Institution
Université Nantes Angers Le Mans
Education•Nantes, France•
About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Finite element method. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.
Topics: Geology, Finite element method, Population, Mars Exploration Program, Ultimate tensile strength
Papers
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TL;DR: The ability of breast-milk lipid species to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies.
Abstract: Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother's milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother's breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced "slower" (n = 15, -1.54 ± 0.42 Z-score) or "faster" (n = 11, -0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the "faster-growth" group (0.56 ± 0.72 vs. -1.59 ± 0.96). Liquid chromatography-mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies.
45 citations
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TL;DR: This review reports on the various molecular anomalies present in GSCs and the predominant role of nanomedicines in the development of radiosensitization strategies.
45 citations
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TL;DR: Context recall, an element of episodic memory, refers to remembering the context in which an event has occurred, such as from whom or to whom information has been transmitted.
Abstract: Background: Alzheimer's disease (AD) is a neurodegenerative disease characterized by a gradual loss of memory. Specifically, context aspects of memory are impaired in AD. Our review sheds light on the neurocognitive mechanisms of this memory component that forms the core of episodic memory function. Summary: Context recall, an element of episodic memory, refers to remembering the context in which an event has occurred, such as from whom or to whom information has been transmitted. Key Messages: Our review raises crucial questions. For example, (1) which context element is more prone to being forgotten in the disease? (2) How do AD patients fail to bind context features together? (3) May distinctiveness heuristic or decisions based on metacognitive expectations improve context retrieval in these patients? (4) How does cueing at retrieval enhance reinstating of encoding context in AD? By addressing these questions, our work contributes to the understanding of the memory deficits in AD.
45 citations
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TL;DR: It can be concluded that the origin of EAE exacerbation in PrPc-ablated mice resides in the absence of the prion protein in the central nervous system, highlighting the critical role ofPrPc in maintaining the integrity of the CNS in situations of stress, especially during a neuroinflammatory insult.
Abstract: Background
The cellular prion protein (PrPc) is a host-encoded glycoprotein whose transconformation into PrP scrapie (PrPSc) initiates prion diseases. The role of PrPc in health is still obscure, but many candidate functions have been attributed to the protein, both in the immune and the nervous systems. Recent data show that experimental autoimmune encephalomyelitis (EAE) is worsened in mice lacking PrPc. Disease exacerbation has been attributed to T cells that would differentiate into more aggressive effectors when deprived of PrPc. However, alternative interpretations such as reduced resistance of neurons to autoimmune insult and exacerbated gliosis leading to neuronal deficits were not considered.
44 citations
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TL;DR: The impact of soil on the bioavailability of indicator PCBs was assessed by means by a relative bioavailability (RBA) trial, in which their deposition in egg yolk and in abdominal fat, in response to their ingestion through contaminated-soil and through spiked-oil were compared.
43 citations
Authors
Showing all 446 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean-Pierre Benoit | 78 | 428 | 22384 |
Denis Jacquemin | 69 | 623 | 22712 |
Olivier Beauchet | 63 | 320 | 13778 |
Dominique Heymann | 62 | 347 | 13497 |
Paul Calès | 61 | 353 | 14123 |
Jérôme Guicheux | 58 | 238 | 9568 |
Ignacio Anegon | 57 | 265 | 11797 |
Cédric Annweiler | 54 | 346 | 9990 |
Michel Neunlist | 53 | 204 | 9136 |
Patrick Saulnier | 50 | 219 | 13125 |
Bruno Le Bizec | 50 | 295 | 9082 |
Alain Mercat | 49 | 142 | 16603 |
Vincent Rohmer | 48 | 121 | 7090 |
J.C. Bernède | 47 | 345 | 7669 |
Jean-Philippe Antignac | 46 | 171 | 6392 |