Institution
Université libre de Bruxelles
Education•Brussels, Belgium•
About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.
Topics: Population, Breast cancer, Context (language use), Receptor, Cancer
Papers published on a yearly basis
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TL;DR: The finding suggests that a common receptor gene family encodes olfactory receptors and sperm cell receptors that could be involved in chemotaxis during fertilization.
Abstract: A series of genomic and complementary DNA clones encoding new putative members of G protein-coupled receptors were isolated using homology cloning and low-stringency polymerase chain reaction. Among the unidentified receptors ('orphan receptors'), a human genomic clone (HGMP07) was characterized by the presence of its transcripts in the testis and by its belonging to a large subfamily of genes sharing extensive sequence similarities. Sequence comparison demonstrated that this gene subfamily is the human counterpart of the putative rat olfactory receptors cloned recently. Another 48 members of the family were cloned. Northern blotting further demonstrated the presence of olfactory receptor transcripts in germ cells. Our finding suggests that a common receptor gene family encodes olfactory receptors and sperm cell receptors that could be involved in chemotaxis during fertilization.
375 citations
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Xishuangbanna Tropical Botanical Garden1, Columbia University2, National Institute of Amazonian Research3, Universidade Federal do Acre4, Philadelphia Zoo5, Empresa Brasileira de Pesquisa Agropecuária6, Wageningen University and Research Centre7, Duke University8, Zoological Society of London9, London School of Economics and Political Science10, Université libre de Bruxelles11, Gembloux Agro-Bio Tech12, Museu Paraense Emílio Goeldi13, World Wide Fund for Nature14, University of Amsterdam15, Royal Botanic Garden Edinburgh16, Wildlife Conservation Society17, Center for International Forestry Research18, University of Oxford19, Universiti Sains Malaysia20, Universidad Autónoma Gabriel René Moreno21, Kyoto University22, University of Bangka Belitung23, University of North Sumatra24, University of Zurich25, University of Los Andes26, Indonesian Institute of Sciences27, Southern Cross University28, Naturalis29, Missouri Botanical Garden30, Universidad Nacional de la Amazonía Peruana31, Kagoshima University32, University of Copenhagen33, Smithsonian Tropical Research Institute34, University of Wisconsin–Milwaukee35, Liverpool John Moores University36, Chinese Academy of Sciences37
TL;DR: In this paper, the importance of large trees for tropical forest biomass storage and explore which intrinsic (species trait) and extrinsic (environment) variables are associated with the density of trees and forest biomass at continental and pan-tropical scales.
Abstract: Aim Large trees (d.b.h. 70 cm) store large amounts of biomass. Several studies suggest that large trees may be vulnerable to changing climate, poten- tially leading to declining forest biomass storage. Here we determine the importance of large trees for tropical forest biomass storage and explore which intrinsic (species trait) and extrinsic (environment) variables are associated with the density of large trees and forest biomass at continental and pan-tropical scales. Location Pan-tropical.
375 citations
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TL;DR: In this article, the role of long wave length hydrodynamical processes in the analysis of time-dependent correlation functions is discussed and various tools and methods which are used to describe these processes are discussed.
375 citations
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TL;DR: In this article, the authors reported the observation of gravitational waves from two compact binary coalescences in LIGO's and Virgo's third observing run with properties consistent with neutron star-black hole (NSBH) binaries.
Abstract: We report the observation of gravitational waves from two compact binary coalescences in LIGO’s and Virgo’s third observing run with properties consistent with neutron star–black hole (NSBH) binaries. The two events are named GW200105_162426 and GW200115_042309, abbreviated as GW200105 and GW200115; the first was observed by LIGO Livingston and Virgo and the second by all three LIGO–Virgo detectors. The source of GW200105 has component masses 8.9−1.5+1.2 and 1.9−0.2+0.3M⊙ , whereas the source of GW200115 has component masses 5.7−2.1+1.8 and 1.5−0.3+0.7M⊙ (all measurements quoted at the 90% credible level). The probability that the secondary’s mass is below the maximal mass of a neutron star is 89%–96% and 87%–98%, respectively, for GW200105 and GW200115, with the ranges arising from different astrophysical assumptions. The source luminosity distances are 280−110+110 and 300−100+150Mpc , respectively. The magnitude of the primary spin of GW200105 is less than 0.23 at the 90% credible level, and its orientation is unconstrained. For GW200115, the primary spin has a negative spin projection onto the orbital angular momentum at 88% probability. We are unable to constrain the spin or tidal deformation of the secondary component for either event. We infer an NSBH merger rate density of 45−33+75Gpc−3yr−1 when assuming that GW200105 and GW200115 are representative of the NSBH population or 130−69+112Gpc−3yr−1 under the assumption of a broader distribution of component masses.
374 citations
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TL;DR: The predictive power of this method, based on a formalism that highlights the coupling between four protein sequence and structure descriptors, and take into account the amino acid volume variation upon mutation, is shown to be significantly higher than that of other programs described in the literature.
Abstract: Motivation: The rational design of proteins with modified properties, through amino acid substitutions, is of crucial importance in a large variety of applications. Given the huge number of possible substitutions, every protein engineering project would benefit strongly from the guidance of in silico methods able to predict rapidly, and with reasonable accuracy, the stability changes resulting from all possible mutations in a protein.
Results: We exploit newly developed statistical potentials, based on a formalism that highlights the coupling between four protein sequence and structure descriptors, and take into account the amino acid volume variation upon mutation. The stability change is expressed as a linear combination of these energy functions, whose proportionality coefficients vary with the solvent accessibility of the mutated residue and are identified with the help of a neural network. A correlation coefficient of R = 0.63 and a root mean square error of σc = 1.15 kcal/mol between measured and predicted stability changes are obtained upon cross-validation. These scores reach R = 0.79, and σc = 0.86 kcal/mol after exclusion of 10% outliers. The predictive power of our method is shown to be significantly higher than that of other programs described in the literature.
Availability: http://babylone.ulb.ac.be/popmusic
Contact: ydehouck@ulb.ac.be
Supplementary information:Supplementary data are available at Bioinformatics online.
373 citations
Authors
Showing all 25206 results
Name | H-index | Papers | Citations |
---|---|---|---|
Karl J. Friston | 217 | 1267 | 217169 |
Yi Chen | 217 | 4342 | 293080 |
David Miller | 203 | 2573 | 204840 |
Jing Wang | 184 | 4046 | 202769 |
H. S. Chen | 179 | 2401 | 178529 |
Jie Zhang | 178 | 4857 | 221720 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
D. M. Strom | 176 | 3167 | 194314 |
J. N. Butler | 172 | 2525 | 175561 |
Andrea Bocci | 172 | 2402 | 176461 |
Bradley Cox | 169 | 2150 | 156200 |
Marc Weber | 167 | 2716 | 153502 |
Hongfang Liu | 166 | 2356 | 156290 |
Guenakh Mitselmakher | 165 | 1951 | 164435 |
Yang Yang | 164 | 2704 | 144071 |