Institution
Université Nantes Angers Le Mans
Education•Nantes, France•
About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Finite element method. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.
Topics: Geology, Finite element method, Population, Mars Exploration Program, Ultimate tensile strength
Papers
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TL;DR: In this article, a meso-scale analysis is performed to study the size effect on the nominal stress at failure and quantify the evolution of the fracture process zone (FPZ) in the context of the tensile splitting test.
30 citations
TL;DR: A deterministic mathematical model accounting for the seasonality in vector abundance and all the modes of transmission for Bluetongue virus serotype 8 was built and almost perfect vaccine efficacy and coverage were required to ensure no epidemics occurred.
29 citations
TL;DR: In this article, the effect of the amount of steam injection on selected bread characteristics was investigated using a deck oven (1.m 2 internal surface) for 20min with steaming of 100, 200, 300, 400 and 500 ml.
29 citations
TL;DR: Control of HO-1 expression may be of great interest in immune intervention protocols where tolerance is desirable, such as in transplantation, or where enhanced immunogenicity is needed in the case of cancer.
Abstract: Heme oxygenases (HOs) are the rate-limiting intracellular enzymes that degrade heme into carbon monoxide (CO), biliverdin and free divalent iron. Among HOs, HO-1 is the only isoform that is highly inducible in response to numerous stress factors and proinflammatory cytokines. This enzyme has shown cytoprotective, antioxidant and anti-inflammatory properties. Moreover, HO-1 and, in particular, CO also have tolerogenic actions in adaptive immune responses. HO-1 can provide immunosuppression through its expression by regulatory T cells or antigen-presenting cells. The physiological importance of HO-1 has been demonstrated in both mice and humans, and modulation of HO-1 expression has therapeutic effects in a variety of disorders involving inflammation and immune responses, including organ transplantation and cancer. Consistently, upregulation of the HO-1 pathway has a significant protective effect against spontaneous or induced autoimmune diseases, allergy and can be beneficial to graft survival. However, HO-1 may also play a role in tumorigenesis by lowering antitumor innate immune responses that control tumor growth or reduce tumor expansion. Thus, controlling HO-1 expression may be of great interest in immune intervention protocols where tolerance is desirable, such as in transplantation, or where enhanced immunogenicity is needed in the case of cancer.
28 citations
TL;DR: Exposure to the BTV-8 virus under natural conditions in previously naive dairy herds notified after clinical suspicion during the 2007 epizootic was associated with an increase in the occurrence of abortions, regardless of the stage of pregnancy.
28 citations
Authors
Showing all 446 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Jean-Pierre Benoit | 78 | 428 | 22384 |
| Denis Jacquemin | 69 | 623 | 22712 |
| Olivier Beauchet | 63 | 320 | 13778 |
| Dominique Heymann | 62 | 347 | 13497 |
| Paul Calès | 61 | 353 | 14123 |
| Jérôme Guicheux | 58 | 238 | 9568 |
| Ignacio Anegon | 57 | 265 | 11797 |
| Cédric Annweiler | 54 | 346 | 9990 |
| Michel Neunlist | 53 | 204 | 9136 |
| Patrick Saulnier | 50 | 219 | 13125 |
| Bruno Le Bizec | 50 | 295 | 9082 |
| Alain Mercat | 49 | 142 | 16603 |
| Vincent Rohmer | 48 | 121 | 7090 |
| J.C. Bernède | 47 | 345 | 7669 |
| Jean-Philippe Antignac | 46 | 171 | 6392 |