University at Buffalo

About: University at Buffalo is a education organization based out in Buffalo, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 33773 authors who have published 63840 publications receiving 2278954 citations. The organization is also known as: UB & State University of New York at Buffalo.

Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study.

Abstract: Background—Weight gain is of concern during early development because adult obesity and its cardiovascular consequences appear to have their origins during childhood. Insulin resistance is known to be related to obesity. Thus, weight gain beginning in childhood may influence the development of insulin-induced cardiovascular risk during adulthood. Methods and Results—We monitored 679 individuals from 7.7±0.1 years of age with repeated measures of height, weight, and systolic blood pressure (SBP) until 23.6±0.2 years of age, when blood samples were obtained for measurements of insulin and lipids. Initial childhood weight, body mass index (BMI), and height were significantly correlated with young adult weight, BMI, and height and with fasting insulin, lipids, and SBP. The increases in weight and BMI but not height during childhood were significantly related to the young adult levels of insulin, lipids, and SBP. Conclusions—These data suggest that weight gain in excess of normal growth during childhood is a d...

Search for dark matter, extra dimensions, and unparticles in monojet events in proton–proton collisions at √s = 8 TeV

Abstract: Results are presented from a search for particle dark matter (DM), extra dimensions, and unparticles using events containing a jet and an imbalance in transverse momentum. The data were collected by the CMS detector in proton-proton collisions at the LHC and correspond to an integrated luminosity of 19.7 fb$^{-1}$ at a centre-of-mass energy of 8 TeV. The number of observed events is found to be consistent with the standard model prediction. Limits are placed on the DM-nucleon scattering cross section as a function of the DM particle mass for spin-dependent and spin-independent interactions. Limits are also placed on the scale parameter $M_\mathrm{D}$ in the ADD model of large extra dimensions, and on the unparticle model parameter $\Lambda_\mathrm{U}$. The constraints on ADD models and unparticles are the most stringent limits in this channel and those on the DM-nucleon scattering cross section are an improvement over previous collider results.

Resolving conflicts in heterogeneous data by truth discovery and source reliability estimation

Abstract: In many applications, one can obtain descriptions about the same objects or events from a variety of sources. As a result, this will inevitably lead to data or information conflicts. One important problem is to identify the true information (i.e., the truths) among conflicting sources of data. It is intuitive to trust reliable sources more when deriving the truths, but it is usually unknown which one is more reliable a priori. Moreover, each source possesses a variety of properties with different data types. An accurate estimation of source reliability has to be made by modeling multiple properties in a unified model. Existing conflict resolution work either does not conduct source reliability estimation, or models multiple properties separately. In this paper, we propose to resolve conflicts among multiple sources of heterogeneous data types. We model the problem using an optimization framework where truths and source reliability are defined as two sets of unknown variables. The objective is to minimize the overall weighted deviation between the truths and the multi-source observations where each source is weighted by its reliability. Different loss functions can be incorporated into this framework to recognize the characteristics of various data types, and efficient computation approaches are developed. Experiments on real-world weather, stock and flight data as well as simulated multi-source data demonstrate the necessity of jointly modeling different data types in the proposed framework.

ADAPT FAST study: a direct aspiration first pass technique for acute stroke thrombectomy

Abstract: Background The development of new revascularization devices has improved recanalization rates and time, but not clinical outcomes. We report a prospectively collected clinical experience with a new technique utilizing a direct aspiration first pass technique with large bore aspiration catheter as the primary method for vessel recanalization. Methods 98 prospectively identified acute ischemic stroke patients with 100 occluded large cerebral vessels at six institutions were included in the study. The ADAPT technique was utilized in all patients. Procedural and clinical data were captured for analysis. Results The aspiration component of the ADAPT technique alone was successful in achieving Thrombolysis in Cerebral Infarction (TICI) 2b or 3 revascularization in 78% of cases. The additional use of stent retrievers improved the TICI 2b/3 revascularization rate to 95%. The average time from groin puncture to at least TICI 2b recanalization was 37 min. A 5MAX demonstrated similar success to a 5MAX ACE in achieving TICI 2b/3 revascularization alone (75% vs 82%, p=0.43). Patients presented with an admitting median National Institutes of Health Stroke Scale (NIHSS) score of 17.0 (12.0–21.0) and improved to a median NIHSS score at discharge of 7.3 (1.0–11.0). Ninety day functional outcomes were 40% (modified Rankin Scale (mRS) 0–2) and 20% (mRS 6). There were two procedural complications and no symptomatic intracerebral hemorrhages. Discussion The ADAPT technique is a fast, safe, simple, and effective method that has facilitated our approach to acute ischemic stroke thrombectomy by utilizing the latest generation of large bore aspiration catheters to achieve previously unparalleled angiographic outcomes.