Université libre de Bruxelles

About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.

Massive binaries as the source of abundance anomalies in globular clusters

Abstract: Abundance anomalies observed in globular cluster stars indicate pollution with material processed by hydrogen burning. Two main sources have been suggested: asymptotic giant branch (AGB) stars and massive stars rotating near the break-up limit (spin stars). We propose massive binaries as an alternative source of processed material. We compute the evolution of a 20 M star in a close binary considering the effects of non conservative mass and angular momentum transfer and of rotation and tidal interaction to demonstrate the principle. We find that this system sheds about 10 M of material, nearly the entire envelope of the primary star. The ejecta are enriched in He, N, Na, and Al and depleted in C and O, similar to the abundance patterns observed in gobular cluster stars. However, Mg is not significantly depleted in the ejecta of this model. In contrast to the fast, radiatively driven winds of massive stars, this material is typically ejected with low velocity. We expect that it remains inside the potential well of a globular cluster and becomes available for the formation or pollution of a second generation of stars. We estimate that the amount of processed low-velocity material ejected by massive binaries is greater than the contribution of AGB stars and spin stars combined, assuming that the majority of massive stars in a proto-globular cluster interact with a companion and return their envelope to the interstellar medium. If we take the possible contribution of intermediate mass stars in binaries into account and assume that the ejecta are diluted with an equal amount of unprocessed material, we find that this scenario can potentially provide enough material to form a second generation of low-mass stars, which is as numerous as the first generation of low-mass stars, without the need to make commonly adopted assumptions, such as preferential loss of the first generation of stars, external pollution of the cluster, or an anomalous initial mass function.

Illiterate to literate: behavioural and cerebral changes induced by reading acquisition

Abstract: The acquisition of literacy transforms the human brain. By reviewing studies of illiterate subjects, we propose specific hypotheses on how the functions of core brain systems are partially reoriented or 'recycled' when learning to read. Literacy acquisition improves early visual processing and reorganizes the ventral occipito-temporal pathway: responses to written characters are increased in the left occipito-temporal sulcus, whereas responses to faces shift towards the right hemisphere. Literacy also modifies phonological coding and strengthens the functional and anatomical link between phonemic and graphemic representations. Literacy acquisition therefore provides a remarkable example of how the brain reorganizes to accommodate a novel cultural skill.

From R&D to Productivity Growth: Do the Institutional Settings and the Source of Funds of R&D Matter?

Abstract: This paper presents estimates of the long-term impact of various sources of knowledge (R&D performed by the business sector, the public sector and foreign firms) on multifactor productivity growth of 16 countries from 1980 to 1998. The main results show that the three sources of knowledge are significant determinants of long-term productivity growth. Further evidence suggests that several factors determine the extent to which each source of knowledge contributes to productivity growth. These factors are the absorptive capability, the origin of funding, the socioeconomic objectives of government support, and the type of public institutions that perform R&D.

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group Part 2 TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non–Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors

Abstract: Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as immunotherapies are evaluated and implemented in different tumor types. However, many different approaches can be used to assess and describe the immune response, which limits efforts at implementation as a routine clinical biomarker. In part 1 of this review, we have proposed a standardized methodology to assess tumor-infiltrating lymphocytes (TILs) in solid tumors, based on the International Immuno-Oncology Biomarkers Working Group guidelines for invasive breast carcinoma. In part 2 of this review, we discuss the available evidence for the prognostic and predictive value of TILs in common solid tumors, including carcinomas of the lung, gastrointestinal tract, genitourinary system, gynecologic system, and head and neck, as well as primary brain tumors, mesothelioma and melanoma. The particularities and different emphases in TIL assessment in different tumor types are discussed. The standardized methodology we propose can be adapted to different tumor types and may be used as a standard against which other approaches can be compared. Standardization of TIL assessment will help clinicians, researchers and pathologists to conclusively evaluate the utility of this simple biomarker in the current era of immunotherapy.