Université Nantes Angers Le Mans

About: Université Nantes Angers Le Mans is a education organization based out in Nantes, France. It is known for research contribution in the topics: Geology & Finite element method. The organization has 434 authors who have published 249 publications receiving 7208 citations. The organization is also known as: PRES Universite Nantes Angers Le Mans.

Waldenström's macroglobulinemia in a dog with a bleeding diathesis

Abstract: An 11-year-old female spayed Whippet dog was referred to the Veterinary Hospital of the National Veterinary School of Lyon with a 3-month history of chronic bleeding, cutaneous masses suggestive of hematomas, and hemorrhagic diarrhea. Laboratory abnormalities included leukopenia with neutropenia and lymphopenia, rouleaux formation, marked hyperproteinemia with hyperglobulinemia and normoalbuminemia, hypercalcemia, markedly increased serum urea concentration, mildly increased creatinine concentration, and proteinuria. Hemostatic screening tests showed marked prolongation of thrombin time, increased concentrations of fibrin(ogen) degradation products and D-dimers, and slightly prolonged activated partial thromboplastin time. Serum and urine protein electrophoresis revealed a monoclonal peak identified as IgM by immunoelectrophoresis and an M-spike, respectively. Cytologic evaluation of bone marrow revealed a hypocellular sample with lymphoplasmacytic cells comprising approximately 50% of all nucleated cells. These findings were consistent with a diagnosis of Waldenstrom's macroglobulinemia with secondary bleeding diathesis. Treatment with prednisone and chlorambucil was initiated, and the dog had a good response.

Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism (vol 115, pg E715, 2018)

Abstract: Danish Headache Center, Department of Neurology, Rigshospitalet, University of Copenhagen, 1165 Copenhagen, Denmark; Université de Rennes I, Inserm, EHESP-School of Public Health, Irset (Institut de Recherche en Santé, Environnement et Travail) UMR_S 1085, F-35000 Rennes, France; Novo Nordisk Foundation Center for Protein Research Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3A, 2200 Copenhagen, Denmark; Institute of Sports Medicine, Department of Orthopaedic Surgery M, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark; Center for Healthy Aging, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark; DTU Bio and Health Informatics, Technical University of Denmark, 2800 Kongens Lyngby, Denmark; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark; L’Université Nantes Angers Le Mans (LUNAM), Oniris, UMR 1329 INRA Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), F-44307 Nantes, France; Unité de coordination hospitalière des prélèvements d’organes et de tissus, Centre Hospitalier Universitaire de Rennes, 35000 Rennes, France; Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 1165 Copenhagen, Denmark; Department of Environmental Medicine, University of Southern Denmark, 5000 Odense, Denmark; Department of Biology, Faculty of Science, University of Copenhagen, 2100 Copenhagen, Denmark; Institute of Metagenomics, BGI-Shenzhen, Shenzhen 518083, China; Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark; and EDMaRC (International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health), Rigshospitalet, University of Copenhagen, DK-2200 Copenhagen, Denmark

Structural and dynamic properties of aluminosilicate melts: a molecular dynamics study.

Abstract: In the present work, the structural and dynamic properties of aluminosilicates (Al2O3) x -(SiO2)1-x (AS) as a function of the Al2O3 concentration x are studied by means of molecular dynamics simulations. Firstly, the parametrization of the Born-Mayer-Huggins type potential developed recently for the more general CaO-Al2O3-SiO2 ternary system is assessed. Comparison of local structural properties, such as the x-ray structure factor, partial pair-correlation functions, distributions of coordination numbers and bond angles, as well as the dynamics through the viscosity and self-diffusion coefficients to experimental data and other molecular dynamics simulations found in the literature, shows that this potential is transferable to AS melts for all compositions and is more reliable than other empirical potentials used so far. The evolution of viscosity with temperature in stable liquid and undercooled regions is studied in the whole composition range and results show a progressive increase of the fragility with increasing Al2O3 content correlated to that of local structural entities like the triply bonded oxygen (TBO), AlO5 and AlO6.