Université de Sherbrooke

About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.

Double-blind, randomized trial of an anti-CD18 antibody in conjunction with recombinant tissue plasminogen activator for acute myocardial infarction: limitation of myocardial infarction following thrombolysis in acute myocardial infarction (LIMIT AMI) study.

Abstract: Background Inhibition of leukocyte adhesion can reduce myocardial infarct size in animals. This study was designed to define the safety and efficacy of a recombinant, humanized, monoclonal antibody to the CD18 subunit of the β2 integrin adhesion receptors (rhuMAb CD18), in reducing infarct size in patients treated with a thrombolytic agent. Methods and Results The Limitation of Myocardial Infarction following Thrombolysis in Acute Myocardial Infarction Study (LIMIT AMI) was a randomized, double-blind, placebo-controlled, multicenter study conducted in 60 centers in the United States and Canada. A total of 394 subjects who presented within 12 hours of symptom onset with ECG findings (ST-segment elevation) consistent with AMI were treated with recombinant tissue plasminogen activator and were also given an intravenous bolus of 0.5 or 2.0 mg/kg rhuMAb CD18 or placebo. Coronary angiography was performed at 90 minutes, 12-lead ECGs were obtained at baseline, 90, and 180 minutes, and resting sestamibi scans were performed at ≥120 hours. Adjunctive angioplasty and use of glycoprotein IIb/IIIa antiplatelet agents at the time of angiography were discretionary. There were no treatment effects on coronary blood flow, infarct size, or the rate of ECG ST-segment elevation resolution, despite the expected induction of peripheral leukocytosis. A slight trend toward an increase in bacterial infections was observed with rhuMAb CD18 ( P =0.33). Conclusions RhuMAb CD18 was well tolerated but not effective in modifying cardiac end points. Received February 28, 2001; revision received September 25, 2001; accepted September 28, 2001.

Axial Capacity of Circular Concrete Columns Reinforced with GFRP Bars and Spirals

Abstract: Several codes and design guidelines are now available for the design of concrete structures reinforced with fiber-reinforced polymer (FRP) bars under flexural and shear loads. Yet, because of a lack of research, North American codes and design guidelines do not recommend using FRP bars as longitudinal reinforcement in columns to resist compressive stresses. This paper reports on 12 full-scale circular reinforced concrete (RC) columns that were tested under concentric axial loads. The columns were reinforced with longitudinal glass FRP (GFRP) bars and newly developed GFRP spirals. The 300-mm diameter columns were designed according to code requirements. The test parameters included reinforcement type (GFRP versus steel); longitudinal FRP reinforcement ratio; and the volumetric ratios, diameters, and spacing of spiral reinforcement. The test results indicated that the GFRP and steel RC columns behaved in a similar manner. The average load carried by the longitudinal GFRP bars ranged between 5% and 1...

Co-variations in litter decomposition, leaf traits and plant growth in species from a Mediterranean old-field succession

Abstract: Summary 1A growing consensus is developing that the impact of species on ecosystem properties is mediated, at least partially, by the traits of their component species. A previous study demonstrated that the field decomposition of complex litters produced by different communities of a Mediterranean successional sere was related to the average trait value of these communities. Here we scale down to the species level, to test whether similar relationships are found for selected species from these communities. We also test whether litter decomposability can be considered as part of the suite of traits characterizing the fast–slow growth continuum in plants. 2We chose 12 of the most abundant herbaceous species characteristics of three stages of the old-field succession mentioned above. We investigated trait variation and covariation for the eight following traits: specific leaf area (SLA), leaf phosphorus (LPC), nitrogen (LNC) and carbon (LCC) concentrations, leaf dry matter content (LDMC) and leaf total phenols (TPh), all on material collected in the field; and litter decomposability (Kpot) and maximum relative growth rate (RGRmax), obtained under standardized conditions in the laboratory. 3Five of these traits were significantly lower in species from the advanced successional stage. These trends were similar when comparisons were conducted either with the 12 species, or on a subset incorporating taxonomic information. LDMC was the single trait best correlated with species RGRmax and Kpot; the two latter traits were also significantly correlated with one another. 4These results provide clear evidence of functional links between plant growth, leaf traits and litter decomposability. LDMC appears as a pivotal trait of living leaves related to their structural properties. It influences the quality of the litter produced, and hence species’ potential ‘after-life effects’ on ecosystem properties.