Institution
Université Nantes Angers Le Mans
Education•Nantes, France•
About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Population. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.
Papers
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TL;DR: Absence of pulsatility in resistance arteries increased oxidative stress, which in turn induced inflammation and preferentially altered pressure and flow-dependent tone, which play a key role in control of local blood flow.
18 citations
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TL;DR: The average BTV-8 exposure in naïve herds led to major losses and the episode of decreased fertility is likely due to a combination of the effect of the infection at different stages of conception and early pregnancy and the delayed exposure of cows due to the spreading of the virus within herds.
18 citations
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TL;DR: A 5-month-old female Great Dane puppy treated for hematochezia, tenesmus, and rectal prolapse by resection of a 10-cm-long segment of colon and rectum had diffuse mucosal and submucosal thickening with multiple polypoid nodules.
Abstract: A 5-month-old female Great Dane puppy was treated for hematochezia, tenesmus, and rectal prolapse by resection of a 10-cm-long segment of colon and rectum. Grossly, the colorectal segment had diffuse mucosal and submucosal thickening with multiple polypoid nodules. The histologic diagnosis was colorectal hamartomatous polyps with ganglioneuromatosis. Duplication of PTEN was detected by quantitative multiplex polymerase chain reaction testing. The presence of 2 hamartomatous colorectal lesions with PTEN mutation is similar to human Cowden syndrome.
18 citations
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TL;DR: It is demonstrated that erythrocyte invasion by B. divergens is a rapid process since 70% of the invasion-competent parasites invaded the RBC in less than 45 s and despite a synchronous start, the parasite population evolved heterogeneously resulting in a progressive loss of synchronisation.
Abstract: Babesia divergens is a tick-transmitted apicomplexan parasite for which asexual multiplication in its vertebrate hosts is restricted to erythrocytes. Current knowledge of invasion of these target cells is limited. An efficient in vitro invasion assay was set up to gain access to this information. Parasites prepared from infected RBC, lysed by electroporation, and mixed with bovine RBC in a selected synthetic medium (RPMI 1640 supplemented with calcium) were able to establish subsequent cultures with parasitemia ranging from 6 to 14%. Free parasites remaining in the invasion medium could be eliminated by Percoll gradient and culture could be pursued with the freshly invaded erythrocytes. In this way, the invasion time window could be shortened to obtain a synchronised start of the culture or to study the kinetics of invasion. With this assay we demonstrate that 1) erythrocyte invasion by B. divergens is a rapid process since 70% of the invasion-competent parasites invaded the RBC in less than 45 s; 2) all invasion-competent parasites achieved invasion within 10 min of contact; 3) one erythrocyte could be invaded concomitantly by two merozoites; 4) despite a synchronous start, the parasite population evolved heterogeneously resulting in a progressive loss of synchronisation. Western blot analysis of proteins collected from invasion medium were performed with sera from animals experimentally infected with B. divergens and highlighted several proteins. The dose-dependent, inhibitory effects of these sera on B. divergens invasion suggest that these proteins might be involved in the invasion process. Further investigations are required for their characterisation.
18 citations
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TL;DR: The impact of hydrothermal processing undergone by bread dough during baking on the degree of starch granule disruption, on leaching of soluble amylose, on water mobility, on firmness and on amylopectin retrogradation during staling has been investigated.
Abstract: The impact of hydrothermal processing undergone by bread dough during baking on the degree of starch granule disruption, on leaching of soluble amylose, on water mobility, on firmness and on amylopectin retrogradation during staling has been investigated. Two heating rates during baking have been considered (4.67 and 6.31 °C/min) corresponding respectively to baking temperature of 220 and 240 °C. An increase in firmness and in the amount of retrogradated amylopectin accompanied by a decrease in freezable water has been observed during staling. Although a lower heating rate yielded in larger amount of retrogradated amylopectin retrogradation, it resulted in a lower firmness. Additionally, the amount of soluble amylose and the relaxation times of water measured by Nuclear Magnetic Resonance NMR (T20, T21 and T22) decreased during staling. It was demonstrated that the amount of soluble amylose was higher for bread crumb baked at lower heating rate, indicating that an increasing amount of amylose is leached outside the starch granules. This was corresponding to a greater amount of retrograded amylopectin during staling. Moreover, it was found that the degree of gelatinization differs locally in a same bread slice between the top, the centre and the bottom locations in the crumb. This was attributed to the differences in kinetics of heating, the availability of water during baking and the degree of starch granule disruption during baking. Based on first order kinetic model, it was found that staling kinetics were faster for samples baked at higher heating rate.
18 citations
Authors
Showing all 446 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean-Pierre Benoit | 78 | 428 | 22384 |
Denis Jacquemin | 69 | 623 | 22712 |
Olivier Beauchet | 63 | 320 | 13778 |
Dominique Heymann | 62 | 347 | 13497 |
Paul Calès | 61 | 353 | 14123 |
Jérôme Guicheux | 58 | 238 | 9568 |
Ignacio Anegon | 57 | 265 | 11797 |
Cédric Annweiler | 54 | 346 | 9990 |
Michel Neunlist | 53 | 204 | 9136 |
Patrick Saulnier | 50 | 219 | 13125 |
Bruno Le Bizec | 50 | 295 | 9082 |
Alain Mercat | 49 | 142 | 16603 |
Vincent Rohmer | 48 | 121 | 7090 |
J.C. Bernède | 47 | 345 | 7669 |
Jean-Philippe Antignac | 46 | 171 | 6392 |