Université de Sherbrooke

About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.

Laboratory assessment and durability performance of vinyl-ester, polyester, and epoxy glass-FRP bars for concrete structures

Abstract: In the last decade, noncorrosive glass fiber-reinforced-polymer (GFRP) bars have become more widely accepted as cost-effective alternatives to steel bars in many applications for concrete structures (bridges, parking garages, and water tanks). Also, these reinforcing bars are valuable for temporary concrete structures such as soft-eyes in tunneling works. The cost of the GFRP bars can be optimized considering the type of resin according the application. Yet limited research seems to have investigated the durability of GFRP bars manufactured with different types of resin. In this study, the physical and mechanical properties of GFRP bars made with vinyl-ester, isophthalic polyester, or epoxy resins were evaluated first. The long-term performance of these bars under alkaline exposure simulating a concrete environment was then assessed in accordance with ASTM D7705 . The alkaline exposure consisted in immersing the bars in an alkaline solution for 1000, 3000 and 5000 h at elevated temperature (60 °C) to accelerate the effects. Subsequently, the bar properties were assessed and compared with the values obtained on unconditioned reference specimens. The test results reveal that the vinyl-ester and epoxy GFRP bars had the best physical and mechanical properties and lowest degradation rate after conditioning in alkaline solution, while the polyester GFRP bars evidenced the lowest physical and mechanical properties and exhibited significant degradation of physical and mechanical properties after conditioning.

Commentary: polycystic ovary syndrome: a syndrome of ovarian hypersensitivity to insulin?

Abstract: Polycystic ovary syndrome (PCOS) affects 6–10% of women of child-bearing age (1). It is defined by hyperandrogenism, chronic anovulation, and/or polycystic ovaries (two of three criteria); after exclusion of secondary causes (2). However, it has become apparent that insulin resistance and hyperinsulinemia play a critical role in the syndrome’s pathogenesis (1). Despite advances over the past decade, many questions remain regarding both the nature of insulin resistance in PCOS and the mechanism by which insulin resistance or insulin produces hyperandrogenemia.

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

Abstract: Background MUC16 is a cell surface mucin expressed at high levels by epithelial ovarian tumors. Following proteolytic cleavage, cell surface MUC16 (csMUC16) is shed in the extracellular milieu and is detected in the serum of cancer patients as the tumor marker CA125. csMUC16 acts as an adhesion molecule and facilitates peritoneal metastasis of ovarian tumors. Both sMUC16 and csMUC16 also protect cancer cells from cytotoxic responses of natural killer (NK) cells. In a previous study we demonstrated that sMUC16 binds to specific subset of NK cells. Here, we identify the csMUC16/sMUC16 binding partner expressed on immune cells.

Early Patient Screening and Intervention to Address Individual-Level Occupational Factors (“Blue Flags”) in Back Disability

Abstract: Objective To develop a consensus plan for research and practice to encourage routine clinician screening of occupational factors associated with long-term back disability. Methods A 3-day conference workshop including 21 leading researchers and clinicians (the “Decade of the Flags Working Group”) was held to review the scientific evidence concerning clinical, occupational, and policy factors in back disability and the development of feasible assessment and intervention strategies. Results The Working Group identified seven workplace variables to include in early screening by clinicians: physical job demands, ability to modify work, job stress, workplace social support or dysfunction, job satisfaction, expectation for resuming work, and fear of re-injury. Five evaluation criteria for screening methods were established: reliability, predictive performance, feasibility, acceptability, and congruence with plausible interventions. An optimal screening method might include a stepped combination of questionnaire, interview, and worksite visit. Future research directions include improving available assessment methods, adopting simpler and more uniform conceptual frameworks, and tying screening results to plausible interventions. Discussion There is a clear indication that occupational factors influence back disability, but to expand clinician practices in this area will require that patient screening methods show greater conceptual clarity, feasibility, and linkages to viable options for intervention.

A Comprehensive Survey of Cationic Iridium(III) Complexes Bearing Nontraditional Ligand Chelation Motifs

Abstract: The useful optoelectronic properties of cationic iridium(III) complexes have been exploited in diverse applications, from visual displays to biological probes to analytical sensors. It is thus not surprising to note the increased recent efforts to document, understand, and ultimately control the photophysical and electrochemical properties of the archetypal cationic iridium(III) complex [(ppy)2Ir(bpy)]+, in which ppyH = 2-phenylpyridine and bpy = 2,2′-bipyridine, and decorated versions thereof. Of the ligand architectures explored, the greatest attention has been devoted to ligands that incorporate the common pyridine unit. In this Microreview, we survey the salient emission and electrochemical properties of cationic iridium(III) complexes of the form [(C∧N)2Ir(L∧X)]+, in which C∧N is a cyclometalating ligand and L∧X is a bidentate neutral ancillary ligand, with at least one heterocyclic ligand other than pyridine. We contrast their properties to that of [(ppy)2Ir(bpy)]+ and highlight recent exploits in materials applications.