability.

Single-Column Model Intercomparison for a Stably Stratified Atmospheric Boundary Layer

Abstract: The parameterization of the stably stratified atmospheric boundary layer is a difficult issue, having a significant impact on medium-range weather forecasts and climate integrations. To pursue this further, a moderately stratified Arctic case is simulated by nineteen single-column turbulence schemes. Statistics from a large-eddy simulation intercomparison made for the same case by eleven different models are used as a guiding reference. The single-column parameterizations include research and operational schemes from major forecast and climate research centres. Results from first-order schemes, a large number of turbulence kinetic energy closures, and other models were used. There is a large spread in the results; in general, the operational schemes mix over a deeper layer than the research schemes, and the turbulence kinetic energy and other higher-order closures give results closer to the statistics obtained from the large-eddy simulations. The sensitivities of the schemes to the parameters of their turbulence closures are partially explored.