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Institution

University at Buffalo

EducationBuffalo, New York, United States
About: University at Buffalo is a education organization based out in Buffalo, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 33773 authors who have published 63840 publications receiving 2278954 citations. The organization is also known as: UB & State University of New York at Buffalo.


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Journal ArticleDOI
TL;DR: The proposition that well-developed SLAs not only provide a way to measure the service provider's performance, but also enable effective management of outsourcing engagements through the development of partnership-style relationships with high levels of trust and commitment is supported.
Abstract: This study extends the view that formal contracts and relational governance function as complements rather than as substitutes. We investigate how specific characteristics of service level agreements (SLAs) impact relational governance in information technology outsourcing relationships. Eleven contractual elements (categorized into three SLA characteristics: foundation, change, and governance characteristics) are hypothesized to act as complements of three relational governance attributes: relational norms, harmonious conflict resolution, and mutual dependence. Data for the study were collected through a survey of South Korean IT executives. Results of the study support the fundamental proposition of complementarity between formal contracts and relational governance, and indicate that well-structured SLAs have significant positive influence on the various aspects of relational governance in IT outsourcing relationships. However, the study also reveals that change characteristics of SLAs may act as a substitute for relational governance as these characteristics were found to dampen the level of trust and commitment through moderation effects. Overall, the findings support the proposition that well-developed SLAs not only provide a way to measure the service provider's performance, but also enable effective management of outsourcing engagements through the development of partnership-style relationships with high levels of trust and commitment.

501 citations

Journal ArticleDOI
TL;DR: Recurrent prostate cancer may develop the capacity to biosynthesize testicular androgens from adrenal androgens or cholesterol, a surprising finding that suggests intracrine production of dihydrotestosterone should be exploited for novel treatment of recurrent prostate cancer.
Abstract: Purpose: Prostate cancer eventually recurs during androgen deprivation therapy despite castrate levels of serum androgens. Expression of androgen receptor and androgen receptor–regulated proteins suggests androgen receptor activation in recurrent prostate cancer. Many groups have pursued mechanisms of ligand-independent androgen receptor activation but we found high levels of testicular androgens in recurrent prostate cancer tissue using RIA. Experimental Designs: Prostate specimens from 36 men were procured preserving blood flow to prevent ischemia and cyropreserved immediately. Recurrent prostate cancer specimens from 18 men whose cancer recurred locally during androgen deprivation therapy and androgen-stimulated benign prostate specimens from 18 men receiving no hormonal treatments were studied. Tissue levels of testosterone and dihydrotestosterone were measured in each specimen using liquid chromatography/electrospray tandem mass spectrometry. Testosterone and dihydrotestosterone levels were compared with clinical variables and treatment received. Results: Testosterone levels were similar in recurrent prostate cancer (3.75 pmol/g tissue) and androgen-stimulated benign prostate (2.75 pmol/g tissue, Wilcoxon two-sided, P = 0.30). Dihydrotestosterone levels decreased 91% in recurrent prostate cancer (1.25 pmol/g tissue) compared with androgen-stimulated benign prostate (13.7 pmol/g tissue; Wilcoxon two-sided, P P > 0.2). Conclusions: Recurrent prostate cancer may develop the capacity to biosynthesize testicular androgens from adrenal androgens or cholesterol. This surprising finding suggests intracrine production of dihydrotestosterone and should be exploited for novel treatment of recurrent prostate cancer.

499 citations

Journal ArticleDOI
TL;DR: Mucins are the principal organic constituents of mucus, the slimy visco-elastic material that coats all mucosal surfaces, and compelling evidence suggests that they play an integral role in non-immune protection of the oral cavity.
Abstract: Mucins are the principal organic constituents of mucus, the slimy visco-elastic material that coats all mucosal surfaces. Compelling evidence suggests that they play an integral role in non-immune protection of the oral cavity. Specific protective functions include: 1) protection against desiccation and environmental insult, 2) lubrication, and 3) antimicrobial effects against potential pathogens. Biosynthesis of mucin is regulated by both intrinsic ("cooperative sequential specificity") and extrinsic ("structural modulation") controls. These controls form the basis by which mucin's structure can be modified to meet a dynamically changing biological need.

499 citations

Journal ArticleDOI
TL;DR: According to cognitive dissonance theory, people are motivated to preserve the belief that existing social arrangements are fair, legitimate, justifiable, and necessary as discussed by the authors, and they are paradoxically the least likely to question, challenge, reject, or change it.
Abstract: According to system justification theory, people are motivated to preserve the belief that existing social arrangements are fair, legitimate, justifiable, and necessary. The strongest form of this hypothesis, which draws on the logic of cognitive dissonance theory, holds that people who are most disadvantaged by the status quo would have the greatest psychological need to reduce ideological dissonance and would therefore be most likely to support, defend, and justify existing social systems, authorities, and outcomes. Variations on this hypothesis were tested in five US national survey studies. We found that (a) low-income respondents and African Americans were more likely than others to support limitations on the rights of citizens and media representatives to criticize the government; (b) low-income Latinos were more likely to trust in US government officials and to believe that ‘the government is run for the benefit of all’ than were high-income Latinos; (c) low-income respondents were more likely than high-income respondents to believe that large differences in pay are necessary to foster motivation and effort; (d) Southerners in the USA were more likely to endorse meritocratic belief systems than were Northerners and poor and Southern African Americans were more likely to subscribe to meritocratic ideologies than were African Americans who were more affluent and from the North; (e) low-income respondents and African Americans were more likely than others to believe that economic inequality is legitimate and necessary; and (f) stronger endorsement of meritocratic ideology was associated with greater satisfaction with one's own economic situation. Taken together, these findings are consistent with the dissonance-based argument that people who suffer the most from a given state of affairs are paradoxically the least likely to question, challenge, reject, or change it. Implications for theories of system justification, cognitive dissonance, and social change are also discussed. Copyright © 2002 John Wiley & Sons, Ltd.

499 citations

Journal ArticleDOI
14 Apr 1998-Langmuir
TL;DR: In this article, a ternary isothermal system consisting of a poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) amphiphilic block copolymer, "water" and "oil" are selected solvents for the different blocks.
Abstract: We report on a ternary isothermal system consisting of a poly(ethylene oxide)/poly(propylene oxide) (PEO/PPO) amphiphilic block copolymer, “water”, and “oil” (where “water” and “oil” are selective solvents for the different blocks), which exhibits the richest structural polymorphism ever observed (in equilibrium) in mixtures containing amphiphiles (such as block copolymers, surfactants, or lipids). The microstructure resulting from the self-assembly of the PEO/PPO block copolymer can vary from normal (oil-in-water) micelles in solution, through all types of normal and reverse (water-in-oil) lyotropic liquid crystals (normal micellar cubic, normal hexagonal, normal bicontinuous cubic, lamellar, reverse bicontinuous cubic, reverse hexagonal, reverse micellar cubic), to reverse micelles, as the relative volume fraction of the apolar (“oil”-like) components increases over that of the polar (“water”-like) components. The structure in the liquid crystalline phases has been established with small-angle X-ray sca...

499 citations


Authors

Showing all 34002 results

NameH-indexPapersCitations
Rakesh K. Jain2001467177727
Julie E. Buring186950132967
Anil K. Jain1831016192151
Donald G. Truhlar1651518157965
Roger A. Nicoll16539784121
Bruce L. Miller1631153115975
David R. Holmes1611624114187
Suvadeep Bose154960129071
Ashok Kumar1515654164086
Philip S. Yu1481914107374
Hugh A. Sampson14781676492
Aaron Dominguez1471968113224
Gregory R Snow1471704115677
J. S. Keller14498198249
C. Ronald Kahn14452579809
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202388
2022363
20212,772
20202,695
20192,527
20182,500