Institution
Université de Sherbrooke
Education•Sherbrooke, Quebec, Canada•
About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.
Topics: Population, Receptor, Health care, Angiotensin II, Poison control
Papers published on a yearly basis
Papers
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TL;DR: It is demonstrated herein that the levels of fur mRNA, encoding furin, are remarkably increased upon hypoxic challenge, and a new facet of the physiological consequences of hypoxia/HIF-1 is unveiled, through enhanced furin-induced proteolytic processing/activation of proproteins known to be involved in tumorigenesis.
163 citations
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TL;DR: There is compelling evidence for a novel intracrine mode of genomic regulation by GPCRs that implies either the endocytosis and nuclear translocation of peripheral-liganded G PCR and (or) the activation of nuclearly located GPCR by endogenously produced, nonsecreted ligands.
Abstract: G-protein-coupled receptors (GPCRs) comprise a wide family of monomeric heptahelical glycoproteins that recognize a broad array of extracellular mediators including cationic amines, lipids, peptide...
163 citations
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TL;DR: Roball, a ball-shaped robot that moves by making its external spherical shell rotate shows robustness in handling unstructured environments and unconstrained interactions with children.
Abstract: Designing a mobile robotic toy is challenging work The robot must be appealing to children and create interesting interactions while facing the wide variety of situations that can be experienced while playing with a child, and all at a reasonable cost In this paper we present Roball, a ball-shaped robot that moves by making its external spherical shell rotate Such design for a mobile robotic toy shows robustness in handling unstructured environments and unconstrained interactions with children Results show that purposeful movements of the robot, its physical structure and locomotion dynamics generate interesting new games influenced by the environment and the child
163 citations
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TL;DR: A phylogenetically controlled meta-analysis of 357 effect sizes across 88 different species of birds suggests complementary mechanisms maintaining honesty rather than the involvement of carotenoids in immune function and oxidative stress and suggestions on how to test these.
Abstract: Mechanisms maintaining honesty of sexual signals are far from resolved, limiting our understanding of sexual selection and potential important parts of physiology. Carotenoid pigmented visual signals are among the most extensively studied sexual displays, but evidence regarding hypotheses on how carotenoids ensure signal honesty is mixed. Using a phylogenetically controlled meta-analysis of 357 effect sizes across 88 different species of birds, we tested two prominent hypotheses in the field: that carotenoid-dependent coloration signals i) immunocompetence and/or ii) oxidative stress state. Separate meta-analyses were performed for the relationships of trait coloration and circulating carotenoid level with different measures of immunocompetence and oxidative stress state. For immunocompetence we find that carotenoid levels (r = 0.20) and trait color intensity (r = 0.17) are significantly positively related to PHA response. Additionally we find that carotenoids are significantly positively related to antioxidant capacity (r = 0.10), but not significantly related to oxidative damage (r = -0.02). Thus our analyses provide support for both hypotheses, in that at least for some aspects of immunity and oxidative stress state the predicted correlations were found. Furthermore, we tested for differences in effect size between experimental and observational studies; a larger effect in observational studies would indicate that co-variation might not be causal. However, we detected no significant difference, suggesting that the relationships we found are causal. The overall effect sizes we report are modest and we discuss potential factors contributing to this, including differences between species. We suggest complementary mechanisms maintaining honesty rather than the involvement of carotenoids in immune function and oxidative stress and suggest experiments on how to test these.
163 citations
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TL;DR: The retrospective matrix method provides a good approximation of the demographic rate associated most strongly with variation in population growth, however, failure to incorporate the contribution of covariation between demographic rates when decomposing variation inpopulation growth can lead to spurious conclusions.
Abstract: Summary
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The decomposition of variation in population growth into the relative contributions from different demographic rates has multiple uses in population, conservation and evolutionary biology Recent research has favoured methods based on matrix models termed ‘life-table-response experiments’ or more generally ‘the retrospective matrix method’, which provide an approximation of a complete demographic decomposition The performance of the approximation has not been assessed
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We compare the performance of the retrospective matrix method to a complete decomposition for two bighorn sheep populations and one red deer population
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Different demographic rates make markedly different contributions to variation in growth rate between populations, because each population is subject to different types of environmental variation
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The most influential demographic rates identified from decomposing observed variation in population growth are often not those showing the highest elasticity Consequently, those demographic rates most strongly associated with deterministic population growth are not necessarily strongly associated with temporal variation in population growth
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The retrospective matrix method provides a good approximation of the demographic rate associated most strongly with variation in population growth However, failure to incorporate the contribution of covariation between demographic rates when decomposing variation in population growth can lead to spurious conclusions
163 citations
Authors
Showing all 15051 results
Name | H-index | Papers | Citations |
---|---|---|---|
Masashi Yanagisawa | 130 | 524 | 83631 |
Joseph V. Bonventre | 126 | 596 | 61009 |
Jeffrey L. Benovic | 99 | 264 | 30041 |
Alessio Fasano | 96 | 478 | 34580 |
Graham Pawelec | 89 | 572 | 27373 |
Simon C. Robson | 88 | 552 | 29808 |
Paul B. Corkum | 88 | 576 | 37200 |
Mario Leclerc | 88 | 374 | 35961 |
Stephen M. Collins | 86 | 320 | 25646 |
Ed Harlow | 86 | 190 | 61008 |
William D. Fraser | 85 | 827 | 30155 |
Jean Cadet | 83 | 372 | 24000 |
Vincent Giguère | 82 | 227 | 27481 |
Robert Gurny | 81 | 396 | 28391 |
Jean-Michel Gaillard | 81 | 410 | 26780 |