Université Nantes Angers Le Mans

About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Population. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.

A Physically Based Identification of Vertical Profiles of Reflectivity from Volume Scan Radar Data

Abstract: The vertical profile of reflectivity (VPR) must be identified to correct estimations of rainfall rates by radar for the nonuniform beam filling associated with the vertical variation of radar reflectivity. A method for identifying VPRs from volumetric radar data is presented that takes into account the radar sampling. Physically based constraints on the vertical structure of rainfall are introduced with simple VPR models within a rainfall classification procedure defining more homogeneous precipitation patterns. The model parameters are identified in the framework of an extended Kalman filter to ensure their temporal consistency. The method is assessed using the dataset from a volume-scanning strategy for radar quantitative precipitation estimation designed in 2002 for the Bollene radar (France). The physical consistency of the retrieved VPR is evaluated. Positive results are obtained insofar as the physically based identified VPR (i) presents physically consistent shapes and characteristics consi...

Calibration Adjustment of the Mid-infrared Analyzer for an Accurate Determination of the Macronutrient Composition of Human Milk.

Abstract: Background:Human milk composition analysis seems essential to adapt human milk fortification for preterm neonates. The Miris human milk analyzer (HMA), based on mid-infrared methodology, is conveni...

Time window-dependent effect of perinatal maternal protein restriction on insulin sensitivity and energy substrate oxidation in adult male offspring

Abstract: Epidemiological and experimental evidence suggests that a suboptimal environment during perinatal life programs offspring susceptibility to the development of metabolic syndrome and Type 2 diabetes. We hypothesized that the lasting impact of perinatal protein deprivation on mitochondrial fuel oxidation and insulin sensitivity would depend on the time window of exposure. To improve our understanding of underlying mechanisms, an integrative approach was used, combining the assessment of insulin sensitivity and untargeted mass spectrometry-based metabolomics in the offspring. A hyperinsulinemic-euglycemic clamp was performed in adult male rats born from dams fed a low-protein diet during gestation and/or lactation, and subsequently exposed to a Western diet (WD) for 10 wk. Metabolomics was combined with targeted acylcarnitine profiling and analysis of liver gene expression to identify markers of adaptation to WD that influence the phenotype outcome evaluated by body composition analysis. At adulthood, offspring of protein-restricted dams had impaired insulin secretion when fed a standard diet. Moreover, rats who demonstrated catch-up growth at weaning displayed higher gluconeogenesis and branched-chain amino acid catabolism, and lower fatty acid β-oxidation compared with control rats. Postweaning exposure of intrauterine growth restriction-born rats to a WD exacerbated incomplete fatty acid β-oxidation and excess fat deposition. Control offspring nursed by protein-restricted mothers showed peculiar low-fat accretion through adulthood and preserved insulin sensitivity even after WD-exposure. Altogether, our findings suggest a testable hypothesis about how maternal diet might influence metabolic outcomes (insulin sensitivity) in the next generation such as mitochondrial overload and/or substrate oxidation inflexibility dependent on the time window of perinatal dietary manipulation.