Institution
University College Cork
Education•Cork, Ireland•
About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Context (language use). The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.
Topics: Population, Context (language use), Irish, Gut flora, Health care
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this article, the phase space approach to general relativity in the asymptotically flat context is reconsidered, phrasing it in the language of symplectic geometry, and the necessary boundary conditions at spatial infinity are spelled out in detail.
230 citations
••
229 citations
••
TL;DR: In this article, the authors performed whole-virome analysis on a published keystone inflammatory bowel disease (IBD) cohort and an in-house ulcerative colitis dataset to shed light on the composition of the human gut virome in IBD beyond this identifiable minority.
229 citations
••
TL;DR: It is reported that native cytosolic Rabaptin‐5 is present in a homodimeric state and dimerization depends upon the presence of its coiled‐coil predicted sequences, and it is proposed that Rabapt in‐between two sequentially acting GTPases to coordinate endocytic and recycling traffic.
Abstract: Rabaptin-5 functions as an effector for the small GTPase Rab5, a regulator of endocytosis and early endosome fusion. We have searched for structural determinants that confer functional specificity on Rabaptin-5. Here we report that native cytosolic Rabaptin-5 is present in a homodimeric state and dimerization depends upon the presence of its coiledcoil predicted sequences. A 73 residue C-terminal region of Rabaptin-5 is necessary and sufficient both for the interaction with Rab5 and for Rab5-dependent recruitment of the protein on early endosomes. Surprisingly, we uncovered the presence of an additional Rabbinding domain at the N-terminus of Rabaptin-5. This domain mediates the direct interaction with the GTPbound form of Rab4, a small GTPase that has been implicated in recycling from early endosomes to the cell surface. Based on these results, we propose that Rabaptin-5 functions as a molecular linker between two sequentially acting GTPases to coordinate endocytic and recycling traffic.
228 citations
••
TL;DR: In this article, the effect of transglutaminase on breads was evaluated by fundamental rheological tests, texture profile analysis, and standard baking tests, and the results showed that TGase can be successfully applied to gluten-free flours to improve their breadmaking potentials by promoting network formation.
228 citations
Authors
Showing all 12300 results
Name | H-index | Papers | Citations |
---|---|---|---|
Stephen J. O'Brien | 153 | 1062 | 93025 |
James J. Collins | 151 | 669 | 89476 |
J. Wouter Jukema | 124 | 785 | 61555 |
John F. Cryan | 124 | 723 | 58938 |
Fergus Shanahan | 117 | 705 | 51963 |
Timothy G. Dinan | 116 | 689 | 60561 |
John M. Starr | 116 | 695 | 48761 |
Gordon G. Wallace | 114 | 1267 | 69095 |
Colin Hill | 112 | 693 | 54484 |
Robert Clarke | 111 | 512 | 90049 |
Douglas B. Kell | 111 | 634 | 50335 |
Thomas Bein | 109 | 677 | 42800 |
Steven C. Hayes | 106 | 450 | 51556 |
Åke Borg | 105 | 444 | 53835 |
Eamonn Martin Quigley | 103 | 685 | 39585 |