Université libre de Bruxelles

About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.

Further explorations of Skyrme-Hartree-Fock-Bogoliubov mass formulas. XII. Stiffness and stability of neutron-star matter

Abstract: We construct three new Hartree-Fock-Bogoliubov (HFB) mass models, labeled HFB-19, HFB20, and HFB-21, with unconventional Skyrme forces containing t4 and t5 terms, i.e., densitydependent generalizations of the usual t1 and t2 terms, respectively. The new forces underlying these models are fitted respectively to three different realistic equations of state of neutron matter for which the density dependence of the symmetry energy ranges from the very soft to the very stiff, reflecting thereby our present lack of complete knowledge of the high-density behavior of nuclear matter. All unphysical instabilities of nuclear matter, including the transition to a polarized state in neutron-star matter, are eliminated with the new forces. At the same time the new models fit essentially all the available mass data with rms deviations of 0.58 MeV and give the same high quality fits to measured charge radii that we obtained in earlier models with conventional Skyrme forces. Being constrained by neutron matter, these new mass models, which all give similar extrapolations out to the neutron drip line, are highly appropriate for studies of the r-process and the outer crust of neutron stars. Moreover, the underlying forces, labeled BSk19, BSk20 and BSk21, respectively, are well adapted to the study of the inner crust and core of neutron stars. The new family of Skyrme forces thus opens the way to a unified description of all regions of neutron stars.

Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer

Abstract: Background Patients with metastatic triple-negative breast cancer have a poor prognosis. Sacituzumab govitecan is an antibody–drug conjugate composed of an antibody targeting the human tro...

An Ant Colony System Hybridized with a New Local Search for the Sequential Ordering Problem

Abstract: We present a new local optimizer called SOP-3-exchange for the sequential ordering problem that extends a local search for the traveling salesman problem to handle multiple constraints directly without increasing computational complexity. An algorithm that combines the SOP-3-exchange with an Ant Colony Optimization algorithm is described, and we present experimental evidence that the resulting algorithm is more effective than existing methods for the problem. The best-known results for many of a standard test set of 22 problems are improved using the SOP-3-exchange with our Ant Colony Optimization algorithm or in combination with the MPO/AI algorithm (Chen and Smith 1996).

p53 and breast cancer, an update

Abstract: p53 plays a key role in mediating cell response to various stresses, mainly by inducing or repressing a number of genes involved in cell cycle arrest, senescence, apoptosis, DNA repair, and angiogenesis. According to this important function, p53 activity is controlled in a very complex manner, including several auto-regulatory loops, through the intervention of dozens of modulator proteins (the ‘p53 interactome’). p53 mutations are observed in a significant minority of breast tumours. In the remaining cases, alterations of interactome components or target genes could contribute, to some extent, to reduce the ability of p53 to efficiently manage stress events. While the prognostic and predictive value of p53 is still debated, there is an increasing interest for p53-based therapies. The present paper aims to provide updated information on p53 regulation and function, with specific interest on its role in breast cancer. Endocrine-Related Cancer (2006) 13 293–325