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Institution

Université de Sherbrooke

EducationSherbrooke, Quebec, Canada
About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.


Papers
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Journal ArticleDOI
TL;DR: The different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles are discussed.
Abstract: The association state of light-responsive block copolymer (BCP) micelles in aqueous solution can be altered, often reversibly, by light. Driven by the potential application in controlled drug delivery, this type of stimuli-responsive polymer micelles has received increasing attention. This Perspective highlights the progress achieved in recent years. On the one hand, we discuss the different approaches of rational BCP design, making use of various photochromic moieties and photochemical reactions, and the underlying mechanisms leading to photoinduced disruption of BCP micelles. On the other hand, we suggest possible future directions in this area, including exploration of new mechanisms and chemistry and solutions to the excitation wavelength problem crucial for biomedical applications.

462 citations

Journal ArticleDOI
TL;DR: Several examples of type I and type II photosensitized oxidation reactions are provided to illustrate the complexity and the diversity of the degradation pathways of mostly relevant biomolecules upon one‐electron oxidation and singlet oxygen reactions.
Abstract: Here, 10 guidelines are presented for a standardized definition of type I and type II photosensitized oxidation reactions. Because of varied notions of reactions mediated by photosensitizers, a checklist of recommendations is provided for their definitions. Type I and type II photoreactions are oxygen-dependent and involve unstable species such as the initial formation of radical cation or neutral radicals from the substrates and/or singlet oxygen (1 O21 ∆g ) by energy transfer to molecular oxygen. In addition, superoxide anion radical (O2·-) can be generated by a charge-transfer reaction involving O2 or more likely indirectly as the result of O2 -mediated oxidation of the radical anion of type I photosensitizers. In subsequent reactions, O2·- may add and/or reduce a few highly oxidizing radicals that arise from the deprotonation of the radical cations of key biological targets. O2·- can also undergo dismutation into H2 O2 , the precursor of the highly reactive hydroxyl radical (·OH) that may induce delayed oxidation reactions in cells. In the second part, several examples of type I and type II photosensitized oxidation reactions are provided to illustrate the complexity and the diversity of the degradation pathways of mostly relevant biomolecules upon one-electron oxidation and singlet oxygen reactions.

461 citations

Journal ArticleDOI
TL;DR: In this review the formation of 11 single base lesions that is accounted for by reactions of singlet oxygen, hydroxyl radical or high intensity UVC laser pulses with nucleobases is discussed on the basis of the mechanisms available from model studies.

460 citations

Journal ArticleDOI
15 Dec 1997-Spine
TL;DR: Close association of occupational intervention with clinical care is of primary importance in impeding progression toward chronicity of low back pain.
Abstract: STUDY DESIGN Population-based randomized clinical trial. OBJECTIVES To develop and test a model of management of subacute back pain, to prevent prolonged disability. SUMMARY OF BACKGROUND DATA The present management of back pain seems inadequate, and development of innovative models has been urged. METHODS A model for the treatment of subacute work-related back pain has been developed and evaluated in a population-based randomized clinical trial. Workers (n = 130) from eligible workplaces in the Sherbrooke area (N = 31), who had been absent from work for more than 4 weeks for back pain, were randomized, based on their workplace, in one of four treatment groups: usual care, clinical intervention, occupational intervention, and full intervention (a combination of the last two). The duration of absence from regular work and from any work was evaluated using survival analysis. Functional status and pain were compared at study entry and after 1 year of follow-up. RESULTS The full intervention group returned to regular work 2.41 times faster than the usual care intervention group (95% confidence interval 1.19-4.89; P < 0.01). The specific effect of the occupational intervention accounted for the most important part of this result, with a rate ratio of return to regular work of 1.91 (95% confidence interval = 1.18-3.10; P < 0.01). Pain and disability scales demonstrated either a statistically significant reduction or a trend toward reduction in the three intervention groups, compared with the trend in the usual care intervention group. CONCLUSIONS Close association of occupational intervention with clinical care is of primary importance in impeding progression toward chronicity of low back pain.

460 citations

Journal ArticleDOI
TL;DR: The data suggest that the incorporation of H2A.Z into specific promoter-bound nucleosomes configures chromatin structure to poise genes for transcriptional activation, and the relevance of these findings to higher eukaryotes is discussed.
Abstract: H2A.Z is an evolutionary conserved histone variant involved in transcriptional regulation, antisilencing, silencing, and genome stability. The mechanism(s) by which H2A.Z regulates these various biological functions remains poorly defined, in part due to the lack of knowledge regarding its physical location along chromosomes and the bearing it has in regulating chromatin structure. Here we mapped H2A.Z across the yeast genome at an approximately 300-bp resolution, using chromatin immunoprecipitation combined with tiling microarrays. We have identified 4,862 small regions—typically one or two nucleosomes wide—decorated with H2A.Z. Those “Z loci” are predominantly found within specific nucleosomes in the promoter of inactive genes all across the genome. Furthermore, we have shown that H2A.Z can regulate nucleosome positioning at the GAL1 promoter. Within HZAD domains, the regions where H2A.Z shows an antisilencing function, H2A.Z is localized in a wider pattern, suggesting that the variant histone regulates a silencing and transcriptional activation via different mechanisms. Our data suggest that the incorporation of H2A.Z into specific promoter-bound nucleosomes configures chromatin structure to poise genes for transcriptional activation. The relevance of these findings to higher eukaryotes is discussed.

460 citations


Authors

Showing all 15051 results

NameH-indexPapersCitations
Masashi Yanagisawa13052483631
Joseph V. Bonventre12659661009
Jeffrey L. Benovic9926430041
Alessio Fasano9647834580
Graham Pawelec8957227373
Simon C. Robson8855229808
Paul B. Corkum8857637200
Mario Leclerc8837435961
Stephen M. Collins8632025646
Ed Harlow8619061008
William D. Fraser8582730155
Jean Cadet8337224000
Vincent Giguère8222727481
Robert Gurny8139628391
Jean-Michel Gaillard8141026780
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202384
2022189
20211,858
20201,805
20191,625
20181,543