Institution
Université de Sherbrooke
Education•Sherbrooke, Quebec, Canada•
About: Université de Sherbrooke is a education organization based out in Sherbrooke, Quebec, Canada. It is known for research contribution in the topics: Population & Receptor. The organization has 14922 authors who have published 28783 publications receiving 792511 citations. The organization is also known as: Universite de Sherbrooke & Sherbrooke University.
Topics: Population, Receptor, Health care, Angiotensin II, Poison control
Papers published on a yearly basis
Papers
More filters
••
University of California, Los Angeles1, King's College London2, University of Florida3, Washington University in St. Louis4, Abbott Northwestern Hospital5, University of Michigan6, University of Kansas7, Columbia University Medical Center8, Indiana University9, Overlook Medical Center10, University of Rochester Medical Center11, Rush University Medical Center12, Rutgers University13, University of Cincinnati14, Hackensack University Medical Center15, University of California, Irvine16, Winthrop-University Hospital17, Rhode Island Hospital18, University of Colorado Hospital19, Henry Ford Health System20, University of Texas Health Science Center at San Antonio21, University of Pennsylvania22, University of North Carolina at Chapel Hill23, City of Hope National Medical Center24, Thomas Jefferson University25, St. Joseph Hospital26, Vanderbilt University27, Beth Israel Deaconess Medical Center28, Baylor University Medical Center29, Medical University of South Carolina30, Mount Sinai Hospital31, Dresden University of Technology32, Tufts University33, Stony Brook University34, Université de Sherbrooke35, University of California, San Diego36, Houston Methodist Hospital37, Geisinger Health System38, Kaiser Permanente39, University of Kentucky40, Montreal Neurological Institute and Hospital41, Hofstra University42, University of Washington43, Northwest Biotherapeutics44
TL;DR: Addition of DCVax-L to standard therapy is feasible and safe in glioblastoma patients, and may extend survival, and overall adverse events withDCVax were comparable to standard Therapy alone.
Abstract: Following publication of the original article [1], the authors reported an error in the spelling of one of the author names. In this Correction the incorrect and correct author names are indicated and the author name has been updated in the original publication. The authors also reported an error in the Methods section of the original article. In this Correction the incorrect and correct versions of the affected sentence are indicated. The original article has not been updated with regards to the error in the Methods section.
355 citations
••
TL;DR: A theoretical and statistical framework to determine DNA termini and phage packaging mechanisms using NGS data is developed and validated using a set of phages with well-established packaging mechanisms representative of the termini diversity.
Abstract: The worrying rise of antibiotic resistance in pathogenic bacteria is leading to a renewed interest in bacteriophages as a treatment option. Novel sequencing technologies enable description of an increasing number of phage genomes, a critical piece of information to understand their life cycle, phage-host interactions, and evolution. In this work, we demonstrate how it is possible to recover more information from sequencing data than just the phage genome. We developed a theoretical and statistical framework to determine DNA termini and phage packaging mechanisms using NGS data. Our method relies on the detection of biases in the number of reads, which are observable at natural DNA termini compared with the rest of the phage genome. We implemented our method with the creation of the software PhageTerm and validated it using a set of phages with well-established packaging mechanisms representative of the termini diversity, i.e. 5′cos (Lambda), 3′cos (HK97), pac (P1), headful without a pac site (T4), DTR (T7) and host fragment (Mu). In addition, we determined the termini of nine Clostridium difficile phages and six phages whose sequences were retrieved from the Sequence Read Archive. PhageTerm is freely available (https://sourceforge.net/projects/phageterm), as a Galaxy ToolShed and on a Galaxy-based server (https://galaxy.pasteur.fr).
355 citations
••
TL;DR: The role of inflammation in the pathogenesis of CF lung disease is examined, the results of past clinical trials are summarized, and promising new anti-inflammatory options are explored.
354 citations
••
TL;DR: In this article, the authors discuss analytical methods to overcome the challenges of limited data availability, the substantial individual heterogeneity typical of wild populations, incomplete capture histories, and trade-offs across the life span.
Abstract: Summary
1A major current challenge in ageing research is to understand why senescence rates vary between individuals, populations and species in wild populations.
2Recent studies clearly illustrate that senescent declines in key demographic and life-history traits can be observed in many wild animal systems.
3Here, we summarize the key challenges facing researchers working to understand senescence in the wild. We concentrate on: (i) limited data availability, (ii) the substantial individual heterogeneity typical of wild populations, (iii) incomplete capture histories, and (iv) trade-offs across the life span.
4We discuss analytical methods to overcome these challenges. We advocate the use of Capture–Mark–Recapture models to remove likely bias associated with re-sampling rates of less than one. We also illustrate that ageing trajectories may vary between different traits in wild populations. Wherever possible, researchers should examine ageing patterns in multiple traits.
5Numerous models are available to describe the rate and shape of senescence in free-living populations, but there is currently little consensus regarding which is most appropriate in analyses of wild organisms.
6We argue that only longitudinal studies of marked or recognizable individuals provide reliable sources of information in the study of senescence. Senescence is a within-individual process and only longitudinal studies allow researchers to separate within-individual ageing patterns from between-individual heterogeneity.
7We examine two analytical approaches to measure ageing using longitudinal data from wild populations: a jack-knifing approach, well-suited to modelling survival probability, and a mixed-effects model approach. Both methods control for sources of between-individual heterogeneity to allow more accurate measurement of within-individual ageing patterns.
352 citations
••
TL;DR: In this paper, the mechanism and kinetics of the hydrogen evolution reaction (HER) were studied in 1 M NaOH on polycrystalline nickel electrodes using potential step charging, open circuit potential decay and ac impedance techniques.
351 citations
Authors
Showing all 15051 results
Name | H-index | Papers | Citations |
---|---|---|---|
Masashi Yanagisawa | 130 | 524 | 83631 |
Joseph V. Bonventre | 126 | 596 | 61009 |
Jeffrey L. Benovic | 99 | 264 | 30041 |
Alessio Fasano | 96 | 478 | 34580 |
Graham Pawelec | 89 | 572 | 27373 |
Simon C. Robson | 88 | 552 | 29808 |
Paul B. Corkum | 88 | 576 | 37200 |
Mario Leclerc | 88 | 374 | 35961 |
Stephen M. Collins | 86 | 320 | 25646 |
Ed Harlow | 86 | 190 | 61008 |
William D. Fraser | 85 | 827 | 30155 |
Jean Cadet | 83 | 372 | 24000 |
Vincent Giguère | 82 | 227 | 27481 |
Robert Gurny | 81 | 396 | 28391 |
Jean-Michel Gaillard | 81 | 410 | 26780 |