Institution
Université de Sherbrooke
Education•Sherbrooke, Quebec, Canada•
About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.
Topics: Population, Receptor, Health care, Angiotensin II, Poison control
Papers published on a yearly basis
Papers
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TL;DR: Biochemical analyses performed on irradiated cells suggest that the cytoplasmic membrane is an important target of the photoprocess, while DNA is not involved.
Abstract: Escherichia coli, as most Gram-negative bacteria, is insensitive to the photosensitizing action of both lipid-soluble Zinc-phthalocyanine (Zn-Pc) and water-soluble Zinc-mono/disulfonated phthalocyanine (Zn-PcS). Photosensitivity can be induced by alteration of the outer membrane, as obtained by either induction of competence or treatment with Tris-EDTA. Both phthalocyanines largely bind at the level of the cytoplasmic membrane; however, Zn-PcS shows a superior photosensitizing activity as compared with Zn-Pc. Biochemical analyses performed on irradiated cells suggest that the cytoplasmic membrane is an important target of the photoprocess, while DNA is not involved.
162 citations
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TL;DR: In this article, a review of boundary-layer parameters characterizing the pressure gradient effects is provided, and the more relevant ones are introduced as new variables in the model and compared to the zero pressure gradient model it is derived from.
Abstract: 4, in both internal (channel) and external (airfoil) flows. A review of the boundary-layer parameters characterizing the pressure gradient effects is provided, and the more relevant ones are introduced as new variables in the model. The method is then compared to the zero pressure gradient model it is derived from. The influence of the pressure gradient on the wall-pressure spectrum is discussed.Finally,themethodisappliedtoprovideinputdataofaradiatedtrailing-edge noisemodelbymeansofan aeroacoustic analogy, namely Amiet’s theory of turbulent boundary layer past a trailing edge. The results are compared to experimental data obtained in an open-jet anechoic wind tunnel.
162 citations
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TL;DR: It is demonstrated that, beyond the obvious difference in transcriptional and translational modulation, both adenine riboswitches exhibit different ligand binding properties and appear to operate under different regulation regimes (kinetic versus thermodynamic).
Abstract: Many bacterial mRNAs are regulated at the transcriptional or translational level by ligand-binding elements called riboswitches Although they both bind adenine, the adenine riboswitches of Bacillus subtilis and Vibrio vulnificus differ by controlling transcription and translation, respectively Here, we demonstrate that, beyond the obvious difference in transcriptional and translational modulation, both adenine riboswitches exhibit different ligand binding properties and appear to operate under different regulation regimes (kinetic versus thermodynamic) While the B subtilis pbuE riboswitch fully depends on co-transcriptional binding of adenine to function, the V vulnificus add riboswitch can bind to adenine after transcription is completed and still perform translation regulation Further investigation demonstrates that the rate of transcription is critical for the B subtilis pbuE riboswitch to perform efficiently, which is in agreement with a co-transcriptional regulation Our results suggest that the nature of gene regulation control, that is transcription or translation, may have a high importance in riboswitch regulatory mechanisms
162 citations
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TL;DR: The magnitude of flicker noise, considered as resistance fluctuations, in random resistor networks are reported and the new exponent $\ensuremath{\kappa}$ is calculated by various methods: Monte Carlo simulations, effective-medium theory, and position-space renormalization group.
Abstract: New results for the magnitude of flicker noise, considered as resistance fluctuations, in random resistor networks are reported. Near the percolation threshold ${p}_{c}$, the magnitude of the relative noise is shown to diverge as ${(p\ensuremath{-}{p}_{c})}^{\ensuremath{-}\ensuremath{\kappa}}$. The new exponent $\ensuremath{\kappa}$ is calculated by various methods: Monte Carlo simulations, effective-medium theory, and position-space renormalization group. Exponents pertaining to higher-order cumulants of the resistance fluctuations are also calculated. The possible implications of our results for ongoing experiments on metal-insulator mixtures and cermets are also discussed.
162 citations
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TL;DR: Comparison of sequences of multiple paralogous rRNA genes within a genome in 12 prokaryotic organisms that have multiple copies of the r RNA genes shows that gene conversion underlies concerted evolution of bacterial rRN genes, which normally occurs within genic sequences, and homogenization of flanking regions may result from co-conversion with the genic sequence.
Abstract: Multiple copies of a given ribosomal RNA gene family undergo concerted evolution such that sequences of all gene copies are virtually identical within a species although they diverge normally between species. In eukaryotes, gene conversion and unequal crossing over are the proposed mechanisms for concerted evolution of tandemly repeated sequences, whereas dispersed genes are homogenized by gene conversion. However, the homogenization mechanisms for multiple-copy, normally dispersed, prokaryotic rRNA genes are not well understood. Here we compared the sequences of multiple paralogous rRNA genes within a genome in 12 prokaryotic organisms that have multiple copies of the rRNA genes. Within a genome, putative sequence conversion tracts were found throughout the entire length of each individual rRNA genes and their immediate flanks. Individual conversion events convert only a short sequence tract, and the conversion partners can be any paralogous genes within the genome. Interestingly, the genic sequences undergo much slower divergence than their flanking sequences. Moreover, genomic context and operon organization do not affect rRNA gene homogenization. Thus, gene conversion underlies concerted evolution of bacterial rRNA genes, which normally occurs within genic sequences, and homogenization of flanking regions may result from co-conversion with the genic sequence.
162 citations
Authors
Showing all 15051 results
Name | H-index | Papers | Citations |
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Masashi Yanagisawa | 130 | 524 | 83631 |
Joseph V. Bonventre | 126 | 596 | 61009 |
Jeffrey L. Benovic | 99 | 264 | 30041 |
Alessio Fasano | 96 | 478 | 34580 |
Graham Pawelec | 89 | 572 | 27373 |
Simon C. Robson | 88 | 552 | 29808 |
Paul B. Corkum | 88 | 576 | 37200 |
Mario Leclerc | 88 | 374 | 35961 |
Stephen M. Collins | 86 | 320 | 25646 |
Ed Harlow | 86 | 190 | 61008 |
William D. Fraser | 85 | 827 | 30155 |
Jean Cadet | 83 | 372 | 24000 |
Vincent Giguère | 82 | 227 | 27481 |
Robert Gurny | 81 | 396 | 28391 |
Jean-Michel Gaillard | 81 | 410 | 26780 |