University at Buffalo

About: University at Buffalo is a education organization based out in Buffalo, New York, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 33773 authors who have published 63840 publications receiving 2278954 citations. The organization is also known as: UB & State University of New York at Buffalo.

A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Abstract: We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

Schooling and environmental education: Contradictions in purpose and practice

Abstract: A number of authors have observed a pronounced discrepancy between the problem‐solving and action‐oriented goals associated with the contemporary philosophy of environmental education and an emphas...

Perspective taking and prejudice reduction: the mediational role of empathy arousal and situational attributions

Abstract: This research was designed to examine whether perspective taking promotes improved intergroup attitudes regardless of the extent that stereotypic perceptions of outgroups are endorsed, as well as examining the mechanisms (attributional or empathy related) by which perspective taking motivates improved intergroup attitudes. Participants were presented with an interview segment where an African American interviewee discussed the difficulties experienced as a result of his membership in a negatively stereotyped group. Materials were presented in a 2 (perspective taking: other focused or objective focused) × 2 (target stereotypicality: confirming or disconfirming) between participants design. Findings revealed that the manipulation of target stereotypicality influenced subsequent stereotype endorsement; those exposed to a stereotype confirming target later endorsed more stereotypic perceptions of African Americans than did those exposed to a stereotype disconfirming target. However, perspective taking promoted improved intergroup attitudes irrespective of stereotypicality; those encouraged to adopt the perspective of the target later reported more favourable intergroup attitudes than did those who remained detached and objective listeners. Whereas empathy partially mediated the relation between perspective taking and intergroup attitudes, situational attributions were a stronger and more reliable mediator. Copyright © 2003 John Wiley & Sons, Ltd.

Alcohol-related morbidity and mortality.

Abstract: Alcohol use is related to a wide variety of negative health outcomes including morbidity, mortality, and disability. Research on alcohol-related morbidity and mortality takes into account the varying effects of overall alcohol consumption and drinking patterns. The results from this epidemiological research indicate that alcohol use increases the risk for many chronic health consequences (e.g., diseases) and acute consequences (e.g., traffic crashes), but a certain pattern of regular light-to-moderate drinking may have beneficial effects on coronary heart disease. Several issues are relevant to the methodology of studies of alcohol-related morbidity and mortality, including the measurement of both alcohol consumption and the outcomes studied as well as study design. Broad summary measures that reflect alcohol's possible effects on morbidity, mortality, and disability may be more useful than measures of any one outcome alone.

Ultrafast Computed Tomography as a Diagnostic Modality in the Detection of Coronary Artery Disease A Multicenter Study

Abstract: Background Ultrafast computed tomography (CT), by acquiring images of the proximal coronary arteries, detects coronary calcifications and has been demonstrated to be highly sensitive for the detection of coronary artery disease in many small studies. The aim of this study was to determine the relationship between ultrafast CT scanning and coronary angiography in a large number of symptomatic patients. Methods and Results The study population consisted of 710 patients from six participating centers. A multivariate logistic regression model was used to evaluate the individual contributions of age, number of calcified vessels, and the calcium score for the probability of angiographically significant disease. Of the 710 patients enrolled, 427 patients had significant angiographic disease, and coronary calcification was detected in 404, yielding a sensitivity of 95%. Of the 23 patients without calcifications, 19 (83%) had single-vessel disease at angiography. Of the 283 patients without angiographically signif...