Institution
Université libre de Bruxelles
Education•Brussels, Belgium•
About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.
Topics: Population, Breast cancer, Context (language use), Receptor, Cancer
Papers published on a yearly basis
Papers
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Utrecht University1, United States Department of Energy2, National Autonomous University of Mexico3, National and Kapodistrian University of Athens4, University of Debrecen5, Commonwealth Scientific and Industrial Research Organisation6, Leiden University7, Maynooth University8, University of Göttingen9, University of Seville10, University of Natural Resources and Life Sciences, Vienna11, Broad Institute12, Huazhong Agricultural University13, State University of Campinas14, International Sleep Products Association15, Université libre de Bruxelles16, University of Nottingham17, Aix-Marseille University18, Pasteur Institute19, Institut national de la recherche agronomique20, King Abdulaziz University21, University of Helsinki22, University of Amsterdam23, University of St Andrews24, University of Ioannina25, Saint Petersburg State University26, Spanish National Research Council27, Federal University of São Carlos28, Swedish University of Agricultural Sciences29, Technical University of Berlin30, National Scientific and Technical Research Council31, Concordia University32, Kyungpook National University33, University of the Republic34, Karlsruhe Institute of Technology35, University of Sulaymaniyah36, University of Ljubljana37, Leibniz Association38, Stanford University39, Kansas State University40, Technical University of Denmark41, University of Wisconsin-Madison42, Pacific Northwest National Laboratory43, University of Jena44, University of São Paulo45, University of Kansas46, Imperial College London47, Université Paris-Saclay48, Vienna University of Technology49
TL;DR: In this article, a comparative genomics and experimental study of the aspergilli genus is presented, which allows for the first time a genus-wide view of the biological diversity of the Aspergillus and in many, but not all, cases linked genome differences to phenotype.
Abstract: Background: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. Conclusions: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.
349 citations
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TL;DR: How genetic engineering has yielded new insights into how the lignin biosynthetic pathway operates is described and it is demonstrated that lignIn can be improved to facilitate pulping.
Abstract: Lignin is a major component of wood, the most widely used raw material for the production of pulp and paper. Although the biochemistry and molecular biology underpinning lignin production are better understood than they are for the other wood components, recent work has prompted a number of re-evaluations of the lignin biosynthetic pathway. Some of the work on which these revisions have been based involved the investigation of transgenic plants with modified lignin biosynthesis. In addition to their value in elucidating the lignin biosynthetic pathway, such transgenic plants are also being produced with the aim of improving plant raw materials for pulp and paper production. This review describes how genetic engineering has yielded new insights into how the lignin biosynthetic pathway operates and demonstrates that lignin can be improved to facilitate pulping. The current technologies used to produce paper are presented in this review, followed by a discussion of the impact of lignin modification on pulp production. Fine-tuned modification of lignin content, composition, or both is now achievable and could have important economic and environmental benefits.
349 citations
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TL;DR: Using regulatory landscapes and in silico analysis, it is shown that transcriptional reprogramming underlies the distinct cellular states present in melanoma and reveals an essential role for the TEADs, linking it to clinically relevant mechanisms such as invasion and resistance.
Abstract: Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct invasive cell subpopulation is a critical event at the origin of metastatic spreading Here we generate transcriptome, open chromatin and histone modification maps of melanoma cultures; and integrate this data with existing transcriptome and DNA methylation profiles from tumour biopsies to gain insight into the mechanisms underlying this key reprogramming event This shows thousands of genomic regulatory regions underlying the proliferative and invasive states, identifying SOX10/MITF and AP-1/TEAD as regulators, respectively Knockdown of TEADs shows a previously unrecognized role in the invasive gene network and establishes a causative link between these transcription factors, cell invasion and sensitivity to MAPK inhibitors Using regulatory landscapes and in silico analysis, we show that transcriptional reprogramming underlies the distinct cellular states present in melanoma Furthermore, it reveals an essential role for the TEADs, linking it to clinically relevant mechanisms such as invasion and resistance
348 citations
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University of Utah1, Saitama University2, Tokyo Institute of Technology3, Ewha Womans University4, Hanyang University5, Tokyo University of Science6, Kindai University7, Yonsei University8, University of Tokyo9, Osaka City University10, Kanagawa University11, University of Yamanashi12, Tokyo City University13, Waseda University14, Chiba University15, Kōchi University16, Ritsumeikan University17, Sungkyunkwan University18, Université libre de Bruxelles19, Ulsan National Institute of Science and Technology20, Rutgers University21, Hiroshima City University22, National Institute of Radiological Sciences23, Ehime University24
TL;DR: In this paper, the authors search for intermediate-scale anisotropy in the arrival directions of ultra-high-energy cosmic rays with energies above 57 EeV in the northern sky using data collected over a 5-year period by the surface detector of the Telescope Array experiment.
Abstract: We have searched for intermediate-scale anisotropy in the arrival directions of ultrahigh-energy cosmic rays with energies above 57 EeV in the northern sky using data collected over a 5 yr period by the surface detector of the Telescope Array experiment. We report on a cluster of events that we call the hotspot, found by oversampling using 20° radius circles. The hotspot has a Li-Ma statistical significance of 5.1σ, and is centered at R.A. = 146.°7, decl. = 43.°2. The position of the hotspot is about 19° off of the supergalactic plane. The probability of a cluster of events of 5.1σ significance, appearing by chance in an isotropic cosmic-ray sky, is estimated to be 3.7 × 10-4 (3.4σ). © 2014. The American Astronomical Society. All rights reserved.
348 citations
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TL;DR: The results strongly support the importance of genetic factors in the transmission of manic-depressive illness.
Abstract: COMPARISON of adoptive parents of persons with a psychiatric disorder with their biological parents provides a unique opportunity to separate the interacting aetiological roles of heredity and environment We have conducted such a study in manic-depressive illness; the results strongly support the importance of genetic factors in the transmission of this disorder
348 citations
Authors
Showing all 25206 results
Name | H-index | Papers | Citations |
---|---|---|---|
Karl J. Friston | 217 | 1267 | 217169 |
Yi Chen | 217 | 4342 | 293080 |
David Miller | 203 | 2573 | 204840 |
Jing Wang | 184 | 4046 | 202769 |
H. S. Chen | 179 | 2401 | 178529 |
Jie Zhang | 178 | 4857 | 221720 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
D. M. Strom | 176 | 3167 | 194314 |
J. N. Butler | 172 | 2525 | 175561 |
Andrea Bocci | 172 | 2402 | 176461 |
Bradley Cox | 169 | 2150 | 156200 |
Marc Weber | 167 | 2716 | 153502 |
Hongfang Liu | 166 | 2356 | 156290 |
Guenakh Mitselmakher | 165 | 1951 | 164435 |
Yang Yang | 164 | 2704 | 144071 |