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Institution

Université de Sherbrooke

EducationSherbrooke, Quebec, Canada
About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.


Papers
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Journal ArticleDOI
TL;DR: The study suggests that the poor specificity and the poor positive predictive value of the clinical case definition of influenza preclude its use for prediction of influenza virus infections during epidemics, especially when infection control decision making in the hospital setting is considered.
Abstract: The diagnostic performances of the clinical case definition of influenza virus infection based on the combination of fever and cough and of two rapid influenza diagnostic tests, the Directigen Flu A+B test (Directigen; BD Diagnostic Systems, Sparks, Md.) and the QuickVue influenza test (QuickVue; Quidel, San Diego, Calif.), were compared to those of viral culture and an in-house reverse transcription (RT)-PCR during the 2000-2001 flu season. Two hundred consecutive nasopharyngeal aspirates were analyzed from 192 patients, including 122 adults and 70 children. Viral culture identified influenza virus A in 16 samples and influenza virus B in 55 samples, whereas RT-PCR identified influenza virus A in 21 samples and influenza virus B in 64 samples. When RT-PCR was used as the reference standard, the likelihood ratios for a positive test were 40.0 for Directigen, 8.6 for QuickVue, and 1.4 for the combination of fever and cough, whereas the likelihood ratios for a negative test were 0.22, 0.16, and 0.48, respectively. Our study suggests that (i) the poor specificity (35 to 58%) and the poor positive predictive value (41 to 60%) of the clinical case definition of influenza preclude its use for prediction of influenza virus infections during epidemics, especially when infection control decision making in the hospital setting is considered; (ii) Directigen has a higher diagnostic yield than QuickVue but is associated with a larger number of invalid results; (iii) the sensitivities of the rapid diagnostic tests are significantly lower with samples from adults than with samples from children, with the rates of false-negative results reaching up to 29%; and (iv) RT-PCR detects more cases of influenza than viral culture, and this greater accuracy makes it a more useful reference standard.

220 citations

Journal ArticleDOI
TL;DR: Filamentous fungi Trichoderma reesei are considered to be one of the most efficient hyper producers of cellulase that is used in industry and were carried out using high concentration of cellulose to substitute glucose with the aim to improve cellulase production while trying to reduce production costs.

219 citations

Journal ArticleDOI
TL;DR: A fully integrated disability prevention model for occupational back pain appeared to be cost beneficial for the workers’ compensation board and to save more days on benefits than usual care or partial interventions.
Abstract: Methods: A randomised trial design with four arms was used: standard care, occupational arm, clini- cal arm, and Sherbrooke model arm (combined occupational and clinical interventions). From the Que- bec WCB perspective, a cost-benefit (amount of consequence of disease costs saved) and cost-effectiveness analysis (amount of dollars spent for each saved day on full benefits) were calculated for each experimental arm of the study, compared to standard care. Results: At the mean follow up of 6.4 years, all experimental study arms showed a trend towards cost benefit and cost effectiveness. These results were owing to a small number of very costly cases. The largest number of days saved from benefits was in the Sherbrooke model arm. Conclusions: A fully integrated disability prevention model for occupational back pain appeared to be cost beneficial for the workers' compensation board and to save more days on benefits than usual care or partial interventions. A limited number of cases were responsible for most of the long term dis- ability costs, in accordance with occupational back pain epidemiology. However, further studies with larger samples will be necessary to confirm these results.

219 citations

Journal ArticleDOI
TL;DR: It is proposed that cyclic dinucleotides like c-di-GMP can be used clinically in humans and animals as an immunomodulator, immune enhancer, immunotherapeutic, immunoprophylactic, or vaccine adjuvant.
Abstract: Cyclic diguanylate (c-di-GMP) is a bacterial intracellular signaling molecule. We have shown that treatment with exogenous c-di-GMP inhibits Staphylococcus aureus infection in a mouse model. We now report that c-di-GMP is an immodulator and immunostimulatory molecule. Intramammary treatment of mice with c-di-GMP 12 and 6 h before S. aureus challenge gave a protective effect and a 10,000-fold reduction in CFUs in tissues ( p S. aureus clumping factor A (ClfA) Ag produced serum with significantly higher anti-ClfA IgG Ab titers ( p

219 citations

Journal ArticleDOI
TL;DR: Mass spectrometry analysis showed that the enzymatic treatment produced high molecular weight metabolites through a radical polymerization mechanism of NP, BPA and TCS, and these oligomers were produced through the formation of C-C or C-O bonds.

219 citations


Authors

Showing all 15051 results

NameH-indexPapersCitations
Masashi Yanagisawa13052483631
Joseph V. Bonventre12659661009
Jeffrey L. Benovic9926430041
Alessio Fasano9647834580
Graham Pawelec8957227373
Simon C. Robson8855229808
Paul B. Corkum8857637200
Mario Leclerc8837435961
Stephen M. Collins8632025646
Ed Harlow8619061008
William D. Fraser8582730155
Jean Cadet8337224000
Vincent Giguère8222727481
Robert Gurny8139628391
Jean-Michel Gaillard8141026780
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202384
2022189
20211,858
20201,805
20191,625
20181,543