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Institution

University at Buffalo

EducationBuffalo, New York, United States
About: University at Buffalo is a education organization based out in Buffalo, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 33773 authors who have published 63840 publications receiving 2278954 citations. The organization is also known as: UB & State University of New York at Buffalo.


Papers
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Journal ArticleDOI
TL;DR: In COURAGE patients who underwent serial MPS, adding PCI to OMT resulted in greater reduction in ischemia compared with OMT alone, and the findings suggest a treatment target of ≥5% ischemic myocardium reduction with O MT with or without coronary revascularization.
Abstract: Background— Extent and severity of myocardial ischemia are determinants of risk for patients with coronary artery disease, and ischemia reduction is an important therapeutic goal. The Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation (COURAGE) nuclear substudy compared the effectiveness of percutaneous coronary intervention (PCI) for ischemia reduction added to optimal medical therapy (OMT) with the use of myocardial perfusion single photon emission computed tomography (MPS). Methods and Results— Of the 2287 COURAGE patients, 314 were enrolled in this substudy of serial rest/stress MPS performed before treatment and 6 to 18 months (mean=374±50 days) after randomization using paired exercise (n=84) or vasodilator stress (n=230). A blinded core laboratory analyzed quantitative MPS measures of percent ischemic myocardium. Moderate to severe ischemia encumbered ≥10% myocardium. The primary end point was ≥5% reduction in ischemic myocardium at follow-up. Treatment groups had similar ...

1,514 citations

Journal ArticleDOI
TL;DR: The most striking feature of the USA300 genome is the horizontal acquisition of a novel mobile genetic element that encodes an arginine deiminase pathway and an oligopeptide permease system that could contribute to growth and survival of USA300.

1,507 citations

Journal ArticleDOI
TL;DR: In this article, the authors trace the history of diffusion for 46 new products and examine the interrelations among diffusion, other aspects of technological change, price, output, and certain attributes of the relevant markets.
Abstract: This study attempts to measure and analyse the diffusion of product innovations. Diffusion is defined as the spread in the number of producers engaged in manufacturing a new product. Thus, the term refers to the net entry rate in the market for a new product. We trace the history of diffusion for 46 new products and examine the inter-relations among diffusion, other aspects of technological change, price, output, and certain attributes of the relevant markets. To explain the 46 product histories, we construct a theory of the development of industries for new products. Our theory combines elements of traditional, neoclassical models with what Nelson and Winter (I974) have termed an evolutionary theory. A novel feature is that the historical sequence, or time path, of events is viewed as a critical determinant of the ultimate structure of new product markets. Thus the time path of events determines not only the course traversed in reaching the end result but the ultimate market structure itself. The paper is organised in four sections. In Section I we present our theory. In Section II we construct a series of alternative theories of the development of industries for new products based on approaches to be found in received literature. The evidence from the 46 new product histories is examined in Section III. Finally, a brief summary of principal findings follows in Section IV.

1,487 citations

Journal ArticleDOI
TL;DR: Recent studies concerning cholesterol, its behavior and its roles in cell growth provide important new clues to the role of this fascinating molecule in normal and pathological states.

1,457 citations

Journal ArticleDOI
01 Aug 1956
TL;DR: In this article, the gross bulk and shear moduli of a composite material consisting of a suspension of grains or a compact of grains are derived from an analysis of the dilatation and bulk stress for average spherical grains when the composite as a whole is subjected to some small temperature change.
Abstract: In a continuation of a previous paper, it is shown here how the gross bulk and shear moduli of a composite material consisting of a suspension of grains or a compact of grains may be deduced. The grains are assumed to be perfectly bonded to the suspending medium or to each other, and are taken to be spheres in the mean. By using an averaging procedure due to Bruggeman, and analysing the effect of a uniform hydrostatic compression and of a uniform tension on an average grain, a pair of de-coupled equations for the gross moduli is found for suspensions. When the suspending medium vanishes and the grains are packed, these equations become coupled and there is exhibited a discontinuity in the gross moduli. The bulk coefficients of linear expansion of the two kinds of composites are found from an analysis of the dilatation and bulk stress for average spherical grains when the composite as a whole is subjected to some small temperature change. All results are free of any limitation on the number of components.

1,454 citations


Authors

Showing all 34002 results

NameH-indexPapersCitations
Rakesh K. Jain2001467177727
Julie E. Buring186950132967
Anil K. Jain1831016192151
Donald G. Truhlar1651518157965
Roger A. Nicoll16539784121
Bruce L. Miller1631153115975
David R. Holmes1611624114187
Suvadeep Bose154960129071
Ashok Kumar1515654164086
Philip S. Yu1481914107374
Hugh A. Sampson14781676492
Aaron Dominguez1471968113224
Gregory R Snow1471704115677
J. S. Keller14498198249
C. Ronald Kahn14452579809
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202388
2022363
20212,772
20202,695
20192,527
20182,500