Showing papers by "Université Paris-Saclay published in 2013"
University of California, San Francisco1, Harvard University2, Janssen Pharmaceutica3, University of Texas MD Anderson Cancer Center4, Université Paris-Saclay5, Autonomous University of Barcelona6, Radboud University Nijmegen7, Memorial Sloan Kettering Cancer Center8, Université de Montréal9, Katholieke Universiteit Leuven10, Hamilton Health Sciences11, VU University Amsterdam12, University of Colorado Boulder13, Duke University14, University of Washington15, National and Kapodistrian University of Athens16, University of California, Los Angeles17, University of Western Ontario18
TL;DR: Abiraterone improved radiographic progression-free survival, showed a trend toward improved overall survival, and significantly delayed clinical decline and initiation of chemotherapy in patients with metastatic castration-resistant prostate cancer.
Abstract: A b s t r ac t Background Abiraterone acetate, an androgen biosynthesis inhibitor, improves overall survival in patients with metastatic castration-resistant prostate cancer after chemotherapy. We evaluated this agent in patients who had not received previous chemotherapy. Methods In this double-blind study, we randomly assigned 1088 patients to receive abiraterone acetate (1000 mg) plus prednisone (5 mg twice daily) or placebo plus prednisone. The coprimary end points were radiographic progression-free survival and overall survival. Results The study was unblinded after a planned interim analysis that was performed after 43% of the expected deaths had occurred. The median radiographic progressionfree survival was 16.5 months with abiraterone–prednisone and 8.3 months with prednisone alone (hazard ratio for abiraterone–prednisone vs. prednisone alone, 0.53; 95% confidence interval [CI], 0.45 to 0.62; P<0.001). Over a median follow-up period of 22.2 months, overall survival was improved with abiraterone–prednisone (median not reached, vs. 27.2 months for prednisone alone; hazard ratio, 0.75; 95% CI, 0.61 to 0.93; P = 0.01) but did not cross the efficacy boundary. Abiraterone–predni sone showed superiority over prednisone alone with respect to time to initiation of cytotoxic chemotherapy, opiate use for cancer-related pain, prostate-specific antigen progression, and decline in performance status. Grade 3 or 4 mineralocorticoid-related adverse events and abnormalities on liver-function testing were more common with abiraterone–prednisone. Conclusions Abiraterone improved radiographic progression-free survival, showed a trend toward improved overall survival, and significantly delayed clinical decline and initiation of chemotherapy in patients with metastatic castration-resistant prostate cancer. (Funded by Janssen Research and Development, formerly Cougar Biotechnology; ClinicalTrials.gov number, NCT00887198.)
2,315 citations
Heidelberg University1, Korea Institute for Advanced Study2, University of Nottingham3, Institute of Cosmology and Gravitation, University of Portsmouth4, University of Oxford5, Istituto Nazionale di Fisica Nucleare6, University of Bologna7, INAF8, University of Padua9, University of Toulouse10, University of Geneva11, University of Trieste12, Roma Tre University13, University of Milan14, Federal University of Rio Grande do Norte15, University of Oslo16, University College London17, Imperial College London18, Ludwig Maximilian University of Munich19, Autonomous University of Madrid20, ETH Zurich21, University of Edinburgh22, Leiden University23, Sun Yat-sen University24, Max Planck Society25, Royal Institute of Technology26, University of Milano-Bicocca27, University of California, Berkeley28, University of Pennsylvania29, Universidade Federal do Espírito Santo30, University of Porto31, University of Portsmouth32, King's College London33, Durham University34, Institut d'Astrophysique de Paris35, Helsinki Institute of Physics36, University of Lisbon37, Paris Diderot University38, Université Paris-Saclay39, University of Surrey40, University of Trento41, University of Chile42, Academy of Sciences of the Czech Republic43, University of Cyprus44, University of Barcelona45, California Institute of Technology46, Perimeter Institute for Theoretical Physics47
TL;DR: Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015-2025 program as discussed by the authors, which will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shift of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky.
Abstract: Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015–2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research. In this review we focus on cosmology and fundamental physics, with a strong emphasis on science beyond the current standard models. We discuss five broad topics: dark energy and modified gravity, dark matter, initial conditions, basic assumptions and questions of methodology in the data analysis. This review has been planned and carried out within Euclid’s Theory Working Group and is meant to provide a guide to the scientific themes that will underlie the activity of the group during the preparation of the Euclid mission.
1,211 citations
Federal Urdu University1, Woods Hole Oceanographic Institution2, Columbia University3, Addis Ababa University4, Indian Institute of Tropical Meteorology5, University of Trieste6, Swiss Federal Institute for Forest, Snow and Landscape Research7, University of Bergen8, University of Montpellier9, Austral University of Chile10, University of Chile11, University of Tasmania12, Australian Antarctic Division13, National Oceanic and Atmospheric Administration14, University of Mainz15, Xishuangbanna Tropical Botanical Garden16, Nepal Academy of Science and Technology17, Chinese Academy of Sciences18, University of Melbourne19, Complutense University of Madrid20, Université catholique de Louvain21, University of the Witwatersrand22, Hydrologic Research Center23, University of Bern24, University of Helsinki25, Northern Arizona University26, Fukushima University27, Stockholm University28, Université Paris-Saclay29, National Institute of Water and Atmospheric Research30, University of Giessen31, Swansea University32, Desert Research Institute33, National Scientific and Technical Research Council34, British Antarctic Survey35, Nagoya University36, University of Brighton37, Florida State University38, Alfred Wegener Institute for Polar and Marine Research39, University of New South Wales40, University of Exeter41, Centro de Estudios Científicos42, University of Florence43, University of Texas at Austin44, Russian Academy of Sciences45, University of Washington46, National Centre for Antarctic and Ocean Research47, University of Arizona48, Ghent University49, University of Ottawa50, University of Copenhagen51, University of Colorado Boulder52, Shinshu University53
TL;DR: The authors reconstructed past temperatures for seven continental-scale regions during the past one to two millennia and found that the most coherent feature in nearly all of the regional temperature reconstructions is a long-term cooling trend, which ended late in the nineteenth century.
Abstract: Past global climate changes had strong regional expression To elucidate their spatio-temporal pattern, we reconstructed past temperatures for seven continental-scale regions during the past one to two millennia The most coherent feature in nearly all of the regional temperature reconstructions is a long-term cooling trend, which ended late in the nineteenth century At multi-decadal to centennial scales, temperature variability shows distinctly different regional patterns, with more similarity within each hemisphere than between them There were no globally synchronous multi-decadal warm or cold intervals that define a worldwide Medieval Warm Period or Little Ice Age, but all reconstructions show generally cold conditions between ad 1580 and 1880, punctuated in some regions by warm decades during the eighteenth century The transition to these colder conditions occurred earlier in the Arctic, Europe and Asia than in North America or the Southern Hemisphere regions Recent warming reversed the long-term cooling; during the period ad 1971–2000, the area-weighted average reconstructed temperature was higher than any other time in nearly 1,400 years
885 citations
TL;DR: In this paper, the results of the four LEP experiments were combined to determine fundamental properties of the W boson and the electroweak theory, including the branching fraction of W and the trilinear gauge-boson self-couplings.
684 citations
University of Colorado Denver1, Vanderbilt University2, University of California, San Francisco3, Imperial College London4, University of Texas Southwestern Medical Center5, University of Iceland6, University of Pittsburgh7, National Autonomous University of Mexico8, University of Ulsan9, University of Minnesota10, Council on Education for Public Health11, Université Paris-Saclay12, Quintiles13
TL;DR: The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Abstract: We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 × 10(-8) to 1.1 × 10(-19)), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
649 citations
University of Queensland1, Nuffield Orthopaedic Centre2, Hanyang University3, Cedars-Sinai Medical Center4, National Institutes of Health5, University of Paris6, University of Oslo7, Danube University Krems8, King Abdulaziz University9, National Institute for Health and Welfare10, Second Military Medical University11, Ghent University12, National Autonomous University of Mexico13, University of Otago14, University of Toronto15, Royal Brisbane and Women's Hospital16, Autonomous University of Madrid17, Central University, India18, Wellcome Trust Sanger Institute19, University of Oxford20, Norfolk and Norwich University Hospital21, University of Cambridge22, University Health Network23, Memorial University of Newfoundland24, University of Alberta25, Nova Southeastern University26, Norwegian University of Science and Technology27, Universidad de La Sabana28, Spanish National Research Council29, Université Paris-Saclay30, Medical Research Council31
TL;DR: In this paper, the authors used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls.
Abstract: Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis-associated haplotypes at 11 loci. Two ankylosing spondylitis-associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.
620 citations
TL;DR: The concept for this analysis is to a large degree based on earlier BABAR work and we acknowledge the guidance provided by M. Mazur as discussed by the authors, who consulted with theorists A. Datta, S. Westhoff,S. Fajfer, J. Kamenik, and I. Nisandzic on the calculations of the charged Higgs contributions to the decay rates.
Abstract: The concept for this analysis is to a large degree based on earlier BABAR work and we acknowledge the guidance provided by M. Mazur. The authors consulted with theorists A. Datta, S. Westhoff, S. Fajfer, J. Kamenik, and I. Nisandzic on the calculations of the charged Higgs contributions to the decay rates. We are grateful for the extraordinary contributions of our PEP-II colleagues in achieving the excellent luminosity and machine conditions that have made this work possible. The success of this project also relied critically on the expertise and dedication of the computing organizations that support BABAR. The collaborating institutions wish to thank SLAC for its support and the kind hospitality extended to them. This work is supported by the U.S. Department of Energy and National Science Foundation, the Natural Sciences and Engineering Research Council (Canada), the Commissariat a l'Energie Atomique and Institut National de Physique Nucleaire et de Physique des Particules (France), the Bundesministerium fur Bildung und Forschung and Deutsche Forschungsgemeinschaft (Germany), the Istituto Nazionale di Fisica Nucleare (Italy), the Foundation for Fundamental Research on Matter (Netherlands), the Research Council of Norway, the Ministry of Education and Science of the Russian Federation, Ministerio de Economia y Competitividad (Spain), and the Science and Technology Facilities Council (United Kingdom). Individuals have received support from the Marie-Curie IEF program (European Union) and the A. P. Sloan Foundation (USA).
607 citations
Kyoto University1, Nagoya University2, KEK3, Brookhaven National Laboratory4, Université Paris-Saclay5, University of Washington6, University of Connecticut7, University of Bern8, Spanish National Research Council9, University of Southern Denmark10, University of Rome Tor Vergata11, Forschungszentrum Jülich12, University of Wuppertal13, Osaka University14, San Francisco State University15, Indiana University16, Graduate University for Advanced Studies17, American Physical Society18, University of Edinburgh19, University of Southampton20, Aix-Marseille University21, National Chiao Tung University22, Roma Tre University23, Columbia University24, Autonomous University of Madrid25, University of Mainz26
TL;DR: In this article, a review of lattice results related to pion, kaon, D- and B-meson physics with the aim of making them easily accessible to the particle physics community is presented.
Abstract: We review lattice results related to pion, kaon, D- and B-meson physics with the aim of making them easily accessible to the particle physics community. More specifically, we report on the determination of the light-quark masses, the form factor f+(0), arising in semileptonic K -> pi transition at zero momentum transfer, as well as the decay constant ratio fK/fpi of decay constants and its consequences for the CKM matrix elements Vus and Vud. Furthermore, we describe the results obtained on the lattice for some of the low-energy constants of SU(2)LxSU(2)R and SU(3)LxSU(3)R Chiral Perturbation Theory and review the determination of the BK parameter of neutral kaon mixing. The inclusion of heavy-quark quantities significantly expands the FLAG scope with respect to the previous review. Therefore, for this review, we focus on D- and B-meson decay constants, form factors, and mixing parameters, since these are most relevant for the determination of CKM matrix elements and the global CKM unitarity-triangle fit. In addition we review the status of lattice determinations of the strong coupling constant alpha_s.
494 citations
Montserrat Garcia-Closas, Fergus J. Couch1, Sara Lindström2, Kyriaki Michailidou3 +284 more•Institutions (82)
TL;DR: SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.
Abstract: Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
402 citations
TL;DR: The ESA's Planck satellite was launched 14 May 2009 and has been scanning the microwave and sub-millimetre sky continuously since 12 August 2009 as discussed by the authors, where it has measured gravitational lensing of CMB anisotropies at greater than 25 sigma.
Abstract: The ESA's Planck satellite, dedicated to studying the early Universe and its subsequent evolution, was launched 14 May 2009 and has been scanning the microwave and submillimetre sky continuously since 12 August 2009. This paper gives an overview of the mission and its performance, the processing, analysis, and characteristics of the data, the scientific results, and the science data products and papers in the release. The science products include maps of the CMB and diffuse extragalactic foregrounds, a catalogue of compact Galactic and extragalactic sources, and a list of sources detected through the SZ effect. The likelihood code used to assess cosmological models against the Planck data and a lensing likelihood are described. Scientific results include robust support for the standard six-parameter LCDM model of cosmology and improved measurements of its parameters, including a highly significant deviation from scale invariance of the primordial power spectrum. The Planck values for these parameters and others derived from them are significantly different from those previously determined. Several large-scale anomalies in the temperature distribution of the CMB, first detected by WMAP, are confirmed with higher confidence. Planck sets new limits on the number and mass of neutrinos, and has measured gravitational lensing of CMB anisotropies at greater than 25 sigma. Planck finds no evidence for non-Gaussianity in the CMB. Planck's results agree well with results from the measurements of baryon acoustic oscillations. Planck finds a lower Hubble constant than found in some more local measures. Some tension is also present between the amplitude of matter fluctuations derived from CMB data and that derived from SZ data. The Planck and WMAP power spectra are offset from each other by an average level of about 2% around the first acoustic peak.
367 citations
TL;DR: In this article, the authors measured the kinematics and morphology of [O III]5007 emission and used the observed velocity widths to estimate a median outflow velocity of 760 km/s, similar to or above the escape velocities from the host galaxies.
Abstract: The prevalence and energetics of quasar feedback is a major unresolved problem in galaxy formation theory. In this paper, we present Gemini Integral Field Unit observations of ionized gas around eleven luminous, obscured, radio-quiet quasars at z~0.5 out to ~15 kpc from the quasar; specifically, we measure the kinematics and morphology of [O III]5007 emission. The round morphologies of the nebulae and the large line-of-sight velocity widths (with velocities containing 80% of the emission as high as 1000 km/s combined with relatively small velocity difference across them (from 90 to 520 km/s) point toward wide-angle quasi-spherical outflows. We use the observed velocity widths to estimate a median outflow velocity of 760 km/s, similar to or above the escape velocities from the host galaxies. The line-of-sight velocity dispersion declines slightly toward outer parts of the nebulae (by 3% per kpc on average). The majority of nebulae show blueshifted excesses in their line profiles across most of their extents, signifying gas outflows. For the median outflow velocity, we find a kinetic energy flow between 4x10^{44} and 3x10^{45} erg/s and mass outflow rate between 2000 and 20000 Msun/yr. These values are large enough for the observed quasar winds to have a significant impact on their host galaxies. The median rate of converting bolometric luminosity to kinetic energy of ionized gas clouds is ~2%. We report four new candidates for "super-bubbles" -- outflows that may have broken out of the denser regions of the host galaxy.
Université Paris-Saclay1, International Agency for Research on Cancer2, Harvard University3, State University of New York Upstate Medical University4, French Institute of Health and Medical Research5, Queen's University6, Medical University of Vienna7, Autonomous University of Barcelona8, University of Toronto9
TL;DR: KRAS mutation status is not significantly prognostic and cannot be recommended to select patients with NSCLC for ACT, and the potential interaction in patients with codon-13 mutations requires validation.
Abstract: Purpose We undertook this analysis of KRAS mutation in four trials of adjuvant chemotherapy (ACT) versus observation (OBS) to clarify the prognostic/predictive roles of KRAS in non–small-cell lung cancer (NSCLC). Methods KRAS mutation was determined in blinded fashion. Exploratory analyses were performed to characterize relationships between mutation status and subtype and survival outcomes using a multivariable Cox model. Results Among 1,543 patients (763 OBS, 780 ACT), 300 had KRAS mutations (codon 12, n = 275; codon 13, n = 24; codon 14, n = 1). In OBS patients, there was no prognostic difference for overall survival for codon-12 (mutation v wild type [WT] hazard ratio [HR] = 1.04; 95% CI, 0.77 to 1.40) or codon-13 (HR = 1.01; 95% CI, 0.47 to 2.17) mutations. No significant benefit from ACT was observed for WT-KRAS (ACT v OBS HR = 0.89; 95% CI, 0.76 to 1.04; P = .15) or codon-12 mutations (HR = 0.95; 95% CI, 0.67 to 1.35; P = .77); with codon-13 mutations, ACT was deleterious (HR = 5.78; 95% CI, 2.06 t...
TL;DR: The pre-print version of the final publishing paper that is available from the link below as mentioned in this paper is also available from Amazon Mechanical Turk, however, the preprint version requires a subscription.
Abstract: The article is the pre-print version of the final publishing paper that is available from the link below.
Lawrence Berkeley National Laboratory1, University of Arizona2, University of California, Berkeley3, Drexel University4, Max Planck Society5, University of Wyoming6, Université Paris-Saclay7, Princeton University8, University of Washington9, Harvard University10, Pennsylvania State University11, University of Paris12, New Mexico State University13, Carnegie Mellon University14, University of Florida15, University of Portsmouth16, New York University17, Institut d'Astrophysique de Paris18, University of Chile19, Yale University20, University of Tokyo21, Spanish National Research Council22, Ohio State University23, University of Chicago24
TL;DR: In this paper, a new measurement of the optical quasar luminosity function (QLF) is presented, using data from the Sloan Digital Sky Survey-III: Baryon Oscillation Spectroscopic Survey (SDSS-III): BOSS, with confirmed spectroscopic redshifts between 2.2 and 3.5.
Abstract: We present a new measurement of the optical quasar luminosity function (QLF), using data from the Sloan Digital Sky Survey-III: Baryon Oscillation Spectroscopic Survey (SDSS-III: BOSS). From the SDSS-III Data Release Nine, a uniform sample of 22,301 i {approx}< 21.8 quasars are selected over an area of 2236 deg{sup 2}, with confirmed spectroscopic redshifts between 2.2 < z < 3.5, filling in a key part of the luminosity-redshift plane for optical quasar studies. The completeness of the survey is derived through simulated quasar photometry, and this completeness estimate is checked using a sample of quasars selected by their photometric variability within the BOSS footprint. We investigate the level of systematics associated with our quasar sample using the simulations, in the process generating color-redshift relations and a new quasar K-correction. We probe the faint end of the QLF to M{sub i} (z = 2.2) Almost-Equal-To -24.5 and see a clear break in the QLF at all redshifts up to z = 3.5. A log-linear relation (in log {Phi}* - M*) for a luminosity evolution and density evolution model is found to adequately describe our data within the range 2.2 < z < 3.5; across this interval the break luminosity increases bymore » a factor of {approx}2.6 while {Phi}* declines by a factor of {approx}8. At z {approx}< 2.2 our data are reasonably well fit by a pure luminosity evolution model, and only a weak signature of ''AGN downsizing'' is seen, in line with recent studies of the hard X-ray luminosity function. We compare our measured QLF to a number of theoretical models and find that models making a variety of assumptions about quasar triggering and halo occupation can fit our data over a wide range of redshifts and luminosities.« less
TL;DR: Ridaforolimus delayed tumor progression to a small statistically significant degree in patients with metastatic sarcoma who experienced benefit with prior chemotherapy and provided a foundation on which to further improve control of sarcomas.
Abstract: Purpose Aberrant mammalian target of rapamycin (mTOR) signaling is common in sarcomas and other malignancies. Drug resistance and toxicities often limit benefits of systemic chemotherapy used to treat metastatic sarcomas. This large randomized placebo-controlled phase III trial evaluated the mTOR inhibitor ridaforolimus to assess maintenance of disease control in advanced sarcomas. Patients and Methods Patients with metastatic soft tissue or bone sarcomas who achieved objective response or stable disease with prior chemotherapy were randomly assigned to receive ridaforolimus 40 mg or placebo once per day for 5 days every week. Primary end point was progression-free survival (PFS); secondary end points included overall survival (OS), best target lesion response, safety, and tolerability. Results A total of 711 patients were enrolled, and 702 received blinded study drug. Ridaforolimus treatment led to a modest, although significant, improvement in PFS per independent review compared with placebo (hazard rat...
TL;DR: In this paper, a search for squarks and gluinos in final states containing jets, missing transverse momentum and no high-p(T) electrons or muons is presented.
Abstract: A search for squarks and gluinos in final states containing jets, missing transverse momentum and no high-p(T) electrons or muons is presented. The data represent the complete sample recorded in 2011 by the ATLAS experiment in 7 TeV proton-proton collisions at the Large Hadron Collider, with a total integrated luminosity of 4.7 fb(-1). No excess above the Standard Model background expectation is observed. Gluino masses below 860 GeV and squark masses below 1320 GeV are excluded at the 95% confidence level in simplified models containing only squarks of the first two generations, a gluino octet and a massless neutralino, for squark or gluino masses below 2 TeV, respectively. Squarks and gluinos with equal masses below 1410 GeV are excluded. In minimal supergravity/constrained minimal supersymmetric Standard Model models with tan beta = 10, A(0) = 0 and mu > 0, squarks and gluinos of equal mass are excluded for masses below 1360 GeV. Constraints are also placed on the parameter space of supersymmetric models with compressed spectra. These limits considerably extend the region of supersymmetric parameter space excluded by previous measurements with the ATLAS detector.
University of Chicago1, California Institute of Technology2, European Southern Observatory3, Diego Portales University4, University of Colorado Boulder5, Université Paris-Saclay6, University of Cambridge7, Argonne National Laboratory8, Dalhousie University9, National Institute of Standards and Technology10, McGill University11, University of California, Berkeley12, University of California, Davis13, Lawrence Berkeley National Laboratory14, University of Arizona15, University of Michigan16, Max Planck Society17, Case Western Reserve University18, University of Minnesota19, Space Telescope Science Institute20, School of the Art Institute of Chicago21, Harvard University22, University of Toronto23
TL;DR: A point-source catalog from 771 deg^2 of the South Pole Telescope Sunyaev-Zel'dovich survey at 95, 150, and 220 GHz is presented in this paper.
Abstract: We present a point-source catalog from 771 deg^2 of the South Pole Telescope Sunyaev-Zel'dovich survey at 95, 150, and 220 GHz We detect 1545 sources above 45σ significance in at least one band Based on their relative brightness between survey bands, we classify the sources into two populations, one dominated by synchrotron emission from active galactic nuclei, and one dominated by thermal emission from dust-enshrouded star-forming galaxies We find 1238 synchrotron and 307 dusty sources We cross-match all sources against external catalogs and find 189 unidentified synchrotron sources and 189 unidentified dusty sources The dusty sources without counterparts are good candidates for high-redshift, strongly lensed submillimeter galaxies We derive number counts for each population from 1 Jy down to roughly 11, 4, and 11 mJy at 95, 150, and 220 GHz We compare these counts with galaxy population models and find that none of the models we consider for either population provide a good fit to the measured counts in all three bands The disparities imply that these measurements will be an important input to the next generation of millimeter-wave extragalactic source population models
TL;DR: Unraveling the mechanisms controlling (1)O(2) production and signaling would enable to investigate the interaction and sensitivity to other abiotic and biotic stress signals and thus allow to better understand why some stressors activate an acclimation, while others provoke a programmed cell death response.
Abstract: Significance: In photosynthetic organisms, excited chlorophylls (Chl) can stimulate the formation of singlet oxygen (1O2), a highly toxic molecule that acts in addition to its damaging nature as an important signaling molecule. Thus, due to this dual role of 1O2, its production and detoxification have to be strictly controlled. Recent Advances: Regulation of pigment synthesis is essential to control 1O2 production, and several components of the Chl synthesis and pigment insertion machineries to assemble and disassemble protein/pigment complexes have recently been identified. Once produced, 1O2 activates a signaling cascade from the chloroplast to the nucleus that can involve multiple mechanisms and stimulate a specific gene expression response. Further, 1O2 signaling was shown to interact with signal cascades of other reactive oxygen species, oxidized carotenoids, and lipid hydroperoxide-derived reactive electrophile species. Critical Issues: Despite recent progresses, hardly anything is known ab...
TL;DR: Rhizobium-legume symbiosis provides a rich source of information for understanding host-controlled endosymbiotic life in eukaryotic cells.
Abstract: Symbiosis between Rhizobium bacteria and legumes leads to the formation of the root nodule. The endosymbiotic bacteria reside in polyploid host cells as membrane-surrounded vesicles where they reduce atmospheric nitrogen to support plant growth by supplying ammonia in exchange for carbon sources and energy. The morphology and physiology of endosymbionts, despite their common function, are highly divergent in different hosts. In galegoid plants, the endosymbionts are terminally differentiated, uncultivable polyploid cells, with remarkably elongated and even branched Y-shaped cells. Bacteroid differentiation is controlled by host peptides, many of which have antibacterial activity and require the bacterial function of BacA. Although the precise and combined action of several hundred host peptides and BacA has yet to be discovered, similarities, especially to certain insect-bacterium symbioses involving likewise host peptides for manipulation of endosymbionts, suggest convergent evolution. Rhizobium-legume s...
TL;DR: A functionally relevant S1/S2 mutation that arises when FIP develops in a cat is documented, which may be useful in development of diagnostic, prevention, and treatment measures against coronaviruses.
Abstract: Feline coronaviruses (FCoV) exist as 2 biotypes: feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV). FECV causes subclinical infections; FIPV causes feline infectious peritonitis (FIP), a systemic and fatal disease. It is thought that mutations in FECV enable infection of macrophages, causing FIP. However, the molecular basis for this biotype switch is unknown. We examined a furin cleavage site in the region between receptor-binding (S1) and fusion (S2) domains of the spike of serotype 1 FCoV. FECV sequences were compared with FIPV sequences. All FECVs had a conserved furin cleavage motif. For FIPV, there was a correlation with the disease and >1 substitution in the S1/S2 motif. Fluorogenic peptide assays confirmed that the substitutions modulate furin cleavage. We document a functionally relevant S1/S2 mutation that arises when FIP develops in a cat. These insights into FIP pathogenesis may be useful in development of diagnostic, prevention, and treatment measures against coronaviruses.
TL;DR: In this paper, the transverse momentum (p(T)) spectra and ratios of identified charged hadrons (pi(+/-), K-+/-, p, (p) over bar) produced in root s(NN) = 200 GeV Au + Au and d + Au collisions are reported in five different centrality classes for each collision species.
Abstract: The transverse momentum (p(T)) spectra and ratios of identified charged hadrons (pi(+/-), K-+/-, p, (p) over bar) produced in root s(NN) = 200 GeV Au + Au and d + Au collisions are reported in five different centrality classes for each collision species. The measurements of pions and protons are reported up to p(T) = 6 GeV/c (5 GeV/c), and the measurements of kaons are reported up to p(T) = 4 GeV/c (3.5 GeV/c) in Au + Au (d + Au) collisions. In the intermediate p(T) region, between 2 and 5 GeV/c, a significant enhancement of baryon-to-meson ratios compared to those measured in p + p collisions is observed. This enhancement is present in both Au + Au and d + Au collisions and increases as the collisions become more central. We compare a class of peripheral Au + Au collisions with a class of central d + Au collisions which have a comparable number of participating nucleons and binary nucleon-nucleon collisions. The p(T)-dependent particle ratios for these classes display a remarkable similarity, which is then discussed.
Broad Institute1, University of Lausanne2, École Polytechnique Fédérale de Lausanne3, Conservatoire national des arts et métiers4, Harvard University5, Utrecht University6, Massachusetts Institute of Technology7, Science Applications International Corporation8, University of Modena and Reggio Emilia9, Autonomous University of Barcelona10, University of California, San Francisco11, University of Oxford12, Catholic University of the Sacred Heart13, National Institutes of Health14, Vanderbilt University15, University of Washington16, Johns Hopkins University17, Université Paris-Saclay18, French Institute of Health and Medical Research19, University of Manitoba20, Public Health Agency of Canada21, Murdoch University22, Sanquin23, Crucell24, University of Barcelona25, University of Copenhagen26, Saint Petersburg State University27, Vita-Salute San Raffaele University28, University of Cambridge29, Wellcome Trust Sanger Institute30, Duke University31, Georgia Institute of Technology32, Howard Hughes Medical Institute33, Uniformed Services University of the Health Sciences34, Northwestern University35
TL;DR: Analysis of genome-wide single nucleotide polymorphism data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size.
Abstract: Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have been interrogated using GWAS, although in generally small samples. Under the auspices of the International Collaboration for the Genomics of HIV, we have combined the genome-wide single nucleotide polymorphism (SNP) data collected by 25 cohorts, studies, or institutions on HIV-1 infected individuals and compared them to carefully matched population-level data sets (a list of all collaborators appears in Note S1 in Text S1). After imputation using the 1,000 Genomes Project reference panel, we tested approximately 8 million common DNA variants (SNPs and indels) for association with HIV-1 acquisition in 6,334 infected patients and 7,247 population samples of European ancestry. Initial association testing identified the SNP rs4418214, the C allele of which is known to tag the HLA-B*57:01 and B*27:05 alleles, as genome-wide significant (p = 3.6×10−11). However, restricting analysis to individuals with a known date of seroconversion suggested that this association was due to the frailty bias in studies of lethal diseases. Further analyses including testing recessive genetic models, testing for bulk effects of non-genome-wide significant variants, stratifying by sexual or parenteral transmission risk and testing previously reported associations showed no evidence for genetic influence on HIV-1 acquisition (with the exception of CCR5Δ32 homozygosity). Thus, these data suggest that genetic influences on HIV acquisition are either rare or have smaller effects than can be detected by this sample size.
TL;DR: The PHENIX experiment has measured the production of pi(0)s in Au + Au collisions at root S-NN = 200 GeV as discussed by the authors, which offers a fourfold increase in recorded luminosity, providing higher precision and a larger reach in transverse momentum, p(T), to 20 GeV/c.
Abstract: The PHENIX experiment has measured the production of pi(0)s in Au + Au collisions at root S-NN = 200 GeV. The new data offer a fourfold increase in recorded luminosity, providing higher precision and a larger reach in transverse momentum, p(T), to 20 GeV/c. The production ratio of eta/pi(0) is 0.46 +/- 0.01(stat) +/- 0.05(syst), constant with p(T) and collision centrality. The observed ratio is consistent with earlier measurements, as well as with the p + p and d + Au values. pi(0) are suppressed by a factor of 5, as in earlier findings. However, with the improved statistical precision a small but significant rise of the nuclear modification factor R-AA vs p(T), with a slope of 0.0106 +/-(0.0034)(0.0029) (Gev/c)(-1), is discernible in central collisions. A phenomenological extraction of the average fractional parton energy loss shows a decrease with increasing p(T). To study the path-length dependence of suppression, the pi(0) yield is measured at different angles with respect to the event plane; a strong azimuthal dependence of the pi(0) R-AA is observed. The data are compared to theoretical models of parton energy loss as a function of the path length L in the medium. Models based on perturbative quantum chromodynamics are insufficient to describe the data, while a hybrid model utilizing pQCD for the hard interactions and anti-de-Sitter space/conformal field theory (AdS/CFT) for the soft interactions is consistent with the data. DOI: 10.1103/PhysRevC.87.034911
TL;DR: In this paper, a search for the decay B+→τ+ν using 467.8×10^6 BB pairs collected at the 4S resonance with the BABAR detector at the SLAC PEP-II B-Factory is presented.
Abstract: We present a search for the decay B+→τ+ν using 467.8×10^6 BB pairs collected at the Υ(4S) resonance with the BABAR detector at the SLAC PEP-II B-Factory. We select a sample of events with one completely reconstructed B- in the hadronic decay mode (B-→D(*)0X- and B-→J/ψX-). We examine the rest of the event to search for a B+→τ+ν decay. We identify the τ+ lepton in the following modes: τ+→e+νν , τ+→μ+νν , τ+→π+ν and τ+→ρ+ν . We find an excess of events with respect to the expected background, which excludes the null signal hypothesis at the level of 3.8σ (including systematic uncertainties) and corresponds to a branching fraction value of B(B+→τ+ν)=(1.83_(-0.49)^(+0.53)(stat)±0.24(syst))×10^(-4).
TL;DR: In this paper, the authors studied the performance of a family of randomized coordinate descent methods for minimizing the sum of nonsmooth and separable convex functions and showed that these methods can find an approximate solution with high probability.
Abstract: We study the performance of a family of randomized parallel coordinate descent methods for minimizing the sum of a nonsmooth and separable convex functions. The problem class includes as a special case L1-regularized L1 regression and the minimization of the exponential loss ("AdaBoost problem"). We assume the input data defining the loss function is contained in a sparse $m\times n$ matrix $A$ with at most $\omega$ nonzeros in each row. Our methods need $O(n \beta/\tau)$ iterations to find an approximate solution with high probability, where $\tau$ is the number of processors and $\beta = 1 + (\omega-1)(\tau-1)/(n-1)$ for the fastest variant. The notation hides dependence on quantities such as the required accuracy and confidence levels and the distance of the starting iterate from an optimal point. Since $\beta/\tau$ is a decreasing function of $\tau$, the method needs fewer iterations when more processors are used. Certain variants of our algorithms perform on average only $O(
nz(A)/n)$ arithmetic operations during a single iteration per processor and, because $\beta$ decreases when $\omega$ does, fewer iterations are needed for sparser problems.
TL;DR: It is found that the modification of the ψ' yield relative to that of the J/ψ scales approximately with charged particle multiplicity at midrapidity across p+A, d+Au, and A+A results from the Super Proton Synchrotron and the Relativistic Heavy Ion Collider.
Abstract: We present results for three charmonia states (psi' chi(c), and J/ psi) in d + Au collisions at vertical bar y vertical bar < 0.35 and root s(NN) = 200 GeV. We find that the modification of the psi' yield relative to that of the J/ psi scales approximately with charged particle multiplicity at midrapidity across p + A, d + Au, and A + A results from the Super Proton Synchrotron and the Relativistic Heavy Ion Collider. In large-impact-parameter collisions we observe a similar suppression for the psi' and J/ psi, while in small-impact-parameter collisions the more weakly bound psi' is more strongly suppressed. Owing to the short time spent traversing the Au nucleus, the larger psi' suppression in central events is not explained by an increase of the nuclear absorption owing to meson formation time effects.
University of Washington1, Weizmann Institute of Science2, Cancer Research UK3, Utrecht University4, Virginia Commonwealth University5, Université libre de Bruxelles6, Barcelona Supercomputing Center7, Uppsala University8, Johns Hopkins University9, University of Grenoble10, French Institute for Research in Computer Science and Automation11, Purdue University12, University of Missouri13, University of Wisconsin-Madison14, Ochanomizu University15, Osaka University16, Seoul National University17, Kitasato University18, Chuo University19, Boston University20, University of Massachusetts Medical School21, Huazhong University of Science and Technology22, Technische Universität München23, Florida State University24, Université Paris-Saclay25, University of Toronto26
TL;DR: A community‐wide assessment of methods to predict the effects of mutations on protein–protein interactions found that large‐scale fitness landscapes should continue to provide an excellent test bed for continued evaluation of both existing and new prediction methodologies.
Abstract: Community-wide blind prediction experiments such as CAPRI and CASP provide an objective measure of the current state of predictive methodology. Here we describe a community-wide assessment of methods to predict the effects of mutations on protein-protein interactions. Twenty-two groups predicted the effects of comprehensive saturation mutagenesis for two designed influenza hemagglutinin binders and the results were compared with experimental yeast display enrichment data obtained using deep sequencing. The most successful methods explicitly considered the effects of mutation on monomer stability in addition to binding affinity, carried out explicit side-chain sampling and backbone relaxation, evaluated packing, electrostatic, and solvation effects, and correctly identified around a third of the beneficial mutations. Much room for improvement remains for even the best techniques, and large-scale fitness landscapes should continue to provide an excellent test bed for continued evaluation of both existing and new prediction methodologies.
TL;DR: In this paper, the authors describe the resulting phenomenology of string theory/supergravity models with strong moduli stabilization, and compute the low-energy spectrum as a function of m 3/2.
Abstract: We describe the resulting phenomenology of string theory/supergravity models with strong moduli stabilization. The KL model with F-term uplifting, is one such example. Models of this type predict universal scalar masses equal to the gravitino mass. In contrast, A-terms receive highly suppressed gravity mediated contributions. Under certain conditions, the same conclusion is valid for gaugino masses, which like A-terms, are then determined by anomalies. In such models, we are forced to relatively large gravitino masses (30–1000 TeV). We compute the low-energy spectrum as a function of m
3/2. We see that the Higgs masses naturally takes values between 125–130 GeV. The lower limit is obtained from the requirement of chargino masses greater than 104 GeV, while the upper limit is determined by the relic density of dark matter (wino-like).
Georges Aad1, Alexander Kupco2, Bjørn Hallvard Samset3, Paolo Laurelli +2926 more•Institutions (187)
TL;DR: In this paper, a summary of beam-induced background observed in the ATLAS detector and methods to tag and remove background contaminated events in data are discussed, and the correlations of background with machine conditions, such as residual pressure in the beam-pipe, are discussed.
Abstract: This paper presents a summary of beam-induced backgrounds observed in the ATLAS detector and discusses methods to tag and remove background contaminated events in data. Trigger-rate based monitoring of beam-related backgrounds is presented. The correlations of backgrounds with machine conditions, such as residual pressure in the beam-pipe, are discussed. Results from dedicated beam-background simulations are shown, and their qualitative agreement with data is evaluated. Data taken during the passage of unpaired, i.e. non-colliding, proton bunches is used to obtain background-enriched data samples. These are used to identify characteristic features of beam-induced backgrounds, which then are exploited to develop dedicated background tagging tools. These tools, based on observables in the Pixel detector, the muon spectrometer and the calorimeters, are described in detail and their efficiencies are evaluated. Finally an example of an application of these techniques to a monojet analysis is given, which demonstrates the importance of such event cleaning techniques for some new physics searches.
TL;DR: It is demonstrated that PRL inhibits the apoptosis of cultured chondrocytes in response to a mixture of proinflammatory cytokines by preventing the induction of p53 and decreasing the BAX/BCL-2 ratio through a NO-independent, JAK2/STAT3-dependent pathway.
Abstract: Chondrocytes are the only cells in cartilage, and their death by apoptosis contributes to cartilage loss in inflammatory joint diseases, such as rheumatoid arthritis (RA). A putative therapeutic intervention for RA is the inhibition of apoptosis-mediated cartilage degradation. The hormone prolactin (PRL) frequently increases in the circulation of patients with RA, but the role of hyperprolactinemia in disease activity is unclear. Here, we demonstrate that PRL inhibits the apoptosis of cultured chondrocytes in response to a mixture of proinflammatory cytokines (TNF-α, IL-1β, and IFN-γ) by preventing the induction of p53 and decreasing the BAX/BCL-2 ratio through a NO-independent, JAK2/STAT3-dependent pathway. Local treatment with PRL or increasing PRL circulating levels also prevented chondrocyte apoptosis evoked by injecting cytokines into the knee joints of rats, whereas the proapoptotic effect of cytokines was enhanced in PRL receptor-null (Prlr(-/-)) mice. Moreover, eliciting hyperprolactinemia in rats before or after inducing the adjuvant model of inflammatory arthritis reduced chondrocyte apoptosis, proinflammatory cytokine expression, pannus formation, bone erosion, joint swelling, and pain. These results reveal the protective effect of PRL against inflammation-induced chondrocyte apoptosis and the therapeutic potential of hyperprolactinemia to reduce permanent joint damage and inflammation in RA.