Institution
Université Nantes Angers Le Mans
Education•Nantes, France•
About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Finite element method. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.
Topics: Geology, Finite element method, Population, Mars Exploration Program, Ultimate tensile strength
Papers
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TL;DR: In this paper, a 3D imaging technique based on X-ray micro-tomography was used to reveal the extent of structural imperfections of additive manufacturing by considering 3D images.
50 citations
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NorthShore University HealthSystem1, Columbia University2, Boston University3, Florey Institute of Neuroscience and Mental Health4, University of Pennsylvania5, Imperial College London6, Wake Forest University7, University of Minnesota8, University of Groningen9, Humboldt University of Berlin10, Université Nantes Angers Le Mans11, University of Göttingen12, National and Kapodistrian University of Athens13, Wrocław Medical University14, Harvard University15, Northwestern University16
TL;DR: The rationale for a therapeutic transcatheter interatrial shunt device in HFpEF is given, and the design of REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I), the first randomized controlled trial of a device-based therapy to reduce left atrial pressure, is described.
Abstract: Heart failure with preserved ejection fraction (HFpEF), a major public health problem with high morbidity and mortality rates, remains difficult to manage because of a lack of effective treatment options. Although HFpEF is a heterogeneous clinical syndrome, elevated left atrial pressure—either at rest or with exertion—is a common factor among all forms of HFpEF and one of the primary reasons for dyspnea and exercise intolerance in these patients. On the basis of clinical experience with congenital interatrial shunts in mitral stenosis, it has been hypothesized that the creation of a left-to-right interatrial shunt to decompress the left atrium (without compromising left ventricular filling or forward cardiac output) is a rational, nonpharmacological strategy for alleviating symptoms in patients with HFpEF. A novel transcatheter interatrial shunt device has been developed and evaluated in patients with HFpEF in single-arm, nonblinded clinical trials. These studies have demonstrated the safety and potential efficacy of the device. However, a randomized, placebo-controlled evaluation of the device is required to further evaluate its safety and efficacy in patients with HFpEF. In this article, we give the rationale for a therapeutic transcatheter interatrial shunt device in HFpEF, and we describe the design of REDUCE Elevated Left Atrial Pressure in Heart Failure (REDUCE LAP-HF I), the first randomized controlled trial of a device-based therapy to reduce left atrial pressure in HFpEF.
Clinical Trial Registration— URL: . Unique identifier: [NCT02600234][1].
[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT02600234&atom=%2Fcirchf%2F9%2F7%2Fe003025.atom
50 citations
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TL;DR: In this paper, the authors present a method to compute the response of a viscoelastic layered half-space to a moving load when interlayer slip is considered, using the Navier equations of equilibrium for each layer in the frequency domain.
50 citations
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TL;DR: Patulin induced acute neurotoxicity on Diptera larvae, indicating the interest of this bioassay as an additional tool for detection of this major mycotoxin in crude extracts.
48 citations
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TL;DR: Results for μ and λ will be used to identify and evaluate solutions for controlling bakery product spoilage and will be incorporated in a predictive model for temperature, water activity, and acid.
47 citations
Authors
Showing all 446 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean-Pierre Benoit | 78 | 428 | 22384 |
Denis Jacquemin | 69 | 623 | 22712 |
Olivier Beauchet | 63 | 320 | 13778 |
Dominique Heymann | 62 | 347 | 13497 |
Paul Calès | 61 | 353 | 14123 |
Jérôme Guicheux | 58 | 238 | 9568 |
Ignacio Anegon | 57 | 265 | 11797 |
Cédric Annweiler | 54 | 346 | 9990 |
Michel Neunlist | 53 | 204 | 9136 |
Patrick Saulnier | 50 | 219 | 13125 |
Bruno Le Bizec | 50 | 295 | 9082 |
Alain Mercat | 49 | 142 | 16603 |
Vincent Rohmer | 48 | 121 | 7090 |
J.C. Bernède | 47 | 345 | 7669 |
Jean-Philippe Antignac | 46 | 171 | 6392 |