Université de Sherbrooke

About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.

Risk factors for recurrent venous thromboembolism in the European collaborative paediatric database on cerebral venous thrombosis: a multicentre cohort study

Abstract: Summary Background The relative importance of previous diagnosis and hereditary prothrombotic risk factors for cerebral venous thrombosis (CVT) in children in determining risk of a second cerebral or systemic venous thrombosis (VT), compared with other clinical, neuroimaging, and treatment variables, is unknown. Methods We followed up the survivors of 396 consecutively enrolled patients with CVT, aged newborn to 18 years (median 5·2 years) for a median of 36 months (maximum 85 months). In accordance with international treatment guidelines, 250 children (65%) received acute anticoagulation with unfractionated heparin or low-molecular weight heparin, followed by secondary anticoagulation prophylaxis with low-molecular weight heparin or warfarin in 165 (43%). Results Of 396 children enrolled, 12 died immediately and 22 (6%) had recurrent VT (13 cerebral; 3%) at a median of 6 months (range 0·1–85). Repeat venous imaging was available in 266 children. Recurrent VT only occurred in children whose first CVT was diagnosed after age 2 years; the underlying medical condition had no effect. In Cox regression analyses, non-administration of anticoagulant before relapse (hazard ratio [HR] 11·2 95% CI 3·4–37·0; p Conclusion Age at CVT onset, non-administration of anticoagulation, persistent venous occlusion, and presence of G20210A mutation in factor II predict recurrent VT in children. Secondary prophylactic anticoagulation should be given on a patient-to-patient basis in children with newly identified CVT and at high risk of recurrent VT. Factors that affect recanalisation need further research.

Electron-nuclear dynamics of multiphoton H 2 + dissociative ionization in intense laser fields

Abstract: The time-dependent Schr\"odinger equation for the one-dimensional ${\mathrm{H}}_{2}^{+}$ molecule (with both nuclear and electronic degrees of freedom included) was solved numerically to study dissociative ionization. A wave-function splitting technique was used with projections onto Volkov states, which allows one to circumvent the problem of lost information on electron flux due to absorbing boundary methods. This technique allows us to calculate the above-threshold ionization (ATI) photo electron kinetic-energy spectra in the presence of moving nuclei, as well as complete spectra of dissociating protons, beyond the Born-Oppenheimer approximation. The ATI spectra are considerably enhanced with respect to the H-atom spectra due to electron molecule interaction. The peaks seen in calculated Coulomb explosion spectra of protons agree well with recent theoretical and experimental work related to the phenomenon of charge-resonance-enhanced ionization in molecules.

Photoresponsive Nanogels Based on Photocontrollable Cross-Links

Abstract: We present a new and general strategy for preparing photoresponsive nanogels. It is based on using light to reversibly change the cross-linking density of nanogel particles to control their swelling degree in aqueous solution. This control mechanism allows for gradual volume change of nanogel particles by light. For proof of concept, diblock copolymers composed of poly(ethylene oxide) and poly[2-(2-methoxyethoxy)ethyl methacrylate-co-4-methyl-[7-(methacryloyl)oxyethyloxy]coumarin] (PEO-b-P(MEOMA-co-CMA)) were synthesized; nanogels could easily be prepared by first photo-cross-linking the micellar aggregates at T > LCST of the P(MEOMA-co-CMA) block through dimerization of coumarin side groups upon absorption of λ > 310 nm UV light and then cooling the solution to T < LCST to obtain cross-linked water-soluble polymer nanoparticles. Under λ < 260 nm UV light, the reverse photocleavage of cyclobutane rings could be used to reduce the cross-linking density, leading to the swelling of nanogel particles with a v...

Scattering and Pairing in Cuprate Superconductors

Abstract: The origin of the exceptionally strong superconductivity of cuprates remains a subject of debate after more than two decades of investigation. Here we follow a new lead: The onset temperature for superconductivity scales with the strength of the anomalous normal-state scattering that makes the resistivity linear in temperature. The same correlation between linear resistivity and Tc is found in organic superconductors, for which pairing is known to come from fluctuations of a nearby antiferromagnetic phase, and in pnictide superconductors, for which an antiferromagnetic scenario is also likely. In the cuprates, the question is whether the pseudogap phase plays the corresponding role, with its fluctuations responsible for pairing and scattering. We review recent studies that shed light on this phase - its boundary, its quantum critical point, and its broken symmetries. The emerging picture is that of a phase with spin-density-wave order and fluctuations, in broad analogy with organic, pnictide, and heavy-fermion superconductors.

Lipid-induced pancreatic β-cell dysfunction: focus on in vivo studies

Abstract: The phenomenon of lipid-induced pancreatic β-cell dysfunction (“lipotoxicity”) has been very well documented in numerous in vitro experimental systems and has become widely accepted. In vivo demons...