Showing papers by "Université Paris-Saclay published in 2012"
Tohoku University1, University of Zurich2, Lawrence Berkeley National Laboratory3, Stanford University4, College of William & Mary5, University of Genoa6, University of Urbino7, CERN8, Budker Institute of Nuclear Physics9, University of California, Irvine10, Cornell University11, Argonne National Laboratory12, ETH Zurich13, Tata Institute of Fundamental Research14, Hillsdale College15, Spanish National Research Council16, Ohio State University17, University of Notre Dame18, Kent State University19, University of California, San Diego20, University of California, Berkeley21, University of Minnesota22, University of Alabama23, University of Helsinki24, Los Alamos National Laboratory25, California Institute of Technology26, George Washington University27, Syracuse University28, Lawrence Livermore National Laboratory29, Oklahoma State University–Stillwater30, University of Washington31, Max Planck Society32, Boston University33, University of California, Los Angeles34, Royal Holloway, University of London35, Université Paris-Saclay36, Fermilab37, University of Pennsylvania38, University of Illinois at Urbana–Champaign39, University of Bristol40, University of Tokyo41, University of Delaware42, Carnegie Mellon University43, University of California, Santa Cruz44, Karlsruhe Institute of Technology45, Heidelberg University46, Florida State University47, Carleton University48, University of Mainz49, University of Edinburgh50, Brookhaven National Laboratory51, Durham University52, University of Lausanne53, Massachusetts Institute of Technology54, University of Southampton55, Nagoya University56, University of Oxford57, Northwestern University58, University of British Columbia59, Columbia University60, Lund University61, University of Sheffield62, University of California, Santa Barbara63, Iowa State University64, University of Alberta65, University of Cambridge66
TL;DR: The Particle Data Group's biennial review as mentioned in this paper summarizes much of particle physics, using data from previous editions, plus 2658 new measurements from 644 papers, and lists, evaluates, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons.
Abstract: This biennial Review summarizes much of particle physics. Using data from previous editions, plus 2658 new measurements from 644 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors, probability, and statistics. Among the 112 reviews are many that are new or heavily revised including those on Heavy-Quark and Soft-Collinear Effective Theory, Neutrino Cross Section Measurements, Monte Carlo Event Generators, Lattice QCD, Heavy Quarkonium Spectroscopy, Top Quark, Dark Matter, V-cb & V-ub, Quantum Chromodynamics, High-Energy Collider Parameters, Astrophysical Constants, Cosmological Parameters, and Dark Matter. A booklet is available containing the Summary Tables and abbreviated versions of some of the other sections of this full Review. All tables, listings, and reviews (and errata) are also available on the Particle Data Group website: http://pdg.lbl.gov.
4,465 citations
Daniel J. Klionsky1, Fábio Camargo Abdalla2, Hagai Abeliovich3, Robert T. Abraham4 +1284 more•Institutions (463)
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Abstract: In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
4,316 citations
TL;DR: A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
Abstract: To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.
786 citations
University of Potsdam1, Université Paris-Saclay2, Purdue University3, Japan Agency for Marine-Earth Science and Technology4, University of California, Berkeley5, University of Southern California6, Pennsylvania State University7, Northwestern University8, Columbia University9, University of Nantes10, University of Washington11, Technische Universität München12, California Institute of Technology13, University of Colorado Boulder14, Texas A&M University15, ETH Zurich16
TL;DR: In this paper, the authors review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids from photosynthesizing organisms, and provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities.
Abstract: Hydrogen-isotopic abundances of lipid biomarkers are emerging as important proxies in the study of ancient environments and ecosystems. A decade ago, pioneering studies made use of new analytical methods and demonstrated that the hydrogen-isotopic composition of individual lipids from aquatic and terrestrial organisms can be related to the composition of their growth (i.e., environmental) water. Subsequently, compound-specific deuterium/hydrogen (D/H) ratios of sedimentary biomarkers have been increasingly used as paleohydrological proxies over a range of geological timescales. Isotopic fractionation observed between hydrogen in environmental water and hydrogen in lipids, however, is sensitive to biochemical, physiological, and environmental influences on the composition of hydrogen available for biosynthesis in cells. Here we review the factors and processes that are known to influence the hydrogen-isotopic compositions of lipids-especially n-alkanes-from photosynthesizing organisms, and we provide a framework for interpreting their D/H ratios from ancient sediments and identify future research opportunities.
740 citations
TL;DR: In this article, the BaBar data sample was used to investigate the sensitivity of BaBar ratios to new physics contributions in the form of a charged Higgs boson in the type II two-Higgs doublet model.
Abstract: Based on the full BaBar data sample, we report improved measurements of the ratios R(D(*)) = B(B -> D(*) Tau Nu)/B(B -> D(*) l Nu), where l is either e or mu. These ratios are sensitive to new physics contributions in the form of a charged Higgs boson. We measure R(D) = 0.440 +- 0.058 +- 0.042 and R(D*) = 0.332 +- 0.024 +- 0.018, which exceed the Standard Model expectations by 2.0 sigma and 2.7 sigma, respectively. Taken together, our results disagree with these expectations at the 3.4 sigma level. This excess cannot be explained by a charged Higgs boson in the type II two-Higgs-doublet model. We also report the observation of the decay B -> D Tau Nu, with a significance of 6.8 sigma.
660 citations
TL;DR: In this article, the performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at the LHC in 2010.
Abstract: The performance of muon reconstruction, identification, and triggering in CMS has been studied using 40 inverse picobarns of data collected in pp collisions at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection criteria covering a wide range of physics analysis needs have been examined. For all considered selections, the efficiency to reconstruct and identify a muon with a transverse momentum pT larger than a few GeV is above 95% over the whole region of pseudorapidity covered by the CMS muon system, abs(eta)<2.4, while the probability to misidentify a hadron as a muon is well below 1%. The efficiency to trigger on single muons with pT above a few GeV is higher than 90% over the full eta range, and typically substantially better. The overall momentum scale is measured to a precision of 0.2% with muons from Z decays. The transverse momentum resolution varies from 1% to 6% depending on pseudorapidity for muons with pT below 100 GeV and, using cosmic rays, it is shown to be better than 10% in the central region up to pT = 1 TeV. Observed distributions of all quantities are well reproduced by the Monte Carlo simulation.
568 citations
TL;DR: A meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease identifies novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
Abstract: Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.
456 citations
TL;DR: In this paper, a Fourier analysis of the charged particle pair distribution in relative azimuthal angle (Delta phi = phi(a)-phi(b)) is performed to extract the coefficients v(n,n) =.
Abstract: Differential measurements of charged particle azimuthal anisotropy are presented for lead-lead collisions at root sNN = 2.76 TeV with the ATLAS detector at the LHC, based on an integrated luminosity of approximately 8 mu b(-1). This anisotropy is characterized via a Fourier expansion of the distribution of charged particles in azimuthal angle relative to the reaction plane, with the coefficients v(n) denoting the magnitude of the anisotropy. Significant v(2)-v(6) values are obtained as a function of transverse momentum (0.5 = 3 are found to vary weakly with both eta and centrality, and their p(T) dependencies are found to follow an approximate scaling relation, v(n)(1/n)(p(T)) proportional to v(2)(1/2)(p(T)), except in the top 5% most central collisions. A Fourier analysis of the charged particle pair distribution in relative azimuthal angle (Delta phi = phi(a)-phi(b)) is performed to extract the coefficients v(n,n) = . For pairs of charged particles with a large pseudorapidity gap (|Delta eta = eta(a) - eta(b)| > 2) and one particle with p(T) < 3 GeV, the v(2,2)-v(6,6) values are found to factorize as v(n,n)(p(T)(a), p(T)(b)) approximate to v(n) (p(T)(a))v(n)(p(T)(b)) in central and midcentral events. Such factorization suggests that these values of v(2,2)-v(6,6) are primarily attributable to the response of the created matter to the fluctuations in the geometry of the initial state. A detailed study shows that the v(1,1)(p(T)(a), p(T)(b)) data are consistent with the combined contributions from a rapidity-even v(1) and global momentum conservation. A two-component fit is used to extract the v(1) contribution. The extracted v(1) isobserved to cross zero at pT approximate to 1.0 GeV, reaches a maximum at 4-5 GeV with a value comparable to that for v(3), and decreases at higher p(T).
435 citations
Institut d'Astrophysique de Paris1, University of Chile2, Lawrence Berkeley National Laboratory3, University of Wyoming4, Max Planck Society5, Princeton University6, University of Washington7, New Mexico State University8, University of Utah9, Pennsylvania State University10, Tel Aviv University11, University of Florida12, Carnegie Mellon University13, Université Paris-Saclay14, Harvard University15, Yale University16, University of Arizona17, Erciyes University18, University of Zurich19, York University20, New York University21, National Radio Astronomy Observatory22, University of California, Irvine23, University of Portsmouth24, University of Cambridge25, University of La Laguna26, Spanish National Research Council27, Drexel University28, Brookhaven National Laboratory29, University of California, Berkeley30, Ohio State University31, University of Pittsburgh32
TL;DR: The Data Release 9 Quasar (DR9Q) catalog from the Baryon Oscillation Spectroscopic Survey (BOSS) of the Sloan Digital Sky Survey (III) is presented in this article.
Abstract: We present the Data Release 9 Quasar (DR9Q) catalog from the Baryon Oscillation Spectroscopic Survey (BOSS) of the Sloan Digital Sky Survey III. The catalog includes all BOSS objects that were targeted as quasar candidates during the survey, are spectrocopically confirmed as quasars via visual inspection, have luminosities M i [z = 2] 0 = 70 km s-1 Mpc-1 , ΩM = 0.3, and ΩΛ = 0.7) and either display at least one emission line with full width at half maximum (FWHM) larger than 500 km s-1 or, if not, have interesting/complex absorption features. It includes as well, known quasars (mostly from SDSS-I and II) that were reobserved by BOSS. This catalog contains 87 822 quasars (78 086 are new discoveries) detected over 3275 deg2 with robust identification and redshift measured by a combination of principal component eigenspectra newly derived from a training set of 8632 spectra from SDSS-DR7. The number of quasars with z > 2.15 (61 931) is ~2.8 times larger than the number of z > 2.15 quasars previously known. Redshifts and FWHMs are provided for the strongest emission lines (C iv, C iii], Mg ii). The catalog identifies 7533 broad absorption line quasars and gives their characteristics. For each object the catalog presents five-band (u , g , r , i , z ) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains X-ray, ultraviolet, near-infrared, and radio emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3600−10 500 A at a spectral resolution in the range 1300 < 2500; the spectra can be retrieved from the SDSS Catalog Archive Server. We also provide a supplemental list of an additional 949 quasars that have been identified, among galaxy targets of the BOSS or among quasar targets after DR9 was frozen.
365 citations
TL;DR: In this paper, the production cross sections of the inclusive Drell-Yan processes W-+/- -> l nu and Z/gamma* -> ll (l = e, mu) are measured in proton-proton collisions at root s = 7 TeV with the ATLAS detector.
Abstract: The production cross sections of the inclusive Drell-Yan processes W-+/- -> l nu and Z/gamma* -> ll (l = e, mu) are measured in proton-proton collisions at root s = 7 TeV with the ATLAS detector. The cross sections are reported integrated over a fiducial kinematic range, extrapolated to the full range, and also evaluated differentially as a function of the W decay lepton pseudorapidity and the Z boson rapidity, respectively. Based on an integrated luminosity of about 35 pb(-1) collected in 2010, the precision of these measurements reaches a few percent. The integrated and the differential W-+/- and Z/gamma* cross sections in the e and mu channels are combined, and compared with perturbative QCD calculations, based on a number of different parton distribution sets available at next-to-next-to-leading order.
250 citations
TL;DR: A measurement of the proton-air cross section for particle production at the center-of-mass energy per nucleon of 57 TeV is reported, derived from the distribution of the depths of shower maxima observed with the Pierre Auger Observatory.
Abstract: We report a measurement of the proton-air cross section for particle production at the center-of-mass energy per nucleon of 57 TeV. This is derived from the distribution of the depths of shower maxima observed with the Pierre Auger Observatory: systematic uncertainties are studied in detail. Analyzing the tail of the distribution of the shower maxima, a proton-air cross section of [505 +/- 22(stat)(-36)(+28)(syst)] mb is found.
Basque Government1, French Institute of Health and Medical Research2, Utrecht University3, Aalborg University4, Université Paris-Saclay5, Umeå University6, Lund University7, Autonomous University of Barcelona8, University of Oxford9, University of Murcia10, University of Naples Federico II11, International Agency for Research on Cancer12, German Cancer Research Center13, Wageningen University and Research Centre14, Imperial College London15
TL;DR: An updated meta-analysis using pooled data from five studies including EPIC-InterAct found that subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.
Abstract: Fruit and vegetable intake (FVI) may reduce the risk of type 2 diabetes (T2D), but the epidemiological evidence is inconclusive. The aim of this study is to examine the prospective association of FVI with T2D and conduct an updated meta-analysis. In the European Prospective Investigation into Cancer-InterAct (EPIC-InterAct) prospective case-cohort study nested within eight European countries, a representative sample of 16 154 participants and 12 403 incident cases of T2D were identified from 340 234 individuals with 3.99 million person-years of follow-up. For the meta-analysis we identified prospective studies on FVI and T2D risk by systematic searches of MEDLINE and EMBASE until April 2011. In EPIC-InterAct, estimated FVI by dietary questionnaires varied more than twofold between countries. In adjusted analyses the hazard ratio (95% confidence interval) comparing the highest with lowest quartile of reported intake was 0.90 (0.80-1.01) for FVI; 0.89 (0.76-1.04) for fruit and 0.94 (0.84-1.05) for vegetables. Among FV subtypes, only root vegetables were inversely associated with diabetes 0.87 (0.77-0.99). In meta-analysis using pooled data from five studies including EPIC-InterAct, comparing the highest with lowest category for FVI was associated with a lower relative risk of diabetes (0.93 (0.87-1.00)). Fruit or vegetables separately were not associated with diabetes. Among FV subtypes, only green leafy vegetable (GLV) intake (relative risk: 0.84 (0.74-0.94)) was inversely associated with diabetes. Subtypes of vegetables, such as root vegetables or GLVs may be beneficial for the prevention of diabetes, while total FVI may exert a weaker overall effect.
Northern Arizona University1, Oak Ridge National Laboratory2, Carnegie Institution for Science3, Joint Global Change Research Institute4, University of Colorado Boulder5, National Oceanic and Atmospheric Administration6, Colorado State University7, University of Toronto8, Pennsylvania State University9, University of Illinois at Urbana–Champaign10, University of Alaska Fairbanks11, University of Utah12, Ames Research Center13, Université Paris-Saclay14, Natural Resources Canada15, Auburn University16, Max Planck Society17, University of New Hampshire18, Beijing Normal University19, University of Maryland, College Park20, University of Montana21
TL;DR: In this article, the results from the terrestrial biosphere models collected as part of the regional and continental interim synthesis (RCIS) activities are compared and evaluated over different spatial (1{sup o} x 1{sup O} and spatially aggregated to different regions) and temporal (monthly and annually) scales.
Umeå University1, Charité2, Université Paris-Saclay3, University of Paris-Sud4, Utrecht University5, French Institute of Health and Medical Research6, University of Oxford7, German Cancer Research Center8, University of Cambridge9, University of Naples Federico II10, Imperial College London11, Lund University12, International Agency for Research on Cancer13, Wageningen University and Research Centre14
TL;DR: A collaborative re-analysis of data from the InterAct case-control study has established that waist circumference is associated with risk of type 2 diabetes, independently of body mass index.
Abstract: Background: Waist circumference (WC) is a simple and reliable measure of fat distribution that may add to the prediction of type 2 diabetes (T2D), but previous studies have been too small to reliably quantify the relative and absolute risk of future diabetes by WC at different levels of body mass index (BMI). Methods and Findings: The prospective InterAct case-cohort study was conducted in 26 centres in eight European countries and consists of 12,403 incident T2D cases and a stratified subcohort of 16,154 individuals from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. We used Prentice-weighted Cox regression and random effects meta-analysis methods to estimate hazard ratios for T2D. Kaplan-Meier estimates of the cumulative incidence of T2D were calculated. BMI and WC were each independently associated with T2D, with WC being a stronger risk factor in women than in men. Risk increased across groups defined by BMI and WC; compared to low normal weight individuals (BMI 18.5-22.4 kg/m(2)) with a low WC ( = 35 kg/m(2)) and a high WC (> 102/88 cm). Among the large group of overweight individuals, WC measurement was highly informative and facilitated the identification of a subgroup of overweight people with high WC whose 10-y T2D cumulative incidence (men, 70 per 1,000 person-years; women, 44 per 1,000 person-years) was comparable to that of the obese group (50-103 per 1,000 person-years in men and 28-74 per 1,000 person-years in women). Conclusions: WC is independently and strongly associated with T2D, particularly in women, and should be more widely measured for risk stratification. If targeted measurement is necessary for reasons of resource scarcity, measuring WC in overweight individuals may be an effective strategy, since it identifies a high-risk subgroup of individuals who could benefit from individualised preventive action.
TL;DR: In this paper, the Fermilab staff and technical staff of the participating institutions for their vital contributions and acknowledgment support from the DOE and NSF (USA), ARC and ARC======(Australia), CNPq, FAPERJ, FAPEESP, and FUNDUNESP======
Abstract: We thank the Fermilab staff and technical staffs of the
participating institutions for their vital contributions and
acknowledge support from the DOE and NSF (USA), ARC
(Australia), CNPq, FAPERJ, FAPESP, and FUNDUNESP
(Brazil), NSERC (Canada), NSC, CAS, and CNSF
(China), Colciencias (Colombia), MSMT and GACR
(Czech Republic), the Academy of Finland, CEA, and
CNRS/IN2P3 (France), BMBF and DFG (Germany),
DAE and DST (India), SFI (Ireland), INFN (Italy),
MEXT (Japan), the Korean World Class University
Program and NRF (Korea), CONACyT (Mexico), FOM
(Netherlands), MON, NRC KI, and RFBR (Russia), the
Slovak R&D Agency, the Ministerio de Ciencia e
Innovacio´n, and Programa Consolider-Ingenio 2010
(Spain), The Swedish Research Council (Sweden), SNSF
(Switzerland), STFC and the Royal Society (United
Kingdom), and the A. P. Sloan Foundation (USA).
TL;DR: The first single-shot images of ferromagnetic, nanoscale spin order taken with femtosecond x-ray pulses are presented, opening new ways to combine ultrafast laser spectroscopy with sequential snapshot imaging on a single sample, generating a movie of excited state dynamics.
Abstract: We present the first single-shot images of ferromagnetic, nanoscale spin order taken with femtosecond x-ray pulses. X-ray-induced electron and spin dynamics can be outrun with pulses shorter than 80 fs in the investigated fluence regime, and no permanent aftereffects in the samples are observed below a fluence of 25 mJ/cm{sup 2}. Employing resonant spatially-muliplexed x-ray holography results in a low imaging threshold of 5 mJ/cm{sup 2}. Our results open new ways to combine ultrafast laser spectroscopy with sequential snapshot imaging on a single sample, generating a movie of excited state dynamics.
Medical University of Vienna1, University of Utah2, Heidelberg University3, Université libre de Bruxelles4, Harvard University5, Gdańsk Medical University6, Université Paris-Saclay7, Ludwig Maximilian University of Munich8, Mayo Clinic9, Katholieke Universiteit Leuven10, Johns Hopkins University11, Stanford University12, University of Bern13, National Institutes of Health14
TL;DR: Current concepts in the pathogenesis and evolution of eos inophilia and eosinophil-related organ damage in neoplastic and non-neoplastic conditions are reviewed.
Abstract: Eosinophils and their products play an essential role in the pathogenesis of various reactive and neoplastic disorders. Depending on the underlying disease, molecular defect and involved cytokines, hypereosinophilia may develop and may lead to organ damage. In other patients, persistent eosinophilia is accompanied by typical clinical findings, but the causative role and impact of eosinophilia remain uncertain. For patients with eosinophil-mediated organ pathology, early therapeutic intervention with agents reducing eosinophil counts can be effective in limiting or preventing irreversible organ damage. Therefore, it is important to approach eosinophil disorders and related syndromes early by using established criteria, to perform all appropriate staging investigations, and to search for molecular targets of therapy. In this article, we review current concepts in the pathogenesis and evolution of eosinophilia and eosinophil-related organ damage in neoplastic and non-neoplastic conditions. In addition, we discuss classifications of eosinophil disorders and related syndromes as well as diagnostic algorithms and standard treatment for various eosinophil-related disorders.
Imperial College London1, Aarhus University2, French Institute of Health and Medical Research3, Université Paris-Saclay4, German Cancer Research Center5, National and Kapodistrian University of Athens6, Harvard University7, Academy of Athens8, University of Naples Federico II9, Utrecht University10, Radboud University Nijmegen11, University of Tromsø12, Lund University13, Umeå University14, University of Oxford15, University of Cambridge16, Medical Research Council17, International Agency for Research on Cancer18, University of London19
TL;DR: Higher fiber intake is associated with lower mortality, particularly from circulatory, digestive, and non-CVD noncancer inflammatory diseases, and current recommendations of high dietary fiber intake for health maintenance are supported.
TL;DR: In this paper, the transition helicity amplitudes from the proton ground state to the excited states were determined from the analysis of nine independent one-fold differential electroproduction cross sections off a proton target.
Abstract: The transition helicity amplitudes from the proton ground state to the $$P_{11}(1440)$$ and $$D_{13}(1520)$$ excited states ($$\gamma_{v}pN^*$$ electrocouplings) were determined from the analysis of nine independent one-fold differential $$\pi^{+} \pi^{-} p$$ electroproduction cross sections off a proton target, taken with CLAS at photon virtualities 0.25\enskip {\rm GeV$$^{2}$$} $<$ $$Q^{2}$$ $<$$ 0.60 \enskip {\rm GeV$$^{2}$}. The phenomenological reaction model was employed for separation of the resonant and non-resonant contributions to the final state. The $$P_{11}(1440)$$ and $$D_{13}(1520)$$ electrocouplings were obtained from the resonant amplitudes parametrized within the framework of a unitarized Breit-Wigner ansatz. They are consistent with results obtained in the previous CLAS analyses of the $$\pi^+n$$ and $$\pi^0p$$ channels. The successful description of a large body of data in dominant meson-electroproduction channels off protons with the same $$\gamma_{v}pN^*$$ electrocouplings offers clear evidence for the reliable extraction of these fundamental quantities from meson-electroproduction data. This analysis also led to the determination of the long-awaited hadronic branching ratios for the $$D_{13}(1520)$$ decay into $$\Delta\pi$$ (24%-32%) and $$N\rho$$ (8%-17%).
TL;DR: Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.
Abstract: Sleep problems are highly prevalent in cancer patients undergoing chemotherapy. This article reviews existing evidence on etiology, associated symptoms, and management of sleep problems associated with chemotherapy treatment during cancer. It also discusses limitations and methodological issues of current research. The existing literature suggests that subjectively and objectively measured sleep problems are the highest during the chemotherapy phase of cancer treatments. A possibly involved mechanism reviewed here includes the rise in the circulating proinflammatory cytokines and the associated disruption in circadian rhythm in the development and maintenance of sleep dysregulation in cancer patients during chemotherapy. Various approaches to the management of sleep problems during chemotherapy are discussed with behavioral intervention showing promise. Exercise, including yoga, also appear to be effective and safe at least for subclinical levels of sleep problems in cancer patients. Numerous challenges are associated with conducting research on sleep in cancer patients during chemotherapy treatments and they are discussed in this review. Dedicated intervention trials, methodologically sound and sufficiently powered, are needed to test current and novel treatments of sleep problems in cancer patients receiving chemotherapy. Optimal management of sleep problems in patients with cancer receiving treatment may improve not only the well-being of patients, but also their prognosis given the emerging experimental and clinical evidence suggesting that sleep disruption might adversely impact treatment and recovery from cancer.
TL;DR: In this paper, the authors studied the process e +e −→J/ψπ +π - with initial-state-radiation events produced at the PEP-II asymmetric-energy collider.
Abstract: We study the process e +e -→J/ψπ +π - with initial-state-radiation events produced at the PEP-II asymmetric-energy collider. The data were recorded with the BABAR detector at center-of-mass energies 10.58 and 10.54 GeV, and correspond to an integrated luminosity of 454fb -1. We investigate the J/ψπ +π - mass distribution in the region from 3.5 to 5.5GeV/c2. Below 3.7GeV/c2 the ψ(2S) signal dominates, and above 4GeV/c2 there is a significant peak due to the Y(4260). A fit to the data in the range 3.74-5.50GeV/c2 yields a mass value 4245±5(stat)±4(syst)MeV/c2 and a width value 114-15+16(stat) ±7(syst)MeV for this state. We do not confirm the report from the Belle Collaboration of a broad structure at 4.01GeV/c2. In addition, we investigate the π +π - system which results from Y(4260) decay. © 2012 American Physical Society.
TL;DR: In this article, an updated measurement of the CP-violating phase, ϕsJ/ψϕ, and the decay width difference for the two mass eigenstates, ΔΓs, from the flavor-tagged decay Bs0→J/πϕ was reported.
Abstract: We report an updated measurement of the CP-violating phase, ϕsJ/ψϕ, and the decay-width difference for the two mass eigenstates, ΔΓs, from the flavor-tagged decay Bs0→J/ψϕ. The data sample correspo ...
TL;DR: In this paper, the photon spectrum in the inclusive electromagnetic radiative decays of the B meson was studied using a data sample of (382.8±4.2)×10^6Υ(4S) → BB decays collected by the BABAR experiment at SLAC.
Abstract: The photon spectrum in the inclusive electromagnetic radiative decays of the B meson, B → X_sγ plus B → X_dγ, is studied using a data sample of (382.8±4.2)×10^6Υ(4S) → BB decays collected by the BABAR experiment at SLAC. The spectrum is used to extract the branching fraction B(B → X_sγ)=(3.21±0.33)×10^(-4) for E_γ > 1.8 GeV and the direct CP asymmetry A_(CP)(B → X_(s+d)γ)=0.057±0.063. The effects of detector resolution and Doppler smearing are unfolded to measure the photon energy spectrum in the B meson rest frame.
TL;DR: This approach transforms genetic screens in mice, establishes a general strategy for analysing rare DNA variants and opens up a large new source for experimental models of human disease.
Abstract: Accurate identification of sparse heterozygous single-nucleotide variants (SNVs) is a critical challenge for identifying the causative mutations in mouse genetic screens, human genetic diseases and cancer. When seeking to identify causal DNA variants that occur at such low rates, they are overwhelmed by false-positive calls that arise from a range of technical and biological sources. We describe a strategy using whole-exome capture, massively parallel DNA sequencing and computational analysis, which identifies with a low false-positive rate the majority of heterozygous and homozygous SNVs arising de novo with a frequency of one nucleotide substitution per megabase in progeny of N-ethyl-N-nitrosourea (ENU)-mutated C57BL/6j mice. We found that by applying a strategy of filtering raw SNV calls against known and platform-specific variants we could call true SNVs with a false-positive rate of 19.4 per cent and an estimated false-negative rate of 21.3 per cent. These error rates are small enough to enable calling a causative mutation from both homozygous and heterozygous candidate mutation lists with little or no further experimental validation. The efficacy of this approach is demonstrated by identifying the causative mutation in the Ptprc gene in a lymphocyte-deficient strain and in 11 other strains with immune disorders or obesity, without the need for meiotic mapping. Exome sequencing of first-generation mutant mice revealed hundreds of unphenotyped protein-changing mutations, 52 per cent of which are predicted to be deleterious, which now become available for breeding and experimental analysis. We show that exome sequencing data alone are sufficient to identify induced mutations. This approach transforms genetic screens in mice, establishes a general strategy for analysing rare DNA variants and opens up a large new source for experimental models of human disease.
TL;DR: In this paper, the direct photon nuclear modification factor was calculated as a function of p(T) for different Au + Au collision centralities using the measured p + p direct photon spectrum and compared to theoretical predictions.
Abstract: We report the measurement of direct photons at midrapidity in Au + Au collisions at root s(NN) = 200 GeV. The direct photon signal was extracted for the transverse momentum range of 4 GeV/c < pT < 22 GeV/c, using a statistical method to subtract decay photons from the inclusive photon sample. The direct photon nuclear modification factor R-AA was calculated as a function of p(T) for different Au + Au collision centralities using the measured p + p direct photon spectrum and compared to theoretical predictions. R-AA was found to be consistent with unity for all centralities over the entire measured pT range. Theoretical models that account for modifications of initial direct photon production due to modified parton distribution functions in Au and the different isospin composition of the nuclei predict a modest change of R-AA from unity. They are consistent with the data. Models with compensating effects of the quark-gluon plasma on high-energy photons, such as suppression of jet-fragmentation photons and induced-photon bremsstrahlung from partons traversing the medium, are also consistent with this measurement.
TL;DR: The PHENIX experiment has measured electrons and positrons at midrapidity from the decays of hadrons containing charm and bottom quarks produced in d+Au and p+p collisions, and shows that the mass-dependent Cronin enhancement observed at the Relativistic Heavy Ion Collider extends to the heavy D meson family.
Abstract: The PHENIX experiment has measured electrons and positrons at midrapidity from the decays of hadrons containing charm and bottom quarks produced in d+Au and p+p collisions at sqrt[S(NN)]=200 GeV in the transverse-momentum range 0.85 ≤ p(T)(e) ≤ 8.5 GeV/c. In central d+Au collisions, the nuclear modification factor R(dA) at 1.5
TL;DR: In this paper, the lepton flavor violating decay modes B{sup {+-}} {yields} h{sup{+-} {tau}{ell} (h = K, {pi}; {ell} = e, {mu}) using the BABAR data sample, which corresponds to 472 million B{bar B} pairs.
Abstract: We present a search for the lepton flavor violating decay modes B{sup {+-}} {yields} h{sup {+-}} {tau}{ell} (h = K, {pi}; {ell} = e, {mu}) using the BABAR data sample, which corresponds to 472 million B{bar B} pairs. The search uses events where one B meson is fully reconstructed in one of several hadronic final states. Using the momenta of the reconstructed B, h, and {ell} candidates, we are able to fully determine the {tau} four-momentum. The resulting {tau} candidate mass is our main discriminant against combinatorial background. We see no evidence for B{sup {+-}} {yields} h{sup {+-}} {tau}{ell} decays and set a 90% confidence level upper limit on each branching fraction at the level of a few times 10{sup -5}.
TL;DR: In this article, the fraction of J/psi coming from the feed-down decay of psi' and chi(c) in the midrapidity region (vertical bar y vertical bar < 0: 35) is 9.6 +/- 2.4% and 32 +/- 9%, respectively.
Abstract: We report on charmonium measurements [J/psi (1S), psi' (2S), and chi(c) (1P)] in p + p collisions at root s = 200 GeV. We find that the fraction of J/psi coming from the feed-down decay of psi' and chi(c) in the midrapidity region (vertical bar y vertical bar < 0: 35) is 9.6 +/- 2.4% and 32 +/- 9%, respectively. We also present the p(T) and rapidity dependencies of the J/psi yield measured via dielectron decay at midrapidity (vertical bar y vertical bar < 0.35) and via dimuon decay at forward rapidity (1.2 < vertical bar y vertical bar < 2.2). The statistical precision greatly exceeds that reported in our previous publication [Phys. Rev. Lett. 98, 232002 (2007)]. The new results are compared with other experiments and discussed in the context of current charmonium production models.
TL;DR: In this paper, the authors measured the radiative transition rate of b→sγ with a sum of 38 exclusive final states and found that the inclusive branching fraction with a minimum photon energy of 1.9 GeV is found to be B(B → X_sγ)=(3.29±0.19± 0.48)×10+(-4) where the first uncertainty is statistical and the second is systematic.
Abstract: We use 429 fb^(-1) of e^+e^- collision data collected at the Υ(4S) resonance with the BABAR detector to measure the radiative transition rate of b→sγ with a sum of 38 exclusive final states. The inclusive branching fraction with a minimum photon energy of 1.9 GeV is found to be B(B → X_sγ)=(3.29±0.19±0.48)×10+(-4) where the first uncertainty is statistical and the second is systematic. We also measure the first and second moments of the photon energy spectrum and extract the best-fit values for the heavy-quark parameters, m_b and μ_π^2, in the kinetic and shape function models.
TL;DR: In this article, the authors generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis and chronic urticaria and atopic dermatitis) in order to have a unified definition of severity, control and risk, usable in most situations.
Abstract: Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.