Showing papers by "Université libre de Bruxelles published in 1974"
TL;DR: In this paper, the polar spaces of possibly infinite rank having some line of two points are classified and the Buekenhout-Shult theorems for polar spaces are proven.
Abstract: One of the two Buekenhout-Shult theorems for polar spaces required a finite rank assumption. Here we get rid of that restriction. Similarly, the polar spaces of possibly infinite rank having some line of two points are classified.
182 citations
TL;DR: It is concluded that the resolution of auditory-visual spatial conflict involves recalibrations of both visual and auditory data and that these alterations last long enough to be detected as after-effects.
Abstract: Subjects were tested for both ear-hand and eye-hand co-ordination before and after monitoring a synchronous series of noise bursts and of light flashes coming from the same spatial position, but wi...
167 citations
TL;DR: In this paper, the thermal racemisation in solution of hepta-, octa-and nonahelicene has been studied and a "conformational pathway" is suggested for these racemisations.
147 citations
TL;DR: Direct evidence is provided that DaNa interferes with the intracellular movements of calcium ions in skeletal muscle fibres.
Abstract: DANTROLENE sodium or 1–[5–(p-nitrophenyl) furfurylidene amino] hydantoin sodium hydrate (DaNa) is a long-acting drug with skeletal muscle relaxant properties which has recently seemed clinically useful in the treatment of some types of muscle hypertonia1,2. DaNa does not affect neuromuscular transmission nor the electrical properties of skeletal muscle3 and it apparently involves the processes of excitation–contraction coupling1,3,4. The mode of action of DaNa has not been studied before on single muscle fibres and here we provide direct evidence that DaNa interferes with the intracellular movements of calcium ions.
128 citations
TL;DR: In this article, the thermal cracking of phenol and ortho and para-cresol at atmospheric pressure, between 665°c and 865°C has been studied with a contact time of 2·5 seconds.
120 citations
TL;DR: Endotracheal administration of gentamicin has been compared with saline injections in a double-blind study of 85 patients admitted to a neurosurgical unit with tracheostomy and reduced significantly the incidence of colonization of the tracheal secretions by Gram-negative rods.
112 citations
TL;DR: Mutants lacking NADP-linked glutamate dehydrogenase (NADP-GDH) activity have been isolated by several procedures as discussed by the authors, including several procedures based on several procedures.
Abstract: Mutants lacking NADP-linked glutamate dehydrogenase (NADP-GDH) activity have been isolated by several procedures
105 citations
TL;DR: It is suggested that microtubules indeed participate in the dynamics of insulin release, a reduction of both phases of insulin secretion being caused by an extended disruption of the microtubular apparatus, whereas a more limited disturbance of themicrotubular system appears to be associated with facilitated insulin release in response to either glucose or sulfonylurea.
Abstract: In order to document the participation of microtubules in the dynamics of insulin release, the secretory response of the isolated perfused rat pancreas was measured after various times of exposure to vincristine (2.10−5M). After a short exposure time (25 min), both phases of glucose-induced insulin release were increased. After longer pretreatment (60 min), this facilitating effect disappeared and a slight, insignificant reduction of both phases of the secretory response to glucose was observed. A still longer exposure time (120 min) provoked a more marked and significant inhibition of the early and late phases of insulin release. The same enhancing effect after short pretreatment with vincristine was noticed when gliclazide was used as the insulinotropic agent. The ultrastructural studies indicated a progressive disappearance of microtubules concomitantly with an increase in number and size of vincristine-induced paracrystalline deposits. These findings suggest that microtubules indeed participate in the dynamics of insulin release, a reduction of both phases of insulin secretion being caused by an extended disruption of the microtubular apparatus, whereas a more limited disturbance of the microtubular system appears to be associated with facilitated insulin release in response to either glucose or sulfonylurea.
97 citations
95 citations
93 citations
TL;DR: In this paper, the basic apparatus of collision theory for nonrelativistic potential problems is first developed, and the Born and eikonal series are introduced, and a general analysis is then given of multiple scattering expansions for several particle problems.
Abstract: The problem of quantum collisions involving several particle systems is reviewed within the framework of multiple scattering theory. The basic apparatus of collision theory for nonrelativistic potential problems is first developed, and the Born and eikonal series are introduced. A general analysis is then given of multiple scattering expansions for several particle problems. We discuss in particular the Born developments, the Faddeev-Watson expansions, the Glauber method, and various multiple scattering approaches to the determination of the optical potential. Applications to atomic collision problems and to high-energy hadron-deuteron scattering are discussed at length. © 1974 American Physical Society.
TL;DR: Adriamycin-DNA induces very high percentages of increase in life span in DBA 2 mice inoculated intravenously with L 1210 cells and allows a great proportion of mice to survive longer than 30 days and all these data are in favor of a lysosomotropic mode of action of adriamyin-DNA.
TL;DR: In this article, the UV, ORD and CD curves of the pure enantiomers are shown in Figs 1, 2, and 3, and the UV and ORD curves for the pure Enantiomers were obtained by repeated crystallisation under equilibnim conditions.
TL;DR: It is emphasized that the overall system bandpass should extend to 3 kc/sec when studying the early components and when estimating the onset latency of the surface negative N 1 component.
TL;DR: The results strongly support the hypothesis that folding of polypeptide chains can occur through a nucleation process that could be induced by the side-chains.
TL;DR: The study of carbamoylphosphate synthesizing activities of these mutants and the combination of car mutations in various in vivo as well as in vitro complementation tests lead to the conclusion that car contains two genes: carA, covering the left part of the locus and coding for the “glutamine subunit” of the enzyme; carB, to the right, governing the synthesis of the heavy subunit of the enzymes.
Abstract: 76 mutants have been isolated in which the function of the single carbamoylphosphate synthetase of Escherichia coli K 12 is affected. A wide variety of phenotypes have been observed among these mutants, the most typical ones being: requirement for arginine and uracil, arginineless behaviour, sensitivity towards arginine and sensitivity towards uracil. The mutations have been localized by reciprocal transduction and deletion mapping; all are clustered in the same locus, car. The study of carbamoylphosphate synthesizing activities of these mutants and the combination of car mutations in various in vivo as well as in vitro complementation tests lead to the conclusion that car contains two genes: carA, covering the left part of the locus and coding for the “glutamine subunit” of the enzyme; carB, to the right, governing the synthesis of the heavy subunit of the enzyme.
TL;DR: Arguments supporting the view that plasma FFA participate in the regulation of glucose metabolism in man are provided.
Abstract: In order to determine whether increased plasma free fatty acid (FFA) levels inhibit glucose utilization in man, glucose metabolism was studied in 8 normal subjects both under basal conditions and during experimental elevations of plasma FFA concentrations induced by the administration of high fat meals and heparin. A primed constant infusion of 1 14C glucose was used to measure the rate of turnover, the fractional removal rate and the rate of oxidation of plasma glucose under both experimental conditions. Elevations of FFA levels (+117%) were accompanied by a 9% reduction in both the fractional removal rate of glucose and the hepatic glucose production so that glycaemia remained unchanged. The % glucose converted to CO2 and the % CO2 derived from plasma glucose decreased respectively by 13.5% and 21.7%, while unlabelled CO2 production remained unchanged. This reduction in glucose utilization occurred despite a significant rise in insulin concentration indicating that high FAA levels reduce sensitivity to insulin. The tissue implicated in the inhibitory effect of FAA on overall glucose utilization cannot be determined from these experiments but it is suggested that muscle participated in these metabolic changes. These data provide further arguments supporting the view that plasma FFA participate in the regulation of glucose metabolism in man. (25 references.)
TL;DR: The paper by J. Keizer and R. F. Fox entitled "Qualms Regarding the Range of Validity of the Glansdorff-Prigogine Criterion for Stability of Non-Equilibrium States" is shown to be based on a misunderstanding of the work of the Brussels group and the formulation of the stability criterion is summarized.
Abstract: The paper by J. Keizer and R. F. Fox entitled “Qualms Regarding the Range of Validity of the Glansdorff-Prigogine Criterion for Stability of Non-Equilibrium States” [(1974) Proc. Nat. Acad. Sci. USA 71, 192-196.] is shown to be based on a misunderstanding of the work of the Brussels group. In order to avoid further confusion, we summarize the formulation of the stability criterion in accordance with our published work. The differences with the presentation by Keizer and Fox are pointed out and it is shown that, when correctly applied, our approach does not lead to any contradiction with other methods available for studying stability.
TL;DR: A model chemical network involving reactions and diffusion is studied, and spatially and temporally ordered solutions of the equations are found by bifurcation theory.
Abstract: A model chemical network involving reactions and diffusion is studied Spatially and temporally ordered solutions of the equations are found by bifurcation theory These solutions are calculated analytically and their stability is studied Properties of these dissipative structures are discussed, and a comparison with Thom's theories of morphogenesis is outlined
TL;DR: The data indicate that each molecule of human triacylglycerol lipase can easily react with one molecule of bovine colipase, and less easily with two or more molecules.
TL;DR: The basal cortisol levels of patients with hyperadrenalcorticism were considerably elevated; the basal rhythmicity persisted but its amplitude was significantly reduced; a significant difference between night and day TSH levels wa...
Abstract: In order to investigate the interrelationships between the circadian patterns of cortisoland TSH, serum levels of each hormone were measured every 30 min for 24 hr in 8 normal subjects and in 2 patients with active Cushing's syndrome. The well-known daily time-course of cortisol levels was observed in all normal subjects except one. A proper statistical analysis, the periodogram method, provided a quantitative description of the basal rhythmicity in terms of a sinusoid of amplitude ranging, in normal subjects, from 50 to 100% of the mean. The basal cortisol levels of patients with hyperadrenalcorticism were considerably elevated; the basal rhythmicity persisted but its amplitude was significantly reduced. In 7 of the 8 normal subjects, the daily rhythm of TSH levels was characterized by a peak between 3 am and 7 am whose height ranged from 33% to 335% of the basal value; all subjects displayed high frequency variations of low amplitude; a significant difference between night and day TSH levels wa...
TL;DR: It is concluded that the glucagon stimulation test is a safe, easy, and reliable test to study pituitary GH reserve in children.
TL;DR: Clinical correlates are consistent in showing that the affected muscles are influenced by even small local temperature changes, such as occur in daily living, and this suggests a number of practical recommendations which can help these patients.
TL;DR: The polarographie impulsionnelle differentielle permet de separer et de doser 0,12 mg de cysteine and 0,24 mg of cystine par litre as discussed by the authors.
TL;DR: In this article, a bacterial activity involving mineralization of methylmercury was found in bottom sediments of the river Sambre (Belgium), in a zone highly polluted with inorganic mercury.
TL;DR: It is concluded that isometric exercise tests are unsuitable for diagnosing coronary insufficiency and should not be used for such tests.
Abstract: Forty-six patients with arteriosclerotic heart disease manifested significant electrocardiographic changes (accompanied by angina in 35) during maximal exercise testing. These patients subsequently performed isometric exercise at levels representing various percentages of maximal voluntary contraction. Twenty-two patients also performed combined isometric and submaximal dynamic exercise. The prevalence rate of S-T segment changes during isolated isometric exercise depended on the percent of maximal voluntary contraction applied but was far lower than the rate observed during maximal dynamic exercise. Angina seldom occurred. Manifestations of coronary insufficiency appeared more often during combined submaximal dynamic and isometric exercise than during isolated isometric testing. Aortic pressure was measured in eight cases. Tension-time index and pressure-heart rate product were lower when maximal dynamic exercise was stopped owing to coronary insufficiency than at the end of isolated isometric exercise or combined submaximal dynamic and isometric exercise. However, the latter two tests produced fewer ischemic manifestations. The reasons for these discrepancies are discussed. We conclude that isometric exercise tests are unsuitable for diagnosing coronary insufficiency.
TL;DR: The escape of several enzymes from “ammonia catabolite repression” in gdhA − and gdhCR mutants, as well as in g dhCR mutants of Saccharomyces cerevisiae, does not involve glutamine synthetase, either as a positive or as a negative control element.
TL;DR: The clinical results were much better in urinary tract infections than in wound infections, pulmonary infections, septicemia, and meningitis, and the frequency of adverse reactions encountered in the present series was similar for both drugs.
Abstract: Gentamicin and tobramycin have been compared in vitro and as single-drug therapy in patients with a serious infection caused by gram-negative rods. In vitro, a slight advantage of tobramycin over gentamicin has been found against Pseudomonas aeruginosa. Cross-resistance between gentamicin and tobramycin has been observed for gentamicin-resistant strains of P. aeruginosa and Providence but was not always present. The clinical effectiveness of gentamicin and tobramycin was similar: 14 (45.1%) out of the 31 patients in each series responded favorably. The clinical results were much better in urinary tract infections (66% of favorable responses) than in wound infections, pulmonary infections, septicemia, and meningitis (26% of favorable responses). The frequency of adverse reactions encountered in the present series was similar for both drugs.
TL;DR: This paper found that subjects were faster in judging the syllables "different" when the second syllable came to the right than to the left ear, but there was no ear difference for "same" judgments.
TL;DR: The first foragers to leave their nest emit the largest amounts of attractive pheromones and also give the best responses to these secretions, of functional significance for the society.
Abstract: The workers of four colonies ofMyrmica rubra were separated into 5 different age categories on the basis of their degree of pigmentation (fig. 1).