Institution
Université de Montréal
Education•Montreal, Quebec, Canada•
About: Université de Montréal is a education organization based out in Montreal, Quebec, Canada. It is known for research contribution in the topics: Population & Context (language use). The organization has 45641 authors who have published 100476 publications receiving 4004007 citations. The organization is also known as: University of Montreal & UdeM.
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors explore three alternative environmental concepts used in transdisciplinary research, and outline some of the epistemological and practical problems that each one poses, paying particular attention to the increasingly popular concept of "circular economy" and contrasts it with the more commonly-used concepts of "environmental sciences" and "sustainable development".
Abstract: The intermeshing of disciplines from the natural sciences, social sciences, engineering and management has become essential to addressing today's environmental challenges. Yet, this can be a daunting task because experts from different disciplines may conceptualize the problems in very different ways and use vocabularies that may not be well understood by one another. This paper explores three alternative environmental concepts used in transdisciplinary research, and outlines some of the epistemological and practical problems that each one poses. It pays particular attention to the increasingly popular concept of “circular economy”, and contrasts it with the more commonly-used concepts of “environmental sciences” and “sustainable development”. In clarifying the nature, meaning and inter-relationship of these alternative concepts, the paper helps trans-disciplinary researchers to understand the opportunities and challenges associated with each one.
693 citations
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TL;DR: Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations that were specific to individuals withClonal HematopOiesis without hematological malignancies and were associated with alterations in DNA methylation.
Abstract: Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated by X-inactivation analysis, identified somatic TET2 mutations. Recurrence testing identified TET2 mutations in 10 out of 182 individuals with X-inactivation skewing. TET2 mutations were specific to individuals with clonal hematopoiesis without hematological malignancies and were associated with alterations in DNA methylation.
691 citations
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TL;DR: In this article, the authors explore different ways to extend a recurrent neural network (RNN) to a \textit{deep} RNN by carefully analyzing and understanding the architecture of an RNN.
Abstract: In this paper, we explore different ways to extend a recurrent neural network (RNN) to a \textit{deep} RNN. We start by arguing that the concept of depth in an RNN is not as clear as it is in feedforward neural networks. By carefully analyzing and understanding the architecture of an RNN, however, we find three points of an RNN which may be made deeper; (1) input-to-hidden function, (2) hidden-to-hidden transition and (3) hidden-to-output function. Based on this observation, we propose two novel architectures of a deep RNN which are orthogonal to an earlier attempt of stacking multiple recurrent layers to build a deep RNN (Schmidhuber, 1992; El Hihi and Bengio, 1996). We provide an alternative interpretation of these deep RNNs using a novel framework based on neural operators. The proposed deep RNNs are empirically evaluated on the tasks of polyphonic music prediction and language modeling. The experimental result supports our claim that the proposed deep RNNs benefit from the depth and outperform the conventional, shallow RNNs.
690 citations
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TL;DR: Evidence-based pharmacological treatments are available for first-line treatment of major depressive disorder and for management of inadequate response, however, given the limitations of the evidence base, pharmacological management of MDD still depends on tailoring treatments to the patient.
Abstract: Background:The Canadian Network for Mood and Anxiety Treatments (CANMAT) conducted a revision of the 2009 guidelines by updating the evidence and recommendations. The scope of the 2016 guidelines r...
689 citations
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TL;DR: The systematic characterization of phagosome proteins provided new insights intophagosome functions and the protein or groups of proteins involved in and regulating these functions.
Abstract: Phagosomes are key organelles for the innate ability of macrophages to participate in tissue remodeling, clear apoptotic cells, and restrict the spread of intracellular pathogens. To understand the functions of phagosomes, we initiated the systematic identification of their proteins. Using a proteomic approach, we identified >140 proteins associated with latex bead–containing phagosomes. Among these were hydrolases, proton pump ATPase subunits, and proteins of the fusion machinery, validating our approach. A series of unexpected proteins not previously described along the endocytic/phagocytic pathways were also identified, including the apoptotic proteins galectin3, Alix, and TRAIL, the anti-apoptotic protein 14-3-3, the lipid raft-enriched flotillin-1, the anti-microbial molecule lactadherin, and the small GTPase rab14. In addition, 24 spots from which the peptide masses could not be matched to entries in any database potentially represent new phagosomal proteins. The elaboration of a two-dimensional gel database of >160 identified spots allowed us to analyze how phagosome composition is modulated during phagolysosome biogenesis. Remarkably, during this process, hydrolases are not delivered in bulk to phagosomes, but are instead acquired sequentially. The systematic characterization of phagosome proteins provided new insights into phagosome functions and the protein or groups of proteins involved in and regulating these functions.
688 citations
Authors
Showing all 45957 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yoshua Bengio | 202 | 1033 | 420313 |
Alan C. Evans | 183 | 866 | 134642 |
Richard H. Friend | 169 | 1182 | 140032 |
Anders Björklund | 165 | 769 | 84268 |
Charles N. Serhan | 158 | 728 | 84810 |
Fernando Rivadeneira | 146 | 628 | 86582 |
C. Dallapiccola | 136 | 1717 | 101947 |
Michael J. Meaney | 136 | 604 | 81128 |
Claude Leroy | 135 | 1170 | 88604 |
Georges Azuelos | 134 | 1294 | 90690 |
Phillip Gutierrez | 133 | 1391 | 96205 |
Danny Miller | 133 | 512 | 71238 |
Henry T. Lynch | 133 | 925 | 86270 |
Stanley Nattel | 132 | 778 | 65700 |
Lucie Gauthier | 132 | 679 | 64794 |