Institution
Université Nantes Angers Le Mans
Education•Nantes, France•
About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Population. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.
Papers
More filters
••
TL;DR: In this paper, a cross-calibration method is proposed, which aims at both selecting the best candidate sensors and improving the furnished raw data, based upon four steps: (i) an outlier detection, (ii) the crowd sensorsbased correction, (iii) a fixed sensors-based correction and (iv) the L den estimation.
16 citations
••
TL;DR: IGF1R overexpression is common and related to a poor outcome in canine invasive mammary carcinoma, particularly in the triple negative subtype, as in human breast cancer.
Abstract: Dogs spontaneously develop invasive mammary carcinoma with a high prevalence of the triple-negative (TN) subtype (lack of ER-Estrogen Receptor and PR-Progesterone Receptor expression, lack of HER2-Human Epidermal Growth Factor Receptor 2 overexpression), making this animal model relevant for investigating new therapeutic pathways. Insulin-like growth factor Type-1 receptor (IGF1R) is frequently overexpressed in primary human breast cancers, with a growing role in the TN phenotype. The purpose of this study was to investigate the Dog as a candidate model for IGF1R-overexpressing mammary carcinoma. 150 bitches with canine mammary carcinoma (CMC) and a known 2-year follow-up were retrospectively included. IGF1R expression was assessed by immunohistochemistry (IHC) using a similar scoring system as for HER2 in breast cancer. The prognostic value of the IGF1R expression was assessed in terms of overall and specific survival as well as disease-free interval (DFI). 47 CMC (31 %) were classified as luminal and 103 (69 %) as triple-negative (TN-CMC). 41 % of CMC overexpressed IGF1R (IHC score 3+) of which 76 % were TN-CMC and 62 % grade III. IGF1R overexpression was associated with aggressive features including lymphovascular invasion, histological grade III, low ER expression and the TN phenotype. Univariate and multivariate analyses revealed that IGF1R overexpression was associated with shorter overall and specific survivals and shorter DFI in TN-CMC. IGF1R overexpression is common and related to a poor outcome in canine invasive mammary carcinoma, particularly in the triple negative subtype, as in human breast cancer. Preclinical studies using the Dog as a spontaneous animal model could be considered to investigate new therapies targeting IGF1R in triple-negative breast cancer.
15 citations
••
TL;DR: It is shown that the NFL‐TBS.40‐63 peptide, corresponding to the sequence of a tubulin‐binding site on neurofilaments, can target glioblastoma cells, where it disrupts their microtubules and inhibits their proliferation.
Abstract: UNLABELLED Targeting neural stem cells (NSCs) in the adult brain represents a promising approach for developing new regenerative strategies, because these cells can proliferate, self-renew, and differentiate into new neurons, astrocytes, and oligodendrocytes. Previous work showed that the NFL-TBS.40-63 peptide, corresponding to the sequence of a tubulin-binding site on neurofilaments, can target glioblastoma cells, where it disrupts their microtubules and inhibits their proliferation. We show that this peptide targets NSCs in vitro and in vivo when injected into the cerebrospinal fluid. Although neurosphere formation was not altered by the peptide, the NSC self-renewal capacity and proliferation were reduced and were associated with increased adhesion and differentiation. These results indicate that the NFL-TBS.40-63 peptide represents a new molecular tool to target NSCs to develop new strategies for regenerative medicine and the treatment of brain tumors. SIGNIFICANCE In the present study, the NFL-TBS.40-63 peptide targeted neural stem cells in vitro when isolated from the subventricular zone and in vivo when injected into the cerebrospinal fluid present in the lateral ventricle. The in vitro formation of neurospheres was not altered by the peptide; however, at a high concentration of the peptide, the neural stem cell (NSC) self-renewal capacity and proliferation were reduced and associated with increased adhesion and differentiation. These results indicate that the NFL-TBS.40-63 peptide represents a new molecular tool to target NSCs to develop new strategies for regenerative medicine and the treatment of brain tumors.
15 citations
••
TL;DR: Elderly women with inside falls had shorter survivals than others, which could be markers of an underlying frailty and should trigger adequate prevention and protection measures.
15 citations
••
TL;DR: This study combines experimental and numerical approaches to investigate the microstructure and mechanical behaviour of non-miscible plasticised starch/zein blends and allows detecting the presence of perfect or imperfect interface between starch and zein particles depending on the nature of plasticiser.
15 citations
Authors
Showing all 446 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean-Pierre Benoit | 78 | 428 | 22384 |
Denis Jacquemin | 69 | 623 | 22712 |
Olivier Beauchet | 63 | 320 | 13778 |
Dominique Heymann | 62 | 347 | 13497 |
Paul Calès | 61 | 353 | 14123 |
Jérôme Guicheux | 58 | 238 | 9568 |
Ignacio Anegon | 57 | 265 | 11797 |
Cédric Annweiler | 54 | 346 | 9990 |
Michel Neunlist | 53 | 204 | 9136 |
Patrick Saulnier | 50 | 219 | 13125 |
Bruno Le Bizec | 50 | 295 | 9082 |
Alain Mercat | 49 | 142 | 16603 |
Vincent Rohmer | 48 | 121 | 7090 |
J.C. Bernède | 47 | 345 | 7669 |
Jean-Philippe Antignac | 46 | 171 | 6392 |