Institution
Université Nantes Angers Le Mans
Education•Nantes, France•
About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Population. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.
Papers
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TL;DR: The data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.
Abstract: Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role of semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) in human T cell precursors. NRP2 and SEMA3F are expressed in the human thymus, in both lymphoid and non-lymphoid compartments. SEMA3F have a repulsive effect on thymocyte migration and inhibited CXCL12- and sphingosine-1-phosphate (S1P)-induced thymocyte migration by inhibiting cytoskeleton reorganization prior to stimuli. Moreover, NRP2 and SEMA3F are expressed in human T-cell acute lymphoblastic leukemia/lymphoma primary cells. In these tumor cells, SEMA3F also blocks their migration induced by CXCL12 and S1P. Our data show that SEMA3F and NRP2 are further regulators of human thymocyte migration in physiological and pathological conditions.
42 citations
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TL;DR: It is demonstrated that PSO consumption improved significantly bone mineral density and prevented trabecular microarchitecture impairment in ovariectomized (OVX) mice C57BL/6J, compared to OVX control animals and thatPSO inhibited pro-inflammatory factors expression while stimulating anti-inflammatory ones.
Abstract: In the current context of longer life expectancy, the prevalence of osteoporosis is increasingly important. This is why development of new strategies of prevention is highly suitable. Pomegranate seed oil (PSO) and its major component, punicic acid (a conjugated linolenic acid), have potent anti-inflammatory and anti-oxidative properties both in vitro and in vivo, two processes strongly involved in osteoporosis establishment. In this study, we demonstrated that PSO consumption (5% of the diet) improved significantly bone mineral density (240.24±11.85 vs. 203.04±34.19 mg/cm(3)) and prevented trabecular microarchitecture impairment in ovariectomized (OVX) mice C57BL/6J, compared to OVX control animals. Those findings are associated with transcriptional changes in bone tissue, suggesting involvement of both osteoclastogenesis inhibition and osteoblastogenesis improvement. In addition, thanks to an ex vivo experiment, we provided evidence that serum from mice fed PSO (5% by gavage) had the ability to significantly down-regulate the expression of specific osteoclast differentiation markers and RANK-RANKL downstream signaling targets in osteoclast-like cells (RAW264.7) (RANK: negative 0.49-fold vs. control conditions). Moreover, in osteoblast-like cells (MC3T3-E1), it elicited significant increase in alkaline phosphatase activity (+159% at day 7), matrix mineralization (+271% on day 21) and transcriptional levels of major osteoblast lineage markers involving the Wnt/β-catenin signaling pathways. Our data also reveal that PSO inhibited pro-inflammatory factors expression while stimulating anti-inflammatory ones. These results demonstrate that PSO is highly relevant regarding osteoporosis. Indeed, it offers promising alternatives in the design of new strategies in nutritional management of age-related bone complications.
42 citations
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TL;DR: In this article, the role of porosity in 3D printed Acrylonitrile Butadiene Styrene (ABS) is studied using X-ray μ-tomography.
41 citations
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TL;DR: It is predicted early after Map introduction in a dairy cattle herd whether infection is likely to fade out or persist, when no control measures are implemented, using a modelling approach and early detection of affected animals is crucial in preventing Map persistence in dairy herds.
Abstract: Epidemiological models enable to better understand the dynamics of infectious diseases and to assess ex-ante control strategies. For Mycobacterium avium subsp. paratuberculosis (Map), possible transmission routes have been described, but Map spread in a herd and the relative importance of the routes are currently insufficiently understood to prioritize control measures. We aim to predict early after Map introduction in a dairy cattle herd whether infection is likely to fade out or persist, when no control measures are implemented, using a modelling approach. Both vertical transmission and horizontal transmission via the ingestion of colostrum, milk, or faeces present in the contaminated environment were modelled. Calf-to-calf indirect transmission was possible. Six health states were represented: susceptible, transiently infectious, latently infected, subclinically infected, clinically affected, and resistant. The model was partially validated by comparing the simulated prevalence with field data. Housing facilities and contacts between animals were specifically considered for calves and heifers. After the introduction of one infected animal in a naive herd, fadeout occurred in 66% of the runs. When Map persisted, the prevalence of infected animals increased to 88% in 25 years. The two main transmission routes were via the farm's environment and in utero transmission. Calf-to-calf transmission was minor. Fadeout versus Map persistence could be differentiated with the number of clinically affected animals, which was rarely above one when fadeout occurred. Therefore, early detection of affected animals is crucial in preventing Map persistence in dairy herds.
41 citations
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TL;DR: The inhibitory effect of water activity and storage temperature on single spore lag times of Aspergillus niger, Eurotium repens and Penicillium corylophilum strains isolated from spoiled bakery products, was quantified and found to be similar to those obtained at the population level, whatever the species.
40 citations
Authors
Showing all 446 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean-Pierre Benoit | 78 | 428 | 22384 |
Denis Jacquemin | 69 | 623 | 22712 |
Olivier Beauchet | 63 | 320 | 13778 |
Dominique Heymann | 62 | 347 | 13497 |
Paul Calès | 61 | 353 | 14123 |
Jérôme Guicheux | 58 | 238 | 9568 |
Ignacio Anegon | 57 | 265 | 11797 |
Cédric Annweiler | 54 | 346 | 9990 |
Michel Neunlist | 53 | 204 | 9136 |
Patrick Saulnier | 50 | 219 | 13125 |
Bruno Le Bizec | 50 | 295 | 9082 |
Alain Mercat | 49 | 142 | 16603 |
Vincent Rohmer | 48 | 121 | 7090 |
J.C. Bernède | 47 | 345 | 7669 |
Jean-Philippe Antignac | 46 | 171 | 6392 |