Institution
University at Buffalo
Education•Buffalo, New York, United States•
About: University at Buffalo is a education organization based out in Buffalo, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 33773 authors who have published 63840 publications receiving 2278954 citations. The organization is also known as: UB & State University of New York at Buffalo.
Papers published on a yearly basis
Papers
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TL;DR: The first substantial improvement of the 20-year-old classical harmonic upper bound,H(m), of Johnson, Lovasz, and Chvatal, is provided and the approximation guarantee for the greedy algorithm is better than the guarantee recently established by Srinivasan for the randomized rounding technique, thus improving the bounds on theintegrality gap.
299 citations
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TL;DR: By labeling replicated DNA at the G1/S borders for two consecutive cell generations, it is shown that the DNA synthesized at early S-phase is replicated at the same time and sites in the next round of replication.
Abstract: Fluorescence microscopic analysis of newly replicated DNA has revealed discrete granular sites of replication (RS). The average size and number of replication sites from early to mid S-phase suggest that each RS contains numerous replicons clustered together. We are using fluorescence laser scanning confocal microscopy in conjunction with multidimensional image analysis to gain more precise information about RS and their spatial-temporal dynamics. Using a newly improved imaging segmentation program, we report an average of ∼1,100 RS after a 5-min pulse labeling of 3T3 mouse fibroblast cells in early S-phase. Pulse-chase-pulse double labeling experiments reveal that RS take ∼45 min to complete replication. Appropriate calculations suggest that each RS contains an average of 1 mbp of DNA or ∼6 average-sized replicons. Double pulse–double chase experiments demonstrate that the DNA sequences replicated at individual RS are precisely maintained temporally and spatially as the cell progresses through the cell cycle and into subsequent generations. By labeling replicated DNA at the G1/S borders for two consecutive cell generations, we show that the DNA synthesized at early S-phase is replicated at the same time and sites in the next round of replication.
299 citations
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TL;DR: In this paper, the problem of surface detection is translated into a problem of traversal of a directed graph, G, and it is proven that connected subgraphs of G correspond to surfaces of connected components of Q (i.e., of objects in the scene).
299 citations
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TL;DR: The current review provides an update on melatonin receptors by the corresponding subcommittee of the International Union of Basic and Clinical Pharmacology, and highlights recent developments of melatonin receptor ligands, including radioligands, and gives anupdate on the latest phenotyping results ofmelatonin receptor knockout mice.
Abstract: Melatonin receptors are seven transmembrane-spanning proteins belonging to the G protein-coupled receptor super-family. In mammals, two melatonin receptor subtypes exit MT1 and MT2 encoded by the MTNR1A and MTNR1B genes, respectively. The current review provides an update on melatonin receptors by the corresponding sub-committee of the International Union of Basic and Clinical Pharmacology. We will highlight recent developments of melatonin receptor ligands, including radioligands and give an update on the latest phenotyping results of melatonin receptor knockout mice. The current status and perspectives of the structure of melatonin receptor structures will be summarized. The physiological importance of melatonin receptor dimers and biologically important and type 2 diabetes-associated genetic variants of melatonin receptors will be discussed. The role of melatonin receptors in physiology and disease will be further exemplified by its functions in the immune system and the central nervous system. Finally, antioxidant and free radical scavenger properties of melatonin and its relation to melatonin receptors will be critically addressed.
299 citations
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14 Mar 2004TL;DR: In this paper, the authors propose a method to preserve data consistency in the case of integration of several data sources, even if the sources are separately consistent, the integrated data can violate the integrity constraints.
Abstract: Integrity constraints express important properties of data, but the task of preserving data consistency is becoming increasingly problematic with new database applications. For example, in the case of integration of several data sources, even if the sources are separately consistent, the integrated data can violate the integrity constraints. The traditional approach, removing the conflicting data, is not a good option because the sources can be autonomous. Another scenario is a long-running activity where consistency can be violated only temporarily and future updates will restore it. Finally, data consistency may be neglected because of efficiency or other reasons.
299 citations
Authors
Showing all 34002 results
Name | H-index | Papers | Citations |
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Rakesh K. Jain | 200 | 1467 | 177727 |
Julie E. Buring | 186 | 950 | 132967 |
Anil K. Jain | 183 | 1016 | 192151 |
Donald G. Truhlar | 165 | 1518 | 157965 |
Roger A. Nicoll | 165 | 397 | 84121 |
Bruce L. Miller | 163 | 1153 | 115975 |
David R. Holmes | 161 | 1624 | 114187 |
Suvadeep Bose | 154 | 960 | 129071 |
Ashok Kumar | 151 | 5654 | 164086 |
Philip S. Yu | 148 | 1914 | 107374 |
Hugh A. Sampson | 147 | 816 | 76492 |
Aaron Dominguez | 147 | 1968 | 113224 |
Gregory R Snow | 147 | 1704 | 115677 |
J. S. Keller | 144 | 981 | 98249 |
C. Ronald Kahn | 144 | 525 | 79809 |