University College Cork

About: University College Cork is a education organization based out in Cork, Ireland. It is known for research contribution in the topics: Population & Irish. The organization has 12056 authors who have published 28452 publications receiving 958414 citations. The organization is also known as: Coláiste na hOllscoile Corcaigh & National University of Ireland, Cork.

Early Pregnancy Prediction of Preeclampsia in Nulliparous Women, Combining Clinical Risk and Biomarkers The Screening for Pregnancy Endpoints (SCOPE) International Cohort Study

Abstract: More than half of all cases of preeclampsia occur in healthy first-time pregnant women. Our aim was to develop a method to predict those at risk by combining clinical factors and measurements of biomarkers in women recruited to the Screening for Pregnancy Endpoints (SCOPE) study of low-risk nulliparous women. Forty-seven biomarkers identified on the basis of (1) association with preeclampsia, (2) a biological role in placentation, or (3) a role in cellular mechanisms involved in the pathogenesis of preeclampsia were measured in plasma sampled at 14 to 16 weeks' gestation from 5623 women. The cohort was randomly divided into training (n=3747) and validation (n=1876) cohorts. Preeclampsia developed in 278 (4.9%) women, of whom 28 (0.5%) developed early-onset preeclampsia. The final model for the prediction of preeclampsia included placental growth factor, mean arterial pressure, and body mass index at 14 to 16 weeks' gestation, the consumption of ≥3 pieces of fruit per day, and mean uterine artery resistance index. The area under the receiver operator curve (95% confidence interval) for this model in training and validation cohorts was 0.73 (0.70-0.77) and 0.68 (0.63-0.74), respectively. A predictive model of early-onset preeclampsia included angiogenin/placental growth factor as a ratio, mean arterial pressure, any pregnancy loss <10 weeks, and mean uterine artery resistance index (area under the receiver operator curve [95% confidence interval] in training and validation cohorts, 0.89 [0.78-1.0] and 0.78 [0.58-0.99], respectively). Neither model included pregnancy-associated plasma protein A, previously reported to predict preeclampsia in populations of mixed parity and risk. In nulliparous women, combining multiple biomarkers and clinical data provided modest prediction of preeclampsia.

Halogen activation via interactions with environmental ice and snow in the polar lower troposphere and other regions

Abstract: The role of ice in the formation of chemically active halogens in the environment requires a full understanding because of its role in atmospheric chemistry, including controlling the regional atmospheric oxidizing capacity in specific situations. In particular, ice and snow are important for facilitating multiphase oxidative chemistry and as media upon which marine algae live. This paper reviews the nature of environmental ice substrates that participate in halogen chemistry, describes the reactions that occur on such substrates, presents the field evidence for ice-mediated halogen activation, summarizes our best understanding of ice-halogen activation mechanisms, and describes the current state of modeling these processes at different scales. Given the rapid pace of developments in the field, this paper largely addresses advances made in the past five years, with emphasis given to the polar boundary layer. The integrative nature of this field is highlighted in the presentation of work from the molecular to the regional scale, with a focus on understanding fundamental processes. This is essential for developing realistic parameterizations and descriptions of these processes for inclusion in larger scale models that are used to determine their regional and global impacts.

Magnetic field strength and spectral distribution of six parsec-scale active galactic nuclei jets

Abstract: We use observations of six 'blazars' with the Very Long Baseline Array (VLBA), at eight frequencies (4.6, 5.1, 7.9, 8.9, 12.9, 15.4, 22.2 and 43.1 GHz), to investigate the frequency-dependent position of their VLBI cores ('core-shift') and their overall jet spectral distribution. By cross-correlating the optically thin jet emission, we are able to accurately align the multifrequency images of three of the jets (1418+546, 2007+777, 2200+420), whose core-shifts and spectra we find consistent with the equipartition regime of the Blandford & Konigl conical jet model, where the position of the radio core from the base of the jet follows r core (ν) ∝ ν ―1 For the jet of 0954+658, we align the higher frequency images using our lower frequency measurements assuming equipartition in the radio core from 4.6―43 GHz. The jet emission of the other two sources in our sample (1156+295, 1749+096) is too sparse for our alignment technique to work. Using our measured core-shifts, we calculate equipartition magnetic field strengths of the order of 10s to 100s of mG in the radio cores of these four AGN from 4.6―13 GHz. Extrapolating our results back to the accretion disc and black hole jet-launching distances, we find magnetic field strengths consistent with those expected from theoretical models of magnetically powered jets.