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Institution

Université libre de Bruxelles

EducationBrussels, Belgium
About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.


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Journal ArticleDOI
Carl A. Anderson1, Gabrielle Boucher2, Charlie W. Lees3, Andre Franke4, Mauro D'Amato5, Kent D. Taylor6, James Lee7, Philippe Goyette2, Marcin Imielinski8, Anna Latiano9, Caroline Lagacé2, Regan Scott10, Leila Amininejad11, Suzannah Bumpstead1, Leonard Baidoo10, Robert N. Baldassano8, Murray L. Barclay12, Theodore M. Bayless13, Stephan Brand14, Carsten Büning15, Jean-Frederic Colombel16, Lee A. Denson17, Martine De Vos18, Marla Dubinsky6, Cathryn Edwards19, David Ellinghaus4, Rudolf S N Fehrmann20, James A B Floyd1, Timothy H. Florin21, Denis Franchimont11, Lude Franke20, Michel Georges22, Jürgen Glas14, Nicole L. Glazer23, Stephen L. Guthery24, Talin Haritunians6, Nicholas K. Hayward25, Jean-Pierre Hugot26, Gilles Jobin2, Debby Laukens18, Ian C. Lawrance27, Marc Lémann26, Arie Levine28, Cécile Libioulle22, Edouard Louis22, Dermot P.B. McGovern6, Monica Milla, Grant W. Montgomery25, Katherine I. Morley1, Craig Mowat29, Aylwin Ng30, William G. Newman31, Roel A. Ophoff32, Laura Papi33, Orazio Palmieri9, Laurent Peyrin-Biroulet, Julián Panés, Anne M. Phillips29, Natalie J. Prescott34, Deborah D. Proctor35, Rebecca L. Roberts12, Richard K Russell36, Paul Rutgeerts37, Jeremy D. Sanderson38, Miquel Sans39, Philip Schumm40, Frank Seibold41, Yashoda Sharma35, Lisa A. Simms25, Mark Seielstad42, Mark Seielstad43, A. Hillary Steinhart44, Stephan R. Targan6, Leonard H. van den Berg32, Morten H. Vatn45, Hein W. Verspaget46, Thomas D. Walters44, Cisca Wijmenga20, David C. Wilson3, Harm-Jan Westra20, Ramnik J. Xavier30, Zhen Zhen Zhao25, Cyriel Y. Ponsioen47, Vibeke Andersen48, Leif Törkvist5, Maria Gazouli49, Nicholas P. Anagnou49, Tom H. Karlsen45, Limas Kupčinskas50, Jurgita Sventoraityte50, John C. Mansfield51, Subra Kugathasan52, Mark S. Silverberg44, Jonas Halfvarson53, Jerome I. Rotter6, Christopher G. Mathew34, Anne M. Griffiths44, Richard B. Gearry12, Tariq Ahmad, Steven R. Brant13, Mathias Chamaillard54, Jack Satsangi3, Judy H. Cho35, Stefan Schreiber4, Mark J. Daly30, Jeffrey C. Barrett1, Miles Parkes7, Vito Annese9, Hakon Hakonarson55, Graham L. Radford-Smith25, Richard H. Duerr10, Severine Vermeire37, Rinse K. Weersma20, John D. Rioux2 
Wellcome Trust Sanger Institute1, Université de Montréal2, University of Edinburgh3, University of Kiel4, Karolinska Institutet5, Cedars-Sinai Medical Center6, University of Cambridge7, University of Pennsylvania8, Casa Sollievo della Sofferenza9, University of Pittsburgh10, Université libre de Bruxelles11, University of Otago12, Johns Hopkins University13, Ludwig Maximilian University of Munich14, Charité15, Lille University of Science and Technology16, Cincinnati Children's Hospital Medical Center17, Ghent University18, Torbay Hospital19, University of Groningen20, Mater Health Services21, University of Liège22, University of Washington23, University of Utah24, QIMR Berghofer Medical Research Institute25, University of Paris26, University of Western Australia27, Tel Aviv University28, University of Dundee29, Harvard University30, University of Manchester31, Utrecht University32, University of Florence33, King's College London34, Yale University35, Royal Hospital for Sick Children36, Katholieke Universiteit Leuven37, Guy's and St Thomas' NHS Foundation Trust38, University of Barcelona39, University of Chicago40, University of Bern41, Agency for Science, Technology and Research42, University of California, San Francisco43, University of Toronto44, University of Oslo45, Leiden University46, University of Amsterdam47, Aarhus University48, National and Kapodistrian University of Athens49, Lithuanian University of Health Sciences50, Newcastle University51, Emory University52, Örebro University53, French Institute of Health and Medical Research54, Center for Applied Genomics55
TL;DR: A meta-analysis of six ulcerative colitis genome-wide association study datasets found many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1.
Abstract: Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

1,291 citations

Journal ArticleDOI
TL;DR: The rationale underlying the iterated racing procedures in irace is described and a number of recent extensions are introduced, including a restart mechanism to avoid premature convergence, the use of truncated sampling distributions to handle correctly parameter bounds, and an elitist racing procedure for ensuring that the best configurations returned are also those evaluated in the highest number of training instances.

1,280 citations

Journal ArticleDOI
TL;DR: In node-positive, ER-negative/HER2-negative BC, increasing lymphocytic infiltration was associated with excellent prognosis and the data also support the evaluation of immunotherapeutic approaches in selected BC subtypes.
Abstract: Purpose Previous preclinical and clinical data suggest that the immune system influences prognosis and response to chemotherapy (CT); however, clinical relevance has yet to be established in breast cancer (BC). We hypothesized that increased lymphocytic infiltration would be associated with good prognosis and benefit from immunogenic CT—in this case, anthracycline-only CT—in selected BC subtypes. Patients and Methods We investigated the relationship between quantity and location of lymphocytic infiltrate at diagnosis with clinical outcome in 2009 node-positive BC samples from the BIG 02-98 adjuvant phase III trial comparing anthracycline-only CT (doxorubicin followed by cyclophosphamide, methotrexate, and fluorouracil [CMF] or doxorubicin plus cyclophosphamide followed by CMF) versus CT combining doxorubicin and docetaxel (doxorubicin plus docetaxel followed by CMF or doxorubicin followed by docetaxel followed by CMF). Readings were independently performed by two pathologists. Disease-free survival (DFS), overall survival (OS), and interaction with type of CT associations were studied. Median follow-up was 8 years.

1,280 citations

Journal ArticleDOI
TL;DR: This critical review covers various aspects of recent research on discotic liquid crystals, in particular, molecular design concepts, supramolecular structure, processing into ordered thin films and fabrication of electronic devices.
Abstract: Discotic (disc-like) molecules typically comprising a rigid aromatic core and flexible peripheral chains have been attracting growing interest because of their fundamental importance as model systems for the study of charge and energy transport and due to the possibilities of their application in organic electronic devices. This critical review covers various aspects of recent research on discotic liquid crystals, in particular, molecular design concepts, supramolecular structure, processing into ordered thin films and fabrication of electronic devices. The chemical structure of the conjugated core of discotic molecules governs, to a large extent, their intramolecular electronic properties. Variation of the peripheral flexible chains and of the aromatic core is decisive for the tuning of self-assembly in solution and in bulk. Supramolecular organization of discotic molecules can be effectively controlled by the choice of the processing methods. In particular, approaches to obtain suitable macroscopic orientations of columnar superstructures on surfaces, that is, planar uniaxial or homeotropic alignment, are discussed together with appropriate processing techniques. Finally, an overview of charge transport in discotic materials and their application in optoelectronic devices is given (234 references).

1,278 citations

Journal ArticleDOI
TL;DR: The results of gene-expression studies that hold the most promise to accelerate the transition between empirical and molecular medicine are summarized.
Abstract: Gene-expression profiling with the use of DNA microarrays allows measurement of thousands of messenger RNA (mRNA) transcripts in a single experiment. Results of such studies have confirmed that breast cancer is not a single disease with variable morphologic features and biomarkers but, rather, a group of molecularly distinct neoplastic disorders. Profiling results also support the hypothesis that estrogen-receptor (ER)–negative and ER-positive breast cancers originate from distinct cell types and point to biologic processes that govern metastatic progression. Moreover, such profiling has uncovered molecular signatures that could influence clinical care. In this review, we summarize the results of gene-expression studies that hold the most promise to accelerate the transition between empirical and molecular medicine.

1,269 citations


Authors

Showing all 25206 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Yi Chen2174342293080
David Miller2032573204840
Jing Wang1844046202769
H. S. Chen1792401178529
Jie Zhang1784857221720
Jasvinder A. Singh1762382223370
D. M. Strom1763167194314
J. N. Butler1722525175561
Andrea Bocci1722402176461
Bradley Cox1692150156200
Marc Weber1672716153502
Hongfang Liu1662356156290
Guenakh Mitselmakher1651951164435
Yang Yang1642704144071
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023119
2022411
20213,194
20203,051
20192,751
20182,609