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Institution

Université catholique de Louvain

EducationLouvain-la-Neuve, Belgium
About: Université catholique de Louvain is a education organization based out in Louvain-la-Neuve, Belgium. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 25319 authors who have published 57360 publications receiving 2172080 citations. The organization is also known as: University of Louvain & UCLouvain.


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Journal ArticleDOI
01 Nov 2003-Brain
TL;DR: Findings show that the integrity of the right OFA is necessary for normal face perception and suggest that the face-sensitive responses observed at this level in normal subjects may arise from feedback connections from the right FFA.
Abstract: Neuroimaging studies have identified at least two bilateral areas of the visual extrastriate cortex that respond more to pictures of faces than objects in normal human subjects in the middle fusiform gyrus [the 'fusiform face area' (FFA)] and, more posteriorly, in the inferior occipital cortex ['occipital face area' (OFA)], with a right hemisphere dominance. However, it is not yet clear how these regions interact which each other and whether they are all necessary for normal face perception. It has been proposed that the right hemisphere FFA acts as an isolated ('modular') processing system for faces or that this region receives its face-sensitive inputs from the OFA in a feedforward hierarchical model of face processing. To test these proposals, we report a detailed neuropsychological investigation combined with a neuroimaging study of a patient presenting a deficit restricted to face perception, consecutive to bilateral occipito-temporal lesions. Due to the asymmetry of the lesions, the left middle fusiform gyrus and the right inferior occipital cortex were damaged but the right middle fusiform gyrus was structurally intact. Using functional MRI, we disclosed a normal activation of the right FFA in response to faces in the patient despite the absence of any feedforward inputs from the right OFA, located in a damaged area of cortex. Together, these findings show that the integrity of the right OFA is necessary for normal face perception and suggest that the face-sensitive responses observed at this level in normal subjects may arise from feedback connections from the right FFA. In agreement with the current literature on the anatomical basis of prosopagnosia, it is suggested that the FFA and OFA in the right hemisphere and their re-entrant integration are necessary for normal face processing.

637 citations

Journal ArticleDOI
TL;DR: In nine patients for whom a surgical specimen was available, PET was found to be the most accurate modality, however, no modality managed to depict superficial tumor extension; this was due to limitations in spatial resolution.
Abstract: PURPOSE: To compare computed tomography (CT), magnetic resonance (MR) imaging, and fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) for delineation of gross tumor volume (GTV) in pharyngolaryngeal squamous cell carcinoma and to validate results with the macroscopic surgical specimen when available. MATERIALS AND METHODS: Twenty-nine patients with stages II-IV squamous cell carcinoma treated with radiation therapy or chemotherapy and radiation therapy (n = 20) or with total laryngectomy (n = 9) were enrolled. Ten patients had oropharyngeal, 13 had laryngeal, and six had hypopharyngeal tumors. CT, MR imaging, and PET were performed with patients immobilized in a customized thermoplastic mask, and images were coregistered. GTVs obtained with the three modalities were compared quantitatively and qualitatively. If patients underwent total laryngectomy, images were validated with the surgical specimen after three-dimensional coregistration. The effect of each modality was estimated with linear mixed-effects models. Adjustments for multiple comparisons were made with the Bonferonni or Sidak method. RESULTS: For oropharyngeal tumors and for laryngeal or hypopharyngeal tumors, no significant difference (P >.99) was observed between average GTVs delineated at CT (32.0 and 21.4 cm(3), respectively) or MR imaging (27.9 and 21.4 cm(3), respectively), whereas average GTVs at PET were smaller (20.3 [P

634 citations

Journal ArticleDOI
TL;DR: It is demonstrated that expression of full-length utrophin in mdx mice prevents the development of muscular dystrophy and provides evidence that the pathology depends on the amount of utphin expression.
Abstract: Duchenne muscular dystrophy (DMD) is a lethal, progressive muscle wasting disease caused by a loss of sarcolemmal bound dystrophin, which results in the death of the muscle fiber leading to the gradual depletion of skeletal muscle. The molecular structure of dystrophin is very similar to that of the related protein utrophin. Utrophin is found in all tissues and is confined to the neuromuscular and myotendinous junctions in mature muscle. Sarcolemmal localization of a truncated utrophin transgene in the dystrophin-deficient mdx mouse significantly improves the dystrophic muscle phenotype. Therefore, up-regulation of utrophin by drug therapy is a plausible therapeutic approach in the treatment of DMD. Here we demonstrate that expression of full-length utrophin in mdx mice prevents the development of muscular dystrophy. We assessed muscle morphology, fiber regeneration and mechanical properties (force development and resistance to stretch) of mdx and transgenic mdx skeletal and diaphragm muscle. The utrophin levels required in muscle are significantly less than the normal endogenous utrophin levels seen in lung and kidney, and we provide evidence that the pathology depends on the amount of utrophin expression. These results also have important implications for DMD therapies in which utrophin replacement is achieved by delivery using exogenous vectors.

634 citations

Journal ArticleDOI
TL;DR: The mean intraabdominal pressure on admission was not an independent risk factor for mortality; however, the occurrence of intraabDominal hypertension during the intensive care unit stay was an independent outcome predictor.
Abstract: Objective: Intraabdominal hypertension is associated with significant morbidity and mortality in surgical and trauma patients. The aim of this study was to assess, in a mixed population of critically ill patients, whether intraabdominal pressure at admission was an independent predictor for mortality and to evaluate the effects of intraabdominal hypertension on organ functions. Design: Multiple-center, prospective epidemiologic study. Setting: Fourteen intensive care units in six countries. Patients: A total of 265 consecutive patients admitted for >24 hrs during the 4-wk study period. Interventions: None. Measurements and Main Results: Intraabdominal pressure was measured twice daily via the bladder. Data recorded on admission were the patient demographics with Simplified Acute Physiology Score II, Acute Physiology and Chronic Health Evaluation II score, and type of admission; during intensive care stay, Sepsis-Related Organ Failure Assessment score and intraabdominal pressure were measured daily together with fluid balance. Nonsurvivors had a significantly higher mean intraabdominal pressure on admission than survivors: 11.4 4.8 vs. 9.5 4.8 mm Hg. Independent predictors for mortality were age (odds ratio, 1.04; 95% confidence interval, 1.01‐1.06; p .003), Acute Physiology and Chronic Health Evaluation II score (odds ratio, 1.1; 95% confidence interval, 1.05‐1.15; p < .0001), type of intensive care unit admission (odds ratio, 2.5 medical vs. surgical; 95% confidence interval, 1.24‐5.16; p .01), and the presence of liver dysfunction (odds ratio, 2.5; 95% confidence interval, 1.06‐5.8; p .04). The occurrence of intraabdominal hypertension during the intensive care unit stay was also an independent predictor of mortality (relative risk, 1.85; 95% confidence interval, 1.12‐3.06; p .01). Patients with intraabdominal hypertension at admission had significantly higher Sepsis-Related Organ Failure Assessment scores during the intensive care unit stay than patients without intraabdominal hypertension. Conclusions: Intraabdominal hypertension on admission was associated with severe organ dysfunction during the intensive care unit stay. The mean intraabdominal pressure on admission was not an independent risk factor for mortality; however, the occurrence of intraabdominal hypertension during the intensive care unit stay was an independent outcome predictor. (Crit Care Med 2005; 33:315‐322)

632 citations

Journal ArticleDOI
TL;DR: A consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network forCSF biomarker research in multiple sclerosis, and focuses on CSf collection procedures, preanalytical factors, and high-quality clinical and paraclinical information.
Abstract: There is a long history of research into body fluid biomarkers in neurodegenerative and neuroinflammatory diseases. However, only a few biomarkers in CSF are being used in clinical practice. One of the most critical factors in CSF biomarker research is the inadequate powering of studies because of the lack of sufficient samples that can be obtained in single-center studies. Therefore, collaboration between investigators is needed to establish large biobanks of well-defined samples. Standardized protocols for biobanking are a prerequisite to ensure that the statistical power gained by increasing the numbers of CSF samples is not compromised by preanalytical factors. Here, a consensus report on recommendations for CSF collection and biobanking is presented, formed by the BioMS-eu network for CSF biomarker research in multiple sclerosis. We focus on CSF collection procedures, preanalytical factors, and high-quality clinical and paraclinical information. The biobanking protocols are applicable for CSF biobanks for research targeting any neurologic disease.

632 citations


Authors

Showing all 25540 results

NameH-indexPapersCitations
Robert Langer2812324326306
Pulickel M. Ajayan1761223136241
Klaus Müllen1642125140748
Giacomo Bruno1581687124368
Willem M. de Vos14867088146
David Goldstein1411301101955
Krzysztof Piotrzkowski141126999607
Andrea Giammanco135136298093
Christophe Delaere135132096742
Vincent Lemaitre134131099190
Michael Tytgat134144994133
Jian Li133286387131
Jost B. Jonas1321158166510
George Stephans132133786865
Peter Hall132164085019
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023147
2022424
20212,952
20202,969
20192,752
20182,676